Re: Meg H.-would you help a red hatter out of her headache?

[Guest guest]

Hi ,

Now you're giveing me a headache! To me your question looks like not

only apples and oranges, but an entire fruit salad. The short answer

is, I can't even begin to address your questions. The longer answer

is, this is the sort of thing the research geneticists are really

looking into in depth now. I do clinical work - I'm not in the lab,

so much of the very technical stuff goes over my head, too.

Apparently, CHD genes have been known for a while - it is known that

they are regulatory (turn other genes on and off). Now that CHD7 is

known to cause CHARGE, a mouse model (a strain of mice missing the

mouse equivalent of human CHD7) has been developed. Researchers are

looking at A) are there particular mutations in humans that correlate

with particular features of CHARGE? what are features of CHD7

mutation mice? C) in what tissues is the CHD7 protein expressed, D)

What other genes are regulated by CHD7, and on and on. BIG BIG

questions. The Geneticists speaking at conference (Friday

afternoon)will talk about some of those things - ask them! The

answers to most of your questions will have to wait for more research.

Possibly many, many more years of research.

Meg

Meg Hefner MS

Genetic Counselor, St. Louis MO

>

> Could anything be simple-like perhaps a true correlation between

> zinc-finger proteins and available serum zinc levels in the body?

>

> I found one little blurb that suggests not,

> _http://www.springerlink.com/content/m813237457771082/_

(http://www.springerlink.com/content/m813237457771082/)

> stating that they islolated one case re: a yeast protein, where the

body

> manufactured binding structures using alternate amino acid

sequences. (if I read

> it right)

> Are Charge individuals resequencing amino acids, do you think?

> But I found other sites which seem to suggest that naturally there

is a

> correlation.

> ---

>

> (Are Charge individuals resequencing amino acids, do you think?)

> ----

>

> And, I'm sure I won't word this properly, but you may be able to get

my

> drift-

> does the mutation(s) exist in the zygote, so that the replication

process

> is true? Or

> is the error in the translation, transferance process?

> And what is the governor-the overseer of the translation process?

> ----

> I also saw your latest paper, I think, (and Tim's abstract), but

lost track

> of it. If it's conference

> material, I'll wait. Or, if you want....as I'm not conference

> bound....maybe you could tell

> me how to locate it again ;-)

> ----

> And maybe we don't know why repair genes aren't more interested in

Charge?

> ( I won't ask about stem cells-)

>

>

> Thanks Meg,

> in Ma.

>

>

>

> ************************************** See what's free at

http://www.aol.com.

>

>

>