re: GROWTH HORMONE in Charge -a recent article in Nature

[Guest guest]

I debated about sending this article I found and filed on Sunday, as it

seems a bit contrary to some opinions we've held.

But, if you have the article, then you can decide if you want to discuss it

with your child's doctor.

Nature is one of the most respected journals, so it shouldn't be

off-the-wall stuff.

(There is also a discussion of " Thermal dysregulation and irregularities of

cardiac rhythm are other signs of rhombencephalic dysfunction. "

A google of rombencephalic dysfunction brings up Charge and CHD7, so someone

may want to look

further at that.) I believe it's in relation to pain response.

Growth retardation

_http://www.nature.com/ejhg/journal/v15/n4/full/5201778a.html_

(http://www.nature.com/ejhg/journal/v15/n4/full/5201778a.html) 07 February

2007

Despite its presence in the original acronym, growth retardation is seldom a

primary problem in CHARGE syndrome. Most patients have low normal birth

weight and length (around 10th centile)._46_

(http://www.nature.com/ejhg/journal/v15/n4/full/5201778a.html#bib46) Postnatal

growth retardation should be in

relation to feeding difficulties and/or surgical problems._47_

(http://www.nature.com/ejhg/journal/v15/n4/full/5201778a.html#bib47) Growth

tends to catch up

after infancy, but insufficient and inadapted intakes may have adverse

outcome on growth and bone mineralization. Osteoporosis seems frequent in elder

patients with CHARGE, because of 'relative' malnutrition and insufficient

secretion of steroids. True GH deficiency is exceptional.

in Ma.

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