Guest guest Posted March 13, 2008 Report Share Posted March 13, 2008 Hi Val, Please take the time to read this, i would really appreciate it if you have the time. I know its long but you really know your stuff and its hard to find abybody with your level of knowledge and experience. So thanks a TON in advance. Okay i dont know if you remember my story, i posted my adrenals problems and test results recently, but im a 23 year old male, i have very low DHEA-S, very low morning Cortisol, and a high afternoon Cortisol rebound. I beleive when i used stimulants i burnt my adrenals out. I also want to note that my Estradiol was borderline high, and my Bioavailable Testosterone was high. I wonder if this has anything to do with Insulin Resistance or my Adrenal Fatigue. My thyroid levels were fine, but you said that low Cortisol can cause thyroid hormones to look higher in the blood than they really are. My case is confusing though since i have low morning, high afternoon, and normal evening and night Cortisol levels. At this time i got my adrenal saliva test i was using Finesteride ( for hairloss ), Letrozole to reduce Estrogen, and 25mcg of T3. My face has been puffy and bloated since my adrenals problems started last year, and my face has never been like this ever in my life. A few weeks before i took my adrenal test i was using Avodart ( for hairloss and is stronger than Finesteride ), 2.5mg of liquid Letrozole for Estrogen control, and 50mcg of T3 all in one dose before breakfast. After 3 days of this my puffy face went away and i was peeing a lot. This was the only thing that made my puffy face go away and i was so happy. My energy was also better, but i had anxiety, i was jittery and jumpy, i had major brain fog and felt like i was high on drugs or speed, but with a foggy brain. I wasnt calm and cool at all i was in hyper mode. But this was the only thing that worked to get rid of my puffy face. But after the 4th day i tapered off of this regimen due to these side effects and after my bloated/puffy face returned. My goal is to get my puffy face to go away again and to feel/look good again, but to not be jumpy, jittery, not have brain fog and anxiety,ect. I want to be calm and cool, but use my energy at will when i feel like it. Mabye adding Cortisol is the answer to this. Whatever happened to me it seems to NOT be going away because this happened to me in May/07 and my face just stayed bloated and puffy ever since. But you recommended 4 pellets of Isocort in the monrning with some DHEA. Well this either isnt working for me or i need thyroid aswell. I tried a few times using some armour or T3, but the effects of increased energy lasted for a coupole hours, then i felt like crap after, and my face remained puffy. So i ordered some Cortef and some Cytomel. I plan on using Avodart again for hairloss, and Letrozole to lower Estrogen, because Avodart reduces DHT, and DHT is a natural estrogen antagonist, and using Avodart without an Anti-Estrogen may cause high Estradiol. I also want to try 50mcg of T3 again as it worked in combination with the Avodart and Letrozole when i tried it before, but with the addition of Adrenal Support. 1. I was wondering how much Cortef should i use, and how should i dose it thoughout the day? Im going to work myself up to 50-60mcg of T3, but i want to have consistant energy levels and effects of the T3 without crashing or getting tired later in the day. I want to fully heal my adrenals and support them so they can handle the T3, and enough Cortisol to heal my adrenals. But i dont want my Cortisol levels too high as it will make me gain fat and all kinds of other problems. This seems VERY trickey to get the right dose,ect. I can almost swear that when i take Isocort, that my muscles get harder. Im naturally muscular and lean, but lately my muscles have been really hard, i seem to get really vascular and muscle pumped doing very small activities like shoveling the snow, and also it seems like i have either dry joints or high lactic acid as when i do something small like shover the snow or wash the dishes repeatedly, my muscles or joints burn as if i was lifting weights or something. I dont know what is the cause of this but this is absolutely not normal for me. Ive put on 14 pounds since this adrenal issue started, and i havent changed my lifestyle at all. Ive gained some muscle and abdominal and facail fat, and water retention. Its like my metabolism has slowed down but instead of just gaining fat im gaining a good amount of muscle aswell and im holding water. My blood pressure has also been high and borderline high. 2. In your experience, when a persons morning Cortisol is low, but high in the afternoon, does this usually mean that thyroid hormones appear higher in the blood than they actually are? The majority of the time? 3. I was thinking about taking this topical transdermal product called Dermacrine that contains DHEA and Pregnenolone. How would this effect somebody in my case with Adrenal fatigue? 4.How do these hormones effect the Adrenals, Cortisol, T3 and T4, and their availability to enter the cells? 5.What is DHEA's effect on Cortisol? Does it lower Cortisol?, raise Cortisol? Does it block Cortisols effects? 6.What about Pregnenolone? Does it convert to Cortisol and Progesterone? 7.Does Progesterone effect Cortisol or Thyroid in any way? 8. Does lowering Estrogen effect Cortisol or Thyroid in any way? Or the Adrenals? If you could please find the time to help answer these questions for me i would REALLY appreciate it. Im really trying to get a handle on this. Thanks so much Val! 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