Ulcerative colitis susceptibility genes identified

[Guest guest]

For those interested in the genetics of inflammatory bowel disease,

here are 3 articles of interest that appeared in PubMed today:

e A, Balschun T, Karlsen TH, Hedderich J, May S, Lu T, Schuldt

D, Nikolaus S, Rosenstiel P, Krawczak M, Schreiber S (2008)

Replication of signals from recent studies of Crohn's disease

identifies previously unknown disease loci for ulcerative colitis.

Nat. Genet. Apr 27 [Epub ahead of print].

http://www.ncbi.nlm.nih.gov/pubmed/18438405

Fisher SA, Tremelling M, CA, Gwilliam R, Bumpstead S,

Prescott NJ, Nimmo ER, Massey D, Berzuini C, C, Barrett JC,

Cummings FR, Drummond H, Lees CW, Onnie CM, Hanson CE, Blaszczyk K,

Inouye M, Ewels P, Ravindrarajah R, Keniry A, Hunt S, M,

Watkins N, Ouwehand W, CM, Cardon L; the Wellcome Trust Case

Control Consortium, Lobo A, Forbes A, on J, Jewell DP,

Mansfield JC, Deloukas P, Mathew CG, Parkes M, Satsangi J (2008)

Genetic determinants of ulcerative colitis include the ECM1 locus and

five loci implicated in Crohn's disease. Nat. Genet. Apr 27 [Epub

ahead of print].

http://www.ncbi.nlm.nih.gov/pubmed/18438406

Zhernakova A, Festen EM, e L, Trynka G, van Diemen CC, Monsuur

AJ, Bevova M, Nijmeijer RM, van 't Slot R, Heijmans R, Boezen HM, van

Heel DA, van Bodegraven AA, Stokkers PC, Wijmenga C, Crusius JB,

Weersma RK (2008) Genetic analysis of innate immunity in Crohn's

disease and ulcerative colitis identifies two susceptibility loci

harboring CARD9 and IL18RAP. Am. J. Hum. Genet. Apr 23 [Epub ahead of

print].

http://www.ncbi.nlm.nih.gov/pubmed/18439550

Most previous studies of IBD genetics have tended to focus more on

Crohn's disease than on ulcerative colitis, and so it's now

encouraging to see that UC is receiving some needed attention.

Whether these will be relevant to the ulcerative colitis commonly

found with PSC remains to be seen.

Dave R.

(father of (22); PSC 07/03; UC 08/03)