Re: Pharmacokinetics of DMSA

[Guest guest]

TK--- you will have to give me some resource pages where you pulled

the information if you wish an accurate response to make sure what

you are really compairing too. I think you are misreading the

inforamtion.

>

> TK or anyone else!

>

> After almost 2 years detoxing mostly with ALA I recently found that

a

> tooth with a gold crown had amalgam under it. This maybe explains

why

> I have seen little improvement. The amalgam filling has now been

> removed and replaced with a ceramic one. To reduce any extra Hg

> burden in my body before going back to ALA I am starting with DMSA

> again for a while.

>

> My query regards the calculation regarding the pharmacokinetics of

> DMSA based on Andy Cutler's book. In it he gives the equation for

the

> rate of mercury reduction as a factor of the normal unchelated

rate,

> i.e. Fu = 1 + (d/24)^0.409 for DMSA.

>

> My consternation was finding that for the trouble of taking 25 mg

of

> DMSA 8 times per day and 30 times per week the removal rate of Hg

> above the normal unchelated rate at my weight (85 kg) is only about

> 6%. This means that taking DMSA only speeds up Hg removal by 6% or

> put another way instead of chelating for one year I could do

nothing

> for a period of 55 weeks and get the same result.

>

> With ALA the calculation is only slightly better because the faeces

> rate is 2.5 times higher than the urine rate. Naturally, ALA also

has

> the undeniable important advantage of also removing Hg across the

> blood barrier.

>

> Have you or anyone else here checked out this calculation?

> Regards

>

>

[Guest guest]

>

> TK or anyone else!

> My query regards the calculation regarding the pharmacokinetics of

> DMSA based on Andy Cutler's book. In it he gives the equation for

the

> rate of mercury reduction as a factor of the normal unchelated

rate,

> i.e. Fu = 1 + (d/24)^0.409 for DMSA.

TK--This formula is based on a single daily dose and not on multiple

doses. So if I am understanding it correctly your excretion would be

multiplied. I am not great with formulas so you may want to clarify

this with Andy to make sure.

>

> My consternation was finding that for the trouble of taking 25 mg

of

> DMSA 8 times per day and 30 times per week the removal rate of Hg

> above the normal unchelated rate at my weight (85 kg) is only about

> 6%. This means that taking DMSA only speeds up Hg removal by 6% or

> put another way instead of chelating for one year I could do

nothing

> for a period of 55 weeks and get the same result.

TK--- Maybe if your body is healthy and working correctly and

excreting Hg properly. Andy has probably gone over these formulas

before in the archives on omnibasu, you may want to search there.

>

> With ALA the calculation is only slightly better because the faeces

> rate is 2.5 times higher than the urine rate. Naturally, ALA also

has

> the undeniable important advantage of also removing Hg across the

> blood barrier.

>

> Have you or anyone else here checked out this calculation?

TK--- only to a limited extent. I know I am very Hg toxic so I do

not really have a choice in the matter of chelation unless I want to

stay sick and get worse. I also know dmsa and dmps increase

excretion by a % and for those of us that are Hg toxic and not

excreting Hg on own they are pretty much a necessity. They also

help increse excretion further when using them in conjunction with

ALA and help decrease the side effects of ALA for many people. ALA

is the only chelator that will chelate Hg from the brain and organs.

These are all very important for many people, not for all. This will

be something you will need to decide with the information you have.

> Regards

>

>