Intestinal alkaline phosphatase

[Guest guest]

Lipopolysaccharide is a very toxic product produced by gut bacteria.

Intestinal alkaline phosphatase plays an important role in

detoxifying lipopolysaccharide in the intestines. It's been the

subject of a number of recent papers:

Bates JM, Akerlund J, Mittge E, Guillemin K. Intestinal alkaline

phosphatase detoxifies lipopolysaccharide and prevents inflammation

in zebrafish in response to the gut microbiota. Cell Host Microbe.

2007 Dec 13;2(6):371-82.

http://www.ncbi.nlm.nih.gov/pubmed/18078689

Vaishnava S, Hooper LV. Alkaline phosphatase: keeping the peace at

the gut epithelial surface. Cell Host Microbe. 2007 Dec 13;2(6):365-7.

http://www.ncbi.nlm.nih.gov/pubmed/18078687

Strauss E. Microbiology. Detoxifying enzyme helps animals stomach

bacteria. Science. 2007 Dec 21;318(5858):1853-4.

http://www.ncbi.nlm.nih.gov/pubmed/18096780

Goldberg RF, Austen WG Jr, Zhang X, Munene G, Mostafa G, Biswas S,

McCormack M, Eberlin KR, Nguyen JT, Tatlidede HS, Warren HS, Narisawa

S, Millán JL, Hodin RA. Intestinal alkaline phosphatase is a gut

mucosal defense factor maintained by enteral nutrition. Proc Natl

Acad Sci U S A. 2008 Mar 4;105(9):3551-6.

http://www.ncbi.nlm.nih.gov/pubmed/18292227

Geddes K, Philpott DJ. A new role for intestinal alkaline phosphatase

in gut barrier maintenance. Gastroenterology. 2008 Jul;135(1):8-12.

http://www.ncbi.nlm.nih.gov/pubmed/18549817

It has now been shown that intestinal alkaline phosphatase (iAP) is

markedly down-regulated in inflammed tissue of Crohn's and ulcerative

colitis patients, and that feeding iAP-tablets to colitic rats

resulted in a significant attenuation of colonic inflammation:

Tuin A, Poelstra K, Jager-Krikken AD, Bok L, Raaben W, Velders MP,

Dijkstra G. Role of alkaline phosphatase in colitis in man and rats.

Gut. 2008 Oct 13. [Epub ahead of print].

http://www.ncbi.nlm.nih.gov/pubmed/18852260

The authors suggest that iAP-tablets be considered as a novel

treatment approach for IBD.

Best regards,

Dave

(father of (23); PSC 07/03; UC 08/03)