Drugs From a Disease Used Differently-Eva's prospective

[Guest guest]

Geo

It costs $9 million to take any drug through the FDA protocol for

approval on one disease. Drug companies explain in painful detail

how the drug works in that situation. Our drug costs would be

through the roof if each and every disease showing the slightest

benefit had to go through the FDA expensive approach.

Doctors are allowed to think 'out of the box'. Depending on the

doctor ...well you know the intelligence mix.

Just in my life and research I have benefited from:

Quinine - anti-malarial because it stops muscle cramps and as I just

learned it increases the killing and shredding of EB virus

Aldactone - mild diuretic/bld pressure med that adds in correcting an

enzyme deficiency of adrenal hyperplasia.

Dexamethazone - used to maintain balance of cortisol in adrenal

hyperplasia but recently found to inhibit anti-neuronal antibodies.

Celebrex - COX-2 enzyme inhibitor used in arthritis (OA &RA) and FDA

approved for reduction of colorectal polp disease - also shown to

improve quality of life issues in MND without measurable prognosis

factors....just learned this new stuff last night... Fulminating EBV

infections also causes the body to start an autoimmune response

against its own neuron, nephrons, retina and more. This Autoimmune

response 'upregulates COX-2 enyzme' (makes more COX-2). So not even

knowing what they were doing but only listening to patient response.

ALS Center started putting certain patients (me) on the higher RA

doses of Celebrex.......which was keeping the increases in COX-2

caused by EBV in check.

Call it like you see it!! In my situation right now I call it all

Divine Intervention!!!!

Gang, I could SING this morning. I'm using half my usualy

Zanaflex...no Provigil. I've dropped 10 pounds. No more

swelling...without taking the diuretic RX.

And check this out

Remember the iRNA video. Check out this abstract

Virology. 2006 Mar 15;346(2):385-93. Epub 2005 Dec 15. Related

Articles, Links

siRNAs against the Epstein Barr virus latency replication factor,

EBNA1,

inhibit its function and growth of EBV-dependent tumor cells.

Yin Q, Flemington EK.

Tulane Health Sciences Center and Tulane Cancer Center, Department of

Pathology, SL79, 1430 Tulane Avenue, New Orleans, LA 70112, USA.

The Epstein Barr virus (EBV) plays a role in maintenance of the tumor

phenotype in a number of human cancers. The EBV latency replication

factor,

EBNA1, is required for persistence of the EBV episome, is anti-

apoptotic,

and is universally expressed in all EBV-associated tumors. Here, we

show

that EBNA1-specific siRNAs can inhibit EBNA1 expression and function

siRNAs

were generated against three target sites in the EBNA1 messenger RNA,

and

two of these were found to inhibit EBNA1 expression from an ectopic

EBNA1

expression cassette. EBNA1 siRNAs also inhibit endogenously expressed

EBNA1

in EBV-positive epithelial and B-cell lines. Using a mini-EBV

replication

model, siRNA-mediated inhibition of EBNA1 expression suppressed the

episomal

maintenance function of EBNA1. Lastly, introduction of an EBNA1 siRNA

into

an EBV-positive tumor cell line inhibited tumor cell growth/survival.

These

data suggest that siRNAs against EBNA1 may have therapeutic value in

EBV-associated diseases.

PMID: 16343579 [PubMed - in process]

[Guest guest]

So Let me see ,We do the same thing in Medicine that we do with the

American Auto Worker or Union Man > we ship it out of the US and it

automatically is 50% Less .So now were at $4.5 Mil.But Oh i forgot

We in the US cannot think for ourselves and sign a release form

We Need a Law that states if i screw up and get hurt its not my

fault ,Its your Fault, or anyone besides me. So now we end up Where

nothing can be made in the US without tremendous cost.Isnt this

where the Crux of the problem is??? No one would complain about

paying you as a Lab Tech or whatever to do your work. So some docs.

at their discretion can become God Like and decide who gets Quality

Care and Who Doesnt. SOMEONE STILL NEEDS TO STEP UP TO THE PLATE

GEO

>

> Geo

> It costs $9 million to take any drug through the FDA protocol for

> approval on one disease. Drug companies explain in painful detail

> how the drug works in that situation. Our drug costs would be

> through the roof if each and every disease showing the slightest

> benefit had to go through the FDA expensive approach.

> Doctors are allowed to think 'out of the box'. Depending on the

> doctor ...well you know the intelligence mix.

>

> Just in my life and research I have benefited from:

> Quinine - anti-malarial because it stops muscle cramps and as I

just

> learned it increases the killing and shredding of EB virus

>

> Aldactone - mild diuretic/bld pressure med that adds in correcting

an

> enzyme deficiency of adrenal hyperplasia.

>

> Dexamethazone - used to maintain balance of cortisol in adrenal

> hyperplasia but recently found to inhibit anti-neuronal antibodies.

>

> Celebrex - COX-2 enzyme inhibitor used in arthritis (OA &RA) and

FDA

> approved for reduction of colorectal polp disease - also shown to

> improve quality of life issues in MND without measurable prognosis

> factors....just learned this new stuff last night... Fulminating

EBV

> infections also causes the body to start an autoimmune response

> against its own neuron, nephrons, retina and more. This Autoimmune

> response 'upregulates COX-2 enyzme' (makes more COX-2). So not

even

> knowing what they were doing but only listening to patient

response.

> ALS Center started putting certain patients (me) on the higher RA

> doses of Celebrex.......which was keeping the increases in COX-2

> caused by EBV in check.

>

> Call it like you see it!! In my situation right now I call it all

> Divine Intervention!!!!

> Gang, I could SING this morning. I'm using half my usualy

> Zanaflex...no Provigil. I've dropped 10 pounds. No more

> swelling...without taking the diuretic RX.

> And check this out

> Remember the iRNA video. Check out this abstract

>

> Virology. 2006 Mar 15;346(2):385-93. Epub 2005 Dec 15.

Related

> Articles, Links

>

>

> siRNAs against the Epstein Barr virus latency replication factor,

> EBNA1,

> inhibit its function and growth of EBV-dependent tumor cells.

>

> Yin Q, Flemington EK.

>

> Tulane Health Sciences Center and Tulane Cancer Center, Department

of

> Pathology, SL79, 1430 Tulane Avenue, New Orleans, LA 70112, USA.

>

> The Epstein Barr virus (EBV) plays a role in maintenance of the

tumor

> phenotype in a number of human cancers. The EBV latency

replication

> factor,

> EBNA1, is required for persistence of the EBV episome, is anti-

> apoptotic,

> and is universally expressed in all EBV-associated tumors. Here,

we

> show

> that EBNA1-specific siRNAs can inhibit EBNA1 expression and

function

> siRNAs

> were generated against three target sites in the EBNA1 messenger

RNA,

> and

> two of these were found to inhibit EBNA1 expression from an

ectopic

> EBNA1

> expression cassette. EBNA1 siRNAs also inhibit endogenously

expressed

> EBNA1

> in EBV-positive epithelial and B-cell lines. Using a mini-EBV

> replication

> model, siRNA-mediated inhibition of EBNA1 expression suppressed

the

> episomal

> maintenance function of EBNA1. Lastly, introduction of an EBNA1

siRNA

> into

> an EBV-positive tumor cell line inhibited tumor cell

growth/survival.

> These

> data suggest that siRNAs against EBNA1 may have therapeutic value

in

> EBV-associated diseases.

>

> PMID: 16343579 [PubMed - in process]

>