Re: The Risk of Oral Contraceptives in the Etiology of Inflammatory Bowel Disease: A Meta-Analysis

[Guest guest]

do you do anything else to control flares? i am 34 and i am

experiencing terrible pain due to an inflamed colon. they have me on

cipro and i take colazal...but i have been in pain for a month. any

suggestions? thanks so much rachel.

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> I developed UC when I was 7 (now 58!). When I got married (1972) and

used OC I had a huge and horrific flare. At that time the link wasn't

known, but was suspected. Stopping OC cleared my flare!

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> DutchPat

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http://www.ingentaconnect.com/content/bsc/ajg/2008/00000103/00000009/art\

00036;jsessionid=5va6477jd3je.alexandra

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> The Risk of Oral Contraceptives in the Etiology of Inflammatory Bowel

Disease: A Meta-Analysis

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> Authors: Cornish, J.A.1; Tan, E.1; Simillis, C.1; , S.K.2; Teare,

J.3; Tekkis, Paris P.1

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> Source: The American Journal of Gastroenterology, Volume 103, Number

9, September 2008 , pp. 2394-2400(7)

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> Publisher: Blackwell Publishing

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> Abstract:

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> OBJECTIVES: Several environmental and genetic factors have been

implicated to date in the development of Crohn's disease (CD) and

ulcerative colitis (UC). The aim of this study was to provide a

quantification of the risk of oral contraceptive pill (OCP) use in the

etiology of inflammatory bowel disease.

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> METHODS: A literature search was performed to identify comparative

studies reporting on the association of oral contraceptive use in the

etiology of UC and CD between 1983 and 2007. A random-effect

meta-analysis was used to compare the incidence of UC or CD between the

patients exposed to the OCP and nonexposed patients. The results were

adjusted for smoking.

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> RESULTS: A total of 75,815 patients were reported on by 14 studies,

with 36,797 exposed to OCP and 39,018 nonexposed women. The pooled

relative risk (RR) for CD for women currently taking the OCP was 1.51

(95% confidence interval [CI] 1.17-1.96, P= 0.002), and 1.46 (95% CI

1.26-1.70, P < 0.001), adjusted for smoking. The RR for UC in women

currently taking the OCP was 1.53 (95% CI 1.21-1.94, P= 0.001), and 1.28

(95% CI 1.06-1.54, P= 0.011), adjusted for smoking. The RR for CD

increased with the length of exposure to OCP. Moreover, although the RR

did not reduce once the OCP was stopped, it was no longer significant

once the OCP was stopped (CI contains 1), both for CD and for UC.

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> CONCLUSIONS: This study provides evidence of an association between

the use of oral contraceptive agents and development of IBD, in

particular CD. The study also suggests that the risk for patients who

stop using the OCP reverts to that of the nonexposed population.

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> (Am J Gastroenterol 2008;103:2394-2400)

> Document Type: Research article

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> DOI: 10.1111/j.1572-0241.2008.02064.x

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> Affiliations: 1: Department of Biosurgery and Surgical Technology 2:

Department of Surgery, St. Mark's Hospital, London, United Kingdom 3:

Gastroenterology Unit, St. 's Hospital, Imperial College

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