SchaferAutismReport: Fever During Pregnancy More Than Doubles the Risk of Autism or Developmental Delay

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RESEARCH

Fever During Pregnancy More Than Doubles the Risk of Autism or

Developmental Delay

A team of UC researchers has found that mothers who

had fevers during their pregnancies were more than twice as likely to

have a child with autism or developmental delay than were mothers of

typically developing children, and that taking medication to treat

fever countered its effect.

ScienceDaily

— A team of UC researchers has found that mothers who had fevers

during their pregnancies were more than twice as likely to have a child

with autism or developmental delay than were mothers of typically

developing children, and that taking medication to treat fever

countered its effect.

"Our study provides strong evidence that

controlling fevers while pregnant may be effective in modifying the

risk of having a child with autism or developmental delay," said

Ousseny Zerbo, lead author of the study, who was a Ph.D. candidate with

UC when the study was conducted and is now a postdoctoral

researcher with the Kaiser Permanente Northern California Division of

Research. "We recommend that pregnant women who develop fever take

anti-pyretic medications and seek medical attention if their fever

persists."

Published online in the Journal of

Autism and Developmental Disorders, the study is believed to be the

first to consider how fever from any cause, including the flu, and its

treatment during pregnancy could affect the likelihood of having a

child with autism or developmental delay.

The results are based on data from a

large, case-control investigation known as the Childhood Autism Risk

from Genetics and the Environment (CHARGE) Study. Another recent study

based on CHARGE data found that mothers who were obese or diabetic had

a higher likelihood of having children with autism.

Irva Hertz-Picciotto, a professor of

public health sciences at UC and principal investigator of

CHARGE, pointed out that fever is produced by acute inflammation -- the

short-term, natural immune system reaction to infection or injury --

and that chronic inflammation, which no longer serves a beneficial

purpose and can damage healthy tissue, may be present in mothers with

metabolic abnormalities like diabetes and obesity.

"Since an inflammatory state in the body

accompanies obesity and diabetes as well as fever," said

Hertz-Picciotto, "the natural question is: Could inflammatory factors

play a role in autism?"

She explained that when people are

infected by bacteria or viruses, the body generally reacts by

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RESEARCH

Fever During Pregnancy More Than Doubles the Risk of Autism or

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