Fwd: BioMed Today Announcement - March 2012

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Winter Issue 2012

Announcement from Dr. Shaw

The biochemical basis of autism: Strong evidence that increased acetaminophen use in genetically vulnerable children appears to be the major cause of the autism epidemic.

By Shaw, Ph.D.

It appears that the marked increase in the rate of autism throughout much of the world may be largely mediated by the marked increase in the use of acetaminophen in genetically and/or metabolically susceptible children and perhaps the use of acetaminophen by pregnant women.

The evidence for this hypothesis is already in the peer-reviewed medical literature. Toxicity of acetaminophen appears to cause autism by multiple means including defective sulfation pathways to eliminate acetaminophen that leads to marked increases in the metabolites of a number of species of intestinal Clostridia bacteria prevalent in autism. The increase in Clostridia metabolites significantly decrease brain dopamine beta hydroxylase activity causing an overproduction of brain dopamine and reduced concentrations of brain nor epinephrine. This leads to obsessive, compulsive, stereotypical behaviors associated with brain dopamine excess, reduced exploratory behavior, and learning in novel environments that are associated with norepinephrine deficiency. Such increases in dopamine have been verified by finding marked increases in the major dopamine metabolite homovanillic acid (HVA) in urine. The increased concentrations of dopamine are directly related to the degree of abnormal behavior.

With sulfation of acetaminophen diminished in autism, a larger than usual amount of acetaminophen is detoxified by the cytochrome p450 2E1 system that leads to excessive production of N-acetyl-p-benzoquinone imine (NAPQI) a very toxic metabolite that depletes glutathione, reducing the ability to detoxify a host of toxic chemicals in the environment. The increase of NAPQI creates oxidative stress leading to protein, lipid, and nucleic acid damage from free radicals, causing an increased rate of mitochondrial damage and damage to mitochondrial and nuclear DNA. Impairment of mitochondrial is prevalent in autism. NAPQI production has been found to be increased in humans at recommended dosages of acetaminophen and would be expected to be even higher in people with diminished sulfation capacity.

Featured Article

Recent Study Reveals the Effects of Supplements on Children and Adults with Autism

Supplements are among the most commonly used treatments for autism, but the research on their use for treating autism has been limited, until recently.

A research article published by BMC Pediatrics has outlined a study involving children and adults with autism and the effect vitamin and mineral supplements had on their symptoms.

The study was a randomized, double-blind, placebo-controlled three month vitamin/mineral treatment study involving 141 children and adults with autism. None of the participants had taken a vitamin/mineral supplement in the two months prior to the start of the study. For a subset of the participants (53 children ages 5-16) pre and post measurements of nutritional and metabolic status were also conducted.

The vitamin/mineral supplement was generally well-tolerated and individually titrated to optimum benefit. Levels of many vitamins, minerals, and biomarkers improved/increased showing good compliance and absorption. Statistically significant improvements in metabolic status were many including: total sulfate, S-adenosylmethionine, reduced glutathione, ratio of oxidized glutathione to reduced glutathione, nitrotyrosine, ATP, NADH, and NADPH. Most of these metabolic biomarkers improved to normal or near-normal levels.

Syndion (mentioned in the article to the right) was a supplement used in the study. Visit New Beginnings Nutritionals to learn more.

Read the abstract here.

BMC Pediatrics 2011, 11:111 doi:10.1186/1471-2431-11-111

Published: 12 December 2011

Related Article

The Question of Fever in Children – What To Do, Options For Treatment

By Kurt N. Woeller, D.O.

Fever in a child is a common concern for parents. It is important to understand that a fever is a natural result of your child’s body responding to an infection or inflammation. In the vast majority of cases a fever will resolve on its own and not lead to serious complications. A body temperature of 100.5 degrees Fahrenheit or higher is considered a fever. In most cases, a fever is generated by the immune system responding to a virus or bacteria. Less common causes of fever can be toxic exposure (to a chemical/drug), inflammatory bowel disease or autoimmune disorders, and cancer. For most children with fever their body temperature is not going to continue to rise to the point of being dangerous, such as triggering a seizure or causing brain damage, at least for temperatures less than 107 degree Fahrenheit. Higher fevers (105 degrees Fahrenheit) can indicate the likelihood of a more serious bacterial infection versus a viral infection. Prolonged fevers (last more than four to five days) may warrant further investigation. As always, if you are unsure about your child’s condition consult with your personal physician.

One situation where fever is absolutely critical to have evaluated immediately is a rectal temperature of 100.5 degrees Fahrenheit or higher in a newborn less than eight weeks. Newborns do not have a mature immune system so they are more susceptible to serious infection. Any fever in a newborn needs to be evaluated immediately by a pediatrician or emergency room staff. Often parents will reach for a medication to reduce fever at the first sign of elevated temperature. In the vast majority of cases this is unnecessary. Remember, if your child is sick the fever is actually helping to fight the infection. Ibuprofen and acetaminophen are the two most common over-the-counter (OTC) medications taken for fever. Recent evidence about the deleterious effects of acetaminophen makes this medication much less desirable. Therefore, Ibuprofen is still a viable option for most kids. Personally, I try to avoid reducing a fever with medication if a child is ill, but is still playful, sleeping okay, and has good appetite. In most cases, I will only treat a fever with Ibuprofen if a child is miserable with body aches, sleeping poorly, and not eating. Studies have shown that fever can resolve sooner if left untreated with medication.

Homeopathy is a natural medicine option that may be helpful in reducing fevers particularly, from homeopathic preparations. Here are a few common homeopathic remedies used for fever:

Aconite - used for acute onset high fever. There is no sweat. Child is apprehensive and anxious. Fever may come on after a period of cold weather.Belladonna - used for acute onset high fever. Child is usually sweating and may be fearful. Pupils are dilated.Ferrum phosphoricum - a less acute onset and/or not so high degree of fever. Child isn't as sick appearing.

These remedies are usually available OTC in potencies of 12C or 30C - either of which could be given every two to three hours until the fever breaks. Generally, a remedy should be showing positive effects by the third dose.

Read the entire article here.

Dr. Kurt Woeller is Medical Director of Sunrise Complementary Medical Center and www.AutismActionPlan.com (an online subscription website for patient-physician access regarding biomedical intervention). You can learn more about Dr. Woeller and his biomedical related services at www.DrWoeller.com.

Markers Added to The Great Plains Laboratory Organic Acids Test

The new and improved Organic Acids Test has increased the number of tested compounds to 74 and two new markers have been added. Descriptions of the new markers are listed below:

4-Cresol – Marker for Bacteria Including Selected ClostridiaIndicates a possible overgrowth of intestinal bacteria that are specific p-cresol producers including selected Clostridia. 4-Cresol is a phenolic product poorly metabolized in children with autism. High-potency multi-strain probiotics may help rebalance gastrointestinal flora.Tricarballylic Acid – Marker for Exposure to Certain Fungal Contamination in FoodsA chemical by-product released from fumonisins during passage through the gastrointestinal tract. Fumonisins are fungal toxins produced primarily by F. verticillioides. Elevated levels can be caused by the intake of corn or corn-based food contaminated with fumonisins.

New Syndion Powder Available at

New Beginnings Nutritionals

Syndion Powder is now available at New Beginnings Nutritionals by phone orders only. The powder is easier to dose for those mixing into beverages, costs 15 percent less per dose, and contains the same updated formulation as the capsules.

Use coupon code Powder1 to receive a 25 percent discount on Syndion Powder through the end of March on New Beginnings website.

Syndionâ„¢ is an antioxidant, multivitamin and mineral supplement formulation developed by Dr. Jim , autism researcher at the University of Arizona based on clinical research data.

This supplement is designed for individuals with developmental, gastrointestinal, or behavioral issues that limit broad food choices or who have special nutritional needs or food sensitivities. Syndionâ„¢ products contain a microsphere technology that facilitates absorption of fat-soluble nutrients even when even when there is pancreatic impairment, liver dysfunction or digestive issues.

Featured Webinar

“Brain Regions and their Dysfunction in Autism – Clinical Correlation for Behavior, Language, and Cognitive Problemsâ€

Presented by Dr. Kurt Woeller on March 7, 2012

There are core issues involved in autism such as behavior, speech, and socialization. Understanding more about the brain and the regions involved can provide insight into what a particularly person’s problems may be.

Dr. Woeller will discuss the basics of brain anatomy and the clinical correlation in autism and the brain areas most commonly affected.

Register for this webinar.

Recorded Webinars

Watch free, recorded webinars and instructional videos covering a wide range of health topics.

Watch now.

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