Re: Plant estrogens in soy, legumes, affects on cycle length

[Guest guest]

FYI i sent this to Gabi in response to her question

about menstral cycle length being affected by plant

estrogens (i.e. soy, hummus, ...)

Gabi, -I would definitely talk to your doctor about

other (non-soy) sources of your menstral cycle delay

which could be far more meaningful-

The evidence is generally quite negative for

significant effects of isoflavones (plant estrogens)

on menstrual cycle length (see below, only two studies

are positive and they increased cycle length by only a

few days). and better to be safe than sorry, i would

also encourage all people undergoing fertility

treatment to avoid Pueraria mirifica, a Thai herb

containing phytoestrogens, may act as estrogen and

disturb reproduction-- in general i would avoid all

those natural things they sell in whole foods stores

that claim to increase fertility etc- they are not

scientifically studied and may have negative effects.

Brown et al Nutr Cancer. 2002;43(1):22-30.

The soy diet slightly increased menstrual cycle length

by 1.8 +/- 0.7 days (P = 0.088)

Kurzer MS et al J Nutr. 2002 Mar;132(3):570S-573S.

Hormonal effects of soy in premenopausal women and

men.

....These studies provided 32-200 mg/d of isoflavones

and generally showed decreased midcycle plasma

gonadotropins and **trends** toward increased

menstrual cycle length and decreased blood

concentrations of estradiol, progesterone and sex

hormone-binding globulin. [GABI:

" TREND " MEANS NOT STATISTICALLY SIGNIFICANT FINDINGS]

Maskarinec G et al Cancer Epidemiol Biomarkers Prev.

2002 Feb;11(2):195-201.

.... Menstrual cycle length did not change

significantly during the [isolflavone dietary] trial

....

Lu et al Cancer Res. 2000 Aug 1;60(15):4112-21.

Decreased ovarian hormones during a soya diet:

implications for breast cancer prevention.

....Mean menstrual cycle length did NOT change during

the soya diet; a slight decrease in mean luteal cycle

length was marginally statistically significant (P =

0.06).

i MC et al. Nutr Cancer. 1999;34(2):133-9.

Effects of soy intake on sex hormone metabolism in

premenopausal women.

....NO significant differences were observed in serum

estrone, estradiol, sex hormone-binding globulin,

dehydroepiandrosterone sulfate, prolactin, or

progesterone concentrations with soy feeding in the

non-OC or the OC group. ***No changes in menstrual

cycle length or the urinary estrogen metabolite ratio

of 2-hydroxyestrone to 16 alpha-hydroxyestrone were

seen with soy feeding in the non-OC or the OC

group.***

Nagata C et al J Natl Cancer Inst. 1998 Dec

2;90(23):1830-5.

..... In the soymilk-supplemented group, menstrual

cycle length was increased by nearly 2 days, and, in

the control group, it was decreased by approximately 1

day, a difference that was NOT statistically

significant.

Cassidy A et al Br J Nutr. 1995 Oct;74(4):587-601.

Biological effects of isoflavones in young women:

importance of the chemical composition of soyabean

products.

.... The increase in menstrual cycle length did NOT

reach statistical significance in the three three

subject who ate 50 g miso/d, but peak progesterone

levels were significantly (P < 0.05) delayed.

Mid-cycle peaks of luteinizing hormone (LH) and

follicle stimulating hormone (FSH) were suppressed

with 45 mg conjugated isoflavones as 60 g TVP (P <

0.05 and P < 0.01 respectively).

Cassidy A et al Am J Clin Nutr. 1994 Sep;60(3):333-40.

Biological effects of a diet of soy protein rich

in isoflavones on the menstrual cycle of premenopausal

women.

...Soy protein (60 g containing 45 mg isoflavones)

given daily for 1 mo **significantly (P < 0.01)

increased*** follicular phase length and/or *delayed

menstruation.* Midcycle surges of luteinizing hormone

and follicle-stimulating hormone were significantly

suppressed during dietary intervention with soy

protein. Plasma estradiol concentrations increased in

the follicular phase and cholesterol concentrations

decreased 9.6%. ... NOTE THIS IS PROBABLY ONLY BY A

FEW DAYS- AND ALSO IS THE OLDEST STUDY OUT THERE SO

PROBABLY THE WEAKEST METHODS OF ALL THE STUIDES OUT

THERE

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