Coaxing the liver into preventing autoimmune disease in the brain

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In this issue of the JCI,

Lüth et al. report exciting data that illustrate the

far-reaching implications of this hepatic tolerance model. The

authors demonstrate that expression of MBP in the livers of mice via transgenic

and gene transfer approaches prevents the neuroinflammation

characteristic of EAE, providing what is believed to be the first evidence that

the tolerogenic potential of the liver can abrogate

development of autoimmune disease even if the target antigen for the

inflammatory T cell response is located in a distant organ, in this instance

the brain.

http://www.jci.org/articles/view/37079

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