Re:Infliximab and PSC

[Guest guest]

Dave-

Wasn't the s' (the STOP PSC people) son who was diagnosed at age

10 with PSC, treated with Infliximab infusions successfully? Either that

or do you suppose there's no reason other than a " miracle, " that he

shows absolutely no symptoms of PSC at age 17? I believe he has

continued to get Inflliximab infusions every six weeks for 7 years.

Thanks, as always, for your gazillion contributions to this group.

WOF (Wife of Fred), PSC 03/04, UC 03/06

[Guest guest]

Hi (WOF);

You are correct. As far as I know, he has Crohn's disease. So it is

possible that it is only those with Crohn's and PSC that respond well

to infliximab? This would be consistent with isolated reports such as

this:

Silbermintz A, Krishnan S, Banquet A, Markowitz J 2006 Granulomatous

pneumonitis, sclerosing cholangitis, and pancreatitis in a child with

Crohn disease: response to infliximab. J. Pediatr. Gastroenterol.

Nutr. 42: 324-326.

http://www.jpgn.org/pt/re/jpgn/fulltext.00005176-200603000-00015.htm

I havn't been able to get the full text of the Hommes et al (2008)

paper, but I would have to guess that most of the patients in their

trial might have had UC rather than Crohn's?

Best regards,

Dave R.