Doxepin info

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Another drug they make up for topical vulvar use is a tri cyclic antidepressant called doxepin...and they can mix it with a milder steroid like Triamcinolone for pain relief. (esp. for those who might use an antihistamine since it helps lower that histamine level) Some brand names for this cream/ointment are ZONALON OR PRUDOXIN. (both are prescriptions). I

have a study that states this..... "Doxepin cream has been found to control the pruritus (itchiness) inflammation and pain of atopic dermatitis, eczema, and urticaria - with results ''superior'' to the use of any steroid cream or oral antihistamines." (In fact 10 X's better said one study. Dee t) "Topical Doxepin provided as a five-percent cream has been shown to be extremely effective in controlling the itch, burning pain and inflammation caused by a number of types of dermatitis" And this below is another abstract about it. From the Journal of American Academy of Dermatology. Volume 41, Issue 2, Pages 209-214 (August 1999) Pharmacokinetics of doxepin in

subjects with pruritic atopic dermatitis AbstractBackground: Doxepin applied topically by itself or in combination with triamcinolone acetonide is a safe and effective treatment for atopic dermatitis. Objective: We evaluated the pharmacokinetic profile of doxepin and desmethyldoxepin after topical application of doxepin hydrochloride 5% cream alone or in combination with

0.025% triamcinolone acetonide (doxepin/TAC). Methods: Twenty-four subjects with atopic dermatitis received either doxepin or doxepin/TAC cream 4 times daily for 7 days in a randomized, double-blind, controlled trial. Serum samples were obtained and pharmacokinetic parameters estimated from the dose-normalized serum concentrations of doxepin and desmethyldoxepin. Efficacy and adverse experiences were determined by physician and subject evaluations. Results:

Pharmacokinetic parameters (Ke , t1/2 and AUC) calculated in 9 subjects (doxepin/TAC = 4 subjects, DOXEPIN = 5 subjects) with detectable serum concentrations were similar for both groups. Pruritus relief and lessening of pruritus severity were significantly greater with doxepin/TAC than doxepin alone. Conclusion: Topically applied doxepin is safe and effective therapy for pruritus. (severe itching, dt) (J Am Acad Dermatol 1999;41:209-14.) © 1999 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.