Vitamin D status in gastrointestinal and liver disease

[Guest guest]

http://www.co-gastroenterology.com/pt/re/cogastro/abstract.00001574-200803000-00013.htm;jsessionid=HgLfz1dLBgdHzrLn0d2n4wsncJNLMhnj2TmpQPssjn3gqGBJSGRg!592949099!181195629!8091!-1

..

Nutrition Current Opinion in Gastroenterology. 24(2):176-183, March 2008.Pappa, Helen M a,b; Bern, Elana a,b; Kamin, a,b; Grand, J a,b

Abstract: Purpose of review: The purpose of this review is to report on the vitamin D status and its relationship with bone health in individuals with gastrointestinal and liver disorders. In addition, recommendations regarding replacement and maintenance of optimal vitamin D stores, as well as the state of knowledge regarding its effect on the disease through its actions on the immune system, will be reviewed. Recent findings: The scientific community has revised upward the serum levels of vitamin D considered optimal, and doses of vitamin D much larger than those currently recommended may be needed to maintain these levels, especially in individuals with gastrointestinal and liver disorders. The relationship between vitamin D and bone health in this population is controversial. The role of vitamin D in the regulation of the immune system continues to be elucidated. Summary: Hypovitaminosis D is prevalent among individuals with gastrointestinal and liver disease. Although replacement and supplementation guidelines have not been well defined, practitioners should aim for a serum 25-hydroxyvitamin D level of at least 32 ng/ml. The contribution of vitamin D to the bone health of these individuals and its role in altering disease course through its actions on the immune system remain to be elucidated. © 2008 Lippincott & Wilkins, Inc.