The INSPIRE study: Are different personality traits related to disease-specific quality of life (IBDQ) in distressed patients with ulcerative colitis and Crohn's disease?

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http://www3.interscience.wiley.com/cgi-bin/abstract/117892662/ABSTRACT?CRETRY=1 & SRETRY=0

Original Article

The INSPIRE study: Are different personality traits related to disease-specific quality of life (IBDQ) in distressed patients with ulcerative colitis and Crohn's disease?

Birgitte Boye, MD, PhD 1 2 *, n Jahnsen , MD, PhD 3, Kjell Mokleby, PhD 2, Siv Leganger, PhD 2, Günter Jantschek, MD, PhD 4, Ingrid Jantschek, MD 4, Sebastian Kunzendorf, MD 4, Dieter Benninghoven, PhD 4, Ingvard Wilhelmsen, MD, PhD 5 6, Sharpe, MD 7, Svein Blomhoff, MD, PhD 2, Ulrik F. Malt, MD, PhD 1 2, Knut E A. Lundin, MD, PhD 8 9

1Institute of Psychiatry, University of Oslo, Norway2Department of Neuropsychiatry and Psychosomatic Medicine, Division of Clinical Neurosciences, Rikshospitalet University Hospital, Oslo; Norway3Department of Gastroenterology, Aker University Hospital, Oslo, Norway4Department of Psychosomatic and Psychotherapy, University-Clinic Schleswig-Holstein, Campus Lübeck, Germany5Institute of Internal Medicine, University of Bergen, Norway6Haraldsplass Deaconal Hospital, Bergen, Norway7School of Molecular and Clinical Medicine, University of Edinburgh, United Kingdom8Department of Internal Medicine, Gastroenterology section, Division of Medicine, Rikshospitalet University Hospital, Oslo; Norway9Rikshospitalet Faculty Group, University of Oslo, Norway

email: Birgitte Boye (birgitte.boye@...)

*Correspondence to Birgitte Boye, Department of Neuropsychiatry and Psychosomatic Medicine, Rikshospitalet University Hospital, N-0027 Oslo, Norway

Funded by: Norwegian Research Council; Grant Number: Project number160044/v50 Helse-Soer; Grant Number: Project number 3b-111

Keywords

inflammatory bowel disease • Crohn's disease • personality • quality of life • ulcerative colitis

Abstract

Background: To explore the relationship between personality and disease-specific quality of life [inflammatory Bowel Disease Questionnaire (IBDQ)] in distressed [Perceived Stress Questionnaire (PSQ)] patients with ulcerative colitis (UC) and Crohn's disease (CD).

Methods: Included in the study were 56 patients with UC and 54 patients with CD ranging in age from 18 to 60 years with a relapse in the previous 18 months, a UC or CD activity index 4, a PSQ 60, and without serious mental or other serious medical condition. The patients completed the Buss- Aggression Questionnaire, the Neuroticism and Lie (social conformity/desirability) scales of the Eysenck Personality Questionnaire, the Multidimensional Health Locus of Control (LOC) Scale [internal (I), Powerful Other (PO), Chance ©], the Toronto ithymia Scale, and the IBDQ.

Results: In linear regression controlling for sex, education (years), and clinical disease activity (AI) in separate analyses of UC and CD patients, higher IBDQ score was related to less social conformity in CD and less neuroticism in UC; higher emotional function score was related to less neuroticism in both CD and UC and less PO-LOC in UC. Higher social function score was related to less social conformity in CD and lower I-LOC and PO-LOC in UC. Bowel function and systemic symptoms were unrelated to personality in either UC or CD.

Conclusions: Although the emotional function subscale was related to neuroticism in both UC and CD, the social function subscale and total IBDQ were related to different personality traits in UC and CD. Personality traits should be taken into account when using IBDQ in studies.

(Inflamm Bowel Dis Volume 14, Issue 5 , Pages 680 - 686, 2007)

Received: 12 September 2007; Accepted: 13 November 2007

Digital Object Identifier (DOI)10.1002/ibd.20367