Re: Mouse model of sclerosing cholangitis/Cholesterol question

[Guest guest]

Hi Sandy;

High cholesterol, together with fat-soluble vitamin deficiencies, is

something to keep an eye on as PSC progresses.

nsen RA, Lindor KD, Sartin JS, LaRusso NF, Wiesner RH 1995 Serum

lipid and fat-soluble vitamin levels in primary sclerosing

cholangitis. J. Clin. Gastroenterol. 20: 215-219.

http://www.ncbi.nlm.nih.gov/pubmed/7797830

I would think that if a patient had high cholesterol, then limiting

intake of cholesterol would be a good idea.

Interestingly, ursodiol has been shown to lower serum cholesterol in

PBC patients:

Balan V, Dickson ER, nsen RA, Lindor KD 1994 Effect of

ursodeoxycholic acid on serum lipids of patients with primary biliary

cirrhosis. Mayo Clin. Proc. 69: 923-929.

http://www.ncbi.nlm.nih.gov/pubmed/7934188

Cholesterol lowering agents such as statins and fibrates are also

options to consider in consultation with your doctor:

http://www.psc-literature.org/fibrate.htm

Best regards,

Dave

(father of (23); PSC 07/03; UC 08/03)

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> Dave, Does this suggest that it might be important to monitor

> cholesterol? I'm wondering if it would make sense for my son to

> limit the eggs that he eats?

> Sandy

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