Guest guest Posted January 30, 2004 Report Share Posted January 30, 2004 , The closest I have heard about this is removing the " yolk " part of the egg and replacing it to allow a child to have 3 parents. Two mothers and one father. They are having trouble getting nuclear dna to go to the right spot but are currently using a retro virus to take it in. I think right now the task of replacing mito in every cell of our body is just beyond our science. Twana > why they couldn't just give me a > transfusion of mitochondrial Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 3, 2004 Report Share Posted February 3, 2004 See an orthodontist and/or an oral and maxillofacial surgeon. They are the ones who know. For me, I was having some TMJ trouble. I was having some serious periodontal disease -- but I think that might have been avoided had I known to have the ortho and the surgery earlier. I was apparently wearing the dickens out of my back teeth. Other things that may (or may not) suggest it: if your lower jaw is notably shorter than your upper. (I never have had much of a chin). Or if it is notably longer -- a lantern jaw, or a " jay leno " jaw. None of this means you DO need the surgery, and none of it means that the surgery will be confined to the lower jaw, necessarily. The opinions about how to fix things can change during the course of the ortho prep for surgery, too. In short, you need some expert opinions, and then ask your experts whether they recommend an operation, what they recommend and any other questions you have. Something must have suggested this to you. What is it? Most of us don't just wake up one morning and say, " Hey. I need to have my face rearranged! ;~) Good wishes to you, in any case. Cammie > How do you know if you have to have Lower Jaw Surgery like what are > the symptoms??just curious Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 7, 2004 Report Share Posted April 7, 2004 Hi Vicky, That is not at all a silly question and it's one that I don't think anyone has the final answer to, because there is still so much for the doctors and researchers to learn about mitochondrial disorder. But, I have heard from 2 experts in mitochondrial disorders that there are a number of mitochondrial disorders that DON"T result in deterioration and death. There are also some mitochondrial disorders that do end up in cognitive deterioration and death before adulthood. This "almost normal" thing is something we talk a lot about here and it's something I'm currently dealing with with my little guy. Anne R Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 7, 2004 Report Share Posted April 7, 2004 Hi Vicky, That is not at all a silly question and it's one that I don't think anyone has the final answer to, because there is still so much for the doctors and researchers to learn about mitochondrial disorder. But, I have heard from 2 experts in mitochondrial disorders that there are a number of mitochondrial disorders that DON"T result in deterioration and death. There are also some mitochondrial disorders that do end up in cognitive deterioration and death before adulthood. This "almost normal" thing is something we talk a lot about here and it's something I'm currently dealing with with my little guy. Anne R Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 7, 2004 Report Share Posted April 7, 2004 Hi Vicky, That is not at all a silly question and it's one that I don't think anyone has the final answer to, because there is still so much for the doctors and researchers to learn about mitochondrial disorder. But, I have heard from 2 experts in mitochondrial disorders that there are a number of mitochondrial disorders that DON"T result in deterioration and death. There are also some mitochondrial disorders that do end up in cognitive deterioration and death before adulthood. This "almost normal" thing is something we talk a lot about here and it's something I'm currently dealing with with my little guy. Anne R Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 7, 2004 Report Share Posted April 7, 2004 To ease your mind, No. Although there are some types were death is almost inevitable. From an article I just read that quoted Dr. Cohen, only about 10-15% are fatal. Unfortunately, I believe, the death rate is much higher due to misdiagnosing. Also with some children the symptoms are so subtle that they are overlooked until it is too late. In these cases it is nobodies fault, the disease is just so unknown. I am pretty confident that my daughter would not have lived into her childhood if it were not for being diagnosed and started on the cocktail. Now being medicated and watched, she has a positive future. Her doctors often have different views on her health, but none believe that she will die from this. Of course every child is different and some do not do as well as others. I just wanted you to understand that without the proper diagnosis and treatment my child would not be running and playing like she is today. I still feel so bad everyday for the parents who have lost there children to this disease. I hope this is some reassurance to you. I have gone through the same issues you are dealing with now. Just try to be positive and focus on your child's abilities and accomplishments, no matter how small the progress it is progress. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 7, 2004 Report Share Posted April 7, 2004 To ease your mind, No. Although there are some types were death is almost inevitable. From an article I just read that quoted Dr. Cohen, only about 10-15% are fatal. Unfortunately, I believe, the death rate is much higher due to misdiagnosing. Also with some children the symptoms are so subtle that they are overlooked until it is too late. In these cases it is nobodies fault, the disease is just so unknown. I am pretty confident that my daughter would not have lived into her childhood if it were not for being diagnosed and started on the cocktail. Now being medicated and watched, she has a positive future. Her doctors often have different views on her health, but none believe that she will die from this. Of course every child is different and some do not do as well as others. I just wanted you to understand that without the proper diagnosis and treatment my child would not be running and playing like she is today. I still feel so bad everyday for the parents who have lost there children to this disease. I hope this is some reassurance to you. I have gone through the same issues you are dealing with now. Just try to be positive and focus on your child's abilities and accomplishments, no matter how small the progress it is progress. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 7, 2004 Report Share Posted April 7, 2004 To ease your mind, No. Although there are some types were death is almost inevitable. From an article I just read that quoted Dr. Cohen, only about 10-15% are fatal. Unfortunately, I believe, the death rate is much higher due to misdiagnosing. Also with some children the symptoms are so subtle that they are overlooked until it is too late. In these cases it is nobodies fault, the disease is just so unknown. I am pretty confident that my daughter would not have lived into her childhood if it were not for being diagnosed and started on the cocktail. Now being medicated and watched, she has a positive future. Her doctors often have different views on her health, but none believe that she will die from this. Of course every child is different and some do not do as well as others. I just wanted you to understand that without the proper diagnosis and treatment my child would not be running and playing like she is today. I still feel so bad everyday for the parents who have lost there children to this disease. I hope this is some reassurance to you. I have gone through the same issues you are dealing with now. Just try to be positive and focus on your child's abilities and accomplishments, no matter how small the progress it is progress. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 7, 2004 Report Share Posted April 7, 2004 Dear Vicki,  You asked a very difficult question. I don’t know if there truly is an answer. It depends on so many factors, like the form of mito they have etc.  Even children with the same exact form can have different results. You can look at the statistics, but always keep in mind that this is not a for sure thing. So little is known about mito even now that doctors cannot make accurate predictions. I recently read that only 10-15% of mito is fatal. Therefore, there are many people with mito that do not die. However, from my experience and from my rsearch, the younger they are when they show symptoms, and the more severe the symptoms, the worse the prognosis. EXCEPT, not always. My daughters both have a very severe form of mito. My older one, Samya, live 8 years and looked very ‘Normal’. In fact, she was never diagnosed until 2 weeks before she died. If you told me she had a disease that would take her life in less than 2 months only 2 months before she died, I would NEVER have believed it at all. I always knew my daughter had something wrong with her, but never ever thought it was deadly. She deteriorated very quickly. Went to the hospital one day, never came home, and died 33 days later. Some children are in and out of hospitals for years before they die. Each child is different. My doctors said the form my girls have should have killed them between 18 months to 3 years. HONEST. Samya made it to a wonderful 8 years and 8 months. Leanna, my younger one, has the same form. She will turn 7 in May. She looks very normal too. Neither one ever had seizures or any major medical problems. However, I see Leanna deteriorating and I know from experience how quickly she can die. I know most mito kids who have a severe form don’t make it to teen years. But I also have seen exceptions everywhere, So the answer is there is no answer. My advice to you is to enjoy evert day with your child and you will only know the future as it comes along. Do not waste energy (easy to say I know) today worrying about it and end up losing out on his health today. You can see my girls on the website www.samya.org .   I don not blame you for your question and I wish there was a definite answer. I think it every day about Leanna. But, I look back at Samya’s life and wonder if it would have been better to have known she would die or not. We treated her like she would live forever. Some is good and some not. Now I know that Leanna is more likely to die than live. I truly don’t know what is worse. Both are hard. My prayers to you.                                                                                Enjoy your precious son. May God bless you, Suhad Haddad -- Mom to Samya (Died 12-10-02 of Leigh's Synd.) & Leanna with same disease. Samya's Memorial Site: www.Samya.org Email: Suhad1970@... Alt Email: Suhad@... AiM Chat: Suhad1970 From: Vicky Castro Sent: Wednesday, April 07, 2004 9:53 AM To: Mito Subject: Question Hello everyone: As you all know I am new to this group. I am Felipe´s monther, a six month´s old baby from Colombia with mito. I have a very silly question for you today and it come out my total ignorance about the issue. Are our mito kids inevitably going to die before they get to adulthood? I see my son almost normal that I can not belive it. Do they deteriorate inevitably? Best regards, Vicky Castro, Felipe´s mom Please contact mito-owner with any problems or questions. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 7, 2004 Report Share Posted April 7, 2004 Dear Vicki,  You asked a very difficult question. I don’t know if there truly is an answer. It depends on so many factors, like the form of mito they have etc.  Even children with the same exact form can have different results. You can look at the statistics, but always keep in mind that this is not a for sure thing. So little is known about mito even now that doctors cannot make accurate predictions. I recently read that only 10-15% of mito is fatal. Therefore, there are many people with mito that do not die. However, from my experience and from my rsearch, the younger they are when they show symptoms, and the more severe the symptoms, the worse the prognosis. EXCEPT, not always. My daughters both have a very severe form of mito. My older one, Samya, live 8 years and looked very ‘Normal’. In fact, she was never diagnosed until 2 weeks before she died. If you told me she had a disease that would take her life in less than 2 months only 2 months before she died, I would NEVER have believed it at all. I always knew my daughter had something wrong with her, but never ever thought it was deadly. She deteriorated very quickly. Went to the hospital one day, never came home, and died 33 days later. Some children are in and out of hospitals for years before they die. Each child is different. My doctors said the form my girls have should have killed them between 18 months to 3 years. HONEST. Samya made it to a wonderful 8 years and 8 months. Leanna, my younger one, has the same form. She will turn 7 in May. She looks very normal too. Neither one ever had seizures or any major medical problems. However, I see Leanna deteriorating and I know from experience how quickly she can die. I know most mito kids who have a severe form don’t make it to teen years. But I also have seen exceptions everywhere, So the answer is there is no answer. My advice to you is to enjoy evert day with your child and you will only know the future as it comes along. Do not waste energy (easy to say I know) today worrying about it and end up losing out on his health today. You can see my girls on the website www.samya.org .   I don not blame you for your question and I wish there was a definite answer. I think it every day about Leanna. But, I look back at Samya’s life and wonder if it would have been better to have known she would die or not. We treated her like she would live forever. Some is good and some not. Now I know that Leanna is more likely to die than live. I truly don’t know what is worse. Both are hard. My prayers to you.                                                                                Enjoy your precious son. May God bless you, Suhad Haddad -- Mom to Samya (Died 12-10-02 of Leigh's Synd.) & Leanna with same disease. Samya's Memorial Site: www.Samya.org Email: Suhad1970@... Alt Email: Suhad@... AiM Chat: Suhad1970 From: Vicky Castro Sent: Wednesday, April 07, 2004 9:53 AM To: Mito Subject: Question Hello everyone: As you all know I am new to this group. I am Felipe´s monther, a six month´s old baby from Colombia with mito. I have a very silly question for you today and it come out my total ignorance about the issue. Are our mito kids inevitably going to die before they get to adulthood? I see my son almost normal that I can not belive it. Do they deteriorate inevitably? Best regards, Vicky Castro, Felipe´s mom Please contact mito-owner with any problems or questions. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 7, 2004 Report Share Posted April 7, 2004 Dear Vicki,  You asked a very difficult question. I don’t know if there truly is an answer. It depends on so many factors, like the form of mito they have etc.  Even children with the same exact form can have different results. You can look at the statistics, but always keep in mind that this is not a for sure thing. So little is known about mito even now that doctors cannot make accurate predictions. I recently read that only 10-15% of mito is fatal. Therefore, there are many people with mito that do not die. However, from my experience and from my rsearch, the younger they are when they show symptoms, and the more severe the symptoms, the worse the prognosis. EXCEPT, not always. My daughters both have a very severe form of mito. My older one, Samya, live 8 years and looked very ‘Normal’. In fact, she was never diagnosed until 2 weeks before she died. If you told me she had a disease that would take her life in less than 2 months only 2 months before she died, I would NEVER have believed it at all. I always knew my daughter had something wrong with her, but never ever thought it was deadly. She deteriorated very quickly. Went to the hospital one day, never came home, and died 33 days later. Some children are in and out of hospitals for years before they die. Each child is different. My doctors said the form my girls have should have killed them between 18 months to 3 years. HONEST. Samya made it to a wonderful 8 years and 8 months. Leanna, my younger one, has the same form. She will turn 7 in May. She looks very normal too. Neither one ever had seizures or any major medical problems. However, I see Leanna deteriorating and I know from experience how quickly she can die. I know most mito kids who have a severe form don’t make it to teen years. But I also have seen exceptions everywhere, So the answer is there is no answer. My advice to you is to enjoy evert day with your child and you will only know the future as it comes along. Do not waste energy (easy to say I know) today worrying about it and end up losing out on his health today. You can see my girls on the website www.samya.org .   I don not blame you for your question and I wish there was a definite answer. I think it every day about Leanna. But, I look back at Samya’s life and wonder if it would have been better to have known she would die or not. We treated her like she would live forever. Some is good and some not. Now I know that Leanna is more likely to die than live. I truly don’t know what is worse. Both are hard. My prayers to you.                                                                                Enjoy your precious son. May God bless you, Suhad Haddad -- Mom to Samya (Died 12-10-02 of Leigh's Synd.) & Leanna with same disease. Samya's Memorial Site: www.Samya.org Email: Suhad1970@... Alt Email: Suhad@... AiM Chat: Suhad1970 From: Vicky Castro Sent: Wednesday, April 07, 2004 9:53 AM To: Mito Subject: Question Hello everyone: As you all know I am new to this group. I am Felipe´s monther, a six month´s old baby from Colombia with mito. I have a very silly question for you today and it come out my total ignorance about the issue. Are our mito kids inevitably going to die before they get to adulthood? I see my son almost normal that I can not belive it. Do they deteriorate inevitably? Best regards, Vicky Castro, Felipe´s mom Please contact mito-owner with any problems or questions. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 7, 2004 Report Share Posted April 7, 2004 Hi Vicky, I am sure others will answer this question much better than I, but no, not all Mito children die. I just wanted you to know that they don't all die before they get to adulthood. Shirley, mom to and Jordan, Mito Myopathy On Wednesday, April 7, 2004, at 09:53 AM, Vicky Castro wrote: > Hello everyone: >  > As you all know I am new to this group. I am Felipe´s monther, a six > month´s old baby from Colombia with mito. >  > I have a very silly question for you today and it come out my total > ignorance about the issue. >  > Are our mito kids inevitably going to die before they get to adulthood? > I see my son almost normal that I can not belive it. Do they > deteriorate inevitably? >  > Best regards, >  > Vicky Castro, Felipe´s mom > > > Please contact mito-owner with any problems or > questions. > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 7, 2004 Report Share Posted April 7, 2004 Hi Vicky, I am sure others will answer this question much better than I, but no, not all Mito children die. I just wanted you to know that they don't all die before they get to adulthood. Shirley, mom to and Jordan, Mito Myopathy On Wednesday, April 7, 2004, at 09:53 AM, Vicky Castro wrote: > Hello everyone: >  > As you all know I am new to this group. I am Felipe´s monther, a six > month´s old baby from Colombia with mito. >  > I have a very silly question for you today and it come out my total > ignorance about the issue. >  > Are our mito kids inevitably going to die before they get to adulthood? > I see my son almost normal that I can not belive it. Do they > deteriorate inevitably? >  > Best regards, >  > Vicky Castro, Felipe´s mom > > > Please contact mito-owner with any problems or > questions. > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 7, 2004 Report Share Posted April 7, 2004 Hi Vicky, I am sure others will answer this question much better than I, but no, not all Mito children die. I just wanted you to know that they don't all die before they get to adulthood. Shirley, mom to and Jordan, Mito Myopathy On Wednesday, April 7, 2004, at 09:53 AM, Vicky Castro wrote: > Hello everyone: >  > As you all know I am new to this group. I am Felipe´s monther, a six > month´s old baby from Colombia with mito. >  > I have a very silly question for you today and it come out my total > ignorance about the issue. >  > Are our mito kids inevitably going to die before they get to adulthood? > I see my son almost normal that I can not belive it. Do they > deteriorate inevitably? >  > Best regards, >  > Vicky Castro, Felipe´s mom > > > Please contact mito-owner with any problems or > questions. > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 7, 2004 Report Share Posted April 7, 2004 Hi Anne Do you know what mito diseases don't end up in death? My son is 14, and is severely affected, but I was just wondering if you knew. thanks mom to Colby,13,COXIV,LCHAD,ACC,ADHD ,hypothroidism and osteopenia. Chad, 16, healthy, Caleb, 10, also healthy>From: AReckling@... >Reply-To: Mito >To: Mito >Subject: Re: Question >Date: Wed, 7 Apr 2004 14:03:43 EDT > >Hi Vicky, > >That is not at all a silly question and it's one that I don't think anyone >has the final answer to, because there is still so much for the doctors and >researchers to learn about mitochondrial disorder. But, I have heard from 2 >experts in mitochondrial disorders that there are a number of mitochondrial >disorders that DON"T result in deterioration and death. There are also some >mitochondrial disorders that do end up in cognitive deterioration and death before >adulthood. > >This "almost normal" thing is something we talk a lot about here and it's >something I'm currently dealing with with my little guy. > >Anne R Watch LIVE baseball games on your computer with MLB.TV, included with MSN Premium! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 7, 2004 Report Share Posted April 7, 2004 Hi Anne Do you know what mito diseases don't end up in death? My son is 14, and is severely affected, but I was just wondering if you knew. thanks mom to Colby,13,COXIV,LCHAD,ACC,ADHD ,hypothroidism and osteopenia. Chad, 16, healthy, Caleb, 10, also healthy>From: AReckling@... >Reply-To: Mito >To: Mito >Subject: Re: Question >Date: Wed, 7 Apr 2004 14:03:43 EDT > >Hi Vicky, > >That is not at all a silly question and it's one that I don't think anyone >has the final answer to, because there is still so much for the doctors and >researchers to learn about mitochondrial disorder. But, I have heard from 2 >experts in mitochondrial disorders that there are a number of mitochondrial >disorders that DON"T result in deterioration and death. There are also some >mitochondrial disorders that do end up in cognitive deterioration and death before >adulthood. > >This "almost normal" thing is something we talk a lot about here and it's >something I'm currently dealing with with my little guy. > >Anne R Watch LIVE baseball games on your computer with MLB.TV, included with MSN Premium! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 7, 2004 Report Share Posted April 7, 2004 Dear Vickie My son Colby, just celebrated his 14 birthday! When he was born, they told us he would not live to be 2. While we have nearly lost him numerous times, he fights back like the energizer bunny. I remember our geneticist telling us that at certain ages in our life we shed off old cells and produce new ones. He felt that at some point Colby's bad cells would overcome the good. It hasn't happened yet, but we fear puberty. Colby is severely affected since birth. You will find yourself growing in ways you never thought you would, you won't live the same life, but your new one will be better. After 14 years I guess I have just been thru it all, and maybe not everyone goes thru the same thing. Just love little Felipe everyday of his life and live for the moment... God Bless mom to Colby,14,COXIV,LCHAD,ACC,ADHD ,hypothroidism and osteopenia. Chad, 16, healthy, Caleb, 11 also healthy> >Reply-To: Mito >To: Mito >Subject: Question >Date: Wed, 07 Apr 2004 11:53:12 -0500 > >Hello everyone: > >As you all know I am new to this group. I am Felipe´s monther, a six month´s old baby from Colombia with mito. > >I have a very silly question for you today and it come out my total ignorance about the issue. > >Are our mito kids inevitably going to die before they get to adulthood? I see my son almost normal that I can not belive it. Do they deteriorate inevitably? > >Best regards, > >Vicky Castro, Felipe´s mom MSN Toolbar provides one-click access to Hotmail from any Web page – FREE download! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 7, 2004 Report Share Posted April 7, 2004 Dear Vickie My son Colby, just celebrated his 14 birthday! When he was born, they told us he would not live to be 2. While we have nearly lost him numerous times, he fights back like the energizer bunny. I remember our geneticist telling us that at certain ages in our life we shed off old cells and produce new ones. He felt that at some point Colby's bad cells would overcome the good. It hasn't happened yet, but we fear puberty. Colby is severely affected since birth. You will find yourself growing in ways you never thought you would, you won't live the same life, but your new one will be better. After 14 years I guess I have just been thru it all, and maybe not everyone goes thru the same thing. Just love little Felipe everyday of his life and live for the moment... God Bless mom to Colby,14,COXIV,LCHAD,ACC,ADHD ,hypothroidism and osteopenia. Chad, 16, healthy, Caleb, 11 also healthy> >Reply-To: Mito >To: Mito >Subject: Question >Date: Wed, 07 Apr 2004 11:53:12 -0500 > >Hello everyone: > >As you all know I am new to this group. I am Felipe´s monther, a six month´s old baby from Colombia with mito. > >I have a very silly question for you today and it come out my total ignorance about the issue. > >Are our mito kids inevitably going to die before they get to adulthood? I see my son almost normal that I can not belive it. Do they deteriorate inevitably? > >Best regards, > >Vicky Castro, Felipe´s mom MSN Toolbar provides one-click access to Hotmail from any Web page – FREE download! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 7, 2004 Report Share Posted April 7, 2004 Dear Vickie My son Colby, just celebrated his 14 birthday! When he was born, they told us he would not live to be 2. While we have nearly lost him numerous times, he fights back like the energizer bunny. I remember our geneticist telling us that at certain ages in our life we shed off old cells and produce new ones. He felt that at some point Colby's bad cells would overcome the good. It hasn't happened yet, but we fear puberty. Colby is severely affected since birth. You will find yourself growing in ways you never thought you would, you won't live the same life, but your new one will be better. After 14 years I guess I have just been thru it all, and maybe not everyone goes thru the same thing. Just love little Felipe everyday of his life and live for the moment... God Bless mom to Colby,14,COXIV,LCHAD,ACC,ADHD ,hypothroidism and osteopenia. Chad, 16, healthy, Caleb, 11 also healthy> >Reply-To: Mito >To: Mito >Subject: Question >Date: Wed, 07 Apr 2004 11:53:12 -0500 > >Hello everyone: > >As you all know I am new to this group. I am Felipe´s monther, a six month´s old baby from Colombia with mito. > >I have a very silly question for you today and it come out my total ignorance about the issue. > >Are our mito kids inevitably going to die before they get to adulthood? I see my son almost normal that I can not belive it. Do they deteriorate inevitably? > >Best regards, > >Vicky Castro, Felipe´s mom MSN Toolbar provides one-click access to Hotmail from any Web page – FREE download! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 8, 2004 Report Share Posted April 8, 2004 It depends upon the genetics involved in *your* kids' Mito! If it is Mitochondrial DNA that is the problem, then your daughters can pass it along to her sons and daughters, but your sons cannot .... this is because the tail of the sperm ( where the mitochondria are located so that spermie can do the swimming ) falls off and doesn't penetrate the egg ... so the male mitochondria don't imprint on the egg. This is called a "Maternal Inheritance" pattern. If it is Nuclear DNA that is your problem (the nucleus is the "boss" in the cell and if it has a problem, then it doesn't provide the mitochondria with the right materials to operate its factory properly) then both your sons and your daugters have the potential of passing along your brand of Mitochondrial Disease. Remember the Mendelian Inheritance in high school biology ... and the fruit flies? Well ... with Nuclear DNA inheritance you can have a number of combinations, depending upon whether your kind of Mito has a dominant genetic pattern or a recessive pattern. If you go to <http://umdf.org/> and then to "Information" and choose "For parents and families" you will be able to click on a page called "Genetics" .... and this page will explain it with diagrams, which I can't do on a post!!! Your question isn't weird or silly or anything negative!!!! It is the question of a concerned mom! It might be a very good idea for you to ask these questions of your Mito doc ... or ask for a referral to a geneticist. Since each Mito problem is specific to the patient .... it should be someone familiar with YOUR diagnosis who gives you the real answer! However ..... asking the question .... "Is my child's Mito caused by a problem with the Mitochondrial DNA or the Nuclear DNA?" is the place to start. Then ... if Nuclear ... ask whether the problem is "autosomal DOMINANT or RECESSIVE". Once you have those answers from the doctor .... go to the UMDF website (see above link explanation) and do some reading ... and then ask more questions if you need to! Jean mswims2007 wrote: This might seem like a weird question, but I have to ask it. If our kids have this disease and they grow up and get married and want to have children, will their children get this disease? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 8, 2004 Report Share Posted April 8, 2004 It depends upon the genetics involved in *your* kids' Mito! If it is Mitochondrial DNA that is the problem, then your daughters can pass it along to her sons and daughters, but your sons cannot .... this is because the tail of the sperm ( where the mitochondria are located so that spermie can do the swimming ) falls off and doesn't penetrate the egg ... so the male mitochondria don't imprint on the egg. This is called a "Maternal Inheritance" pattern. If it is Nuclear DNA that is your problem (the nucleus is the "boss" in the cell and if it has a problem, then it doesn't provide the mitochondria with the right materials to operate its factory properly) then both your sons and your daugters have the potential of passing along your brand of Mitochondrial Disease. Remember the Mendelian Inheritance in high school biology ... and the fruit flies? Well ... with Nuclear DNA inheritance you can have a number of combinations, depending upon whether your kind of Mito has a dominant genetic pattern or a recessive pattern. If you go to <http://umdf.org/> and then to "Information" and choose "For parents and families" you will be able to click on a page called "Genetics" .... and this page will explain it with diagrams, which I can't do on a post!!! Your question isn't weird or silly or anything negative!!!! It is the question of a concerned mom! It might be a very good idea for you to ask these questions of your Mito doc ... or ask for a referral to a geneticist. Since each Mito problem is specific to the patient .... it should be someone familiar with YOUR diagnosis who gives you the real answer! However ..... asking the question .... "Is my child's Mito caused by a problem with the Mitochondrial DNA or the Nuclear DNA?" is the place to start. Then ... if Nuclear ... ask whether the problem is "autosomal DOMINANT or RECESSIVE". Once you have those answers from the doctor .... go to the UMDF website (see above link explanation) and do some reading ... and then ask more questions if you need to! Jean mswims2007 wrote: This might seem like a weird question, but I have to ask it. If our kids have this disease and they grow up and get married and want to have children, will their children get this disease? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 8, 2004 Report Share Posted April 8, 2004 It depends upon the genetics involved in *your* kids' Mito! If it is Mitochondrial DNA that is the problem, then your daughters can pass it along to her sons and daughters, but your sons cannot .... this is because the tail of the sperm ( where the mitochondria are located so that spermie can do the swimming ) falls off and doesn't penetrate the egg ... so the male mitochondria don't imprint on the egg. This is called a "Maternal Inheritance" pattern. If it is Nuclear DNA that is your problem (the nucleus is the "boss" in the cell and if it has a problem, then it doesn't provide the mitochondria with the right materials to operate its factory properly) then both your sons and your daugters have the potential of passing along your brand of Mitochondrial Disease. Remember the Mendelian Inheritance in high school biology ... and the fruit flies? Well ... with Nuclear DNA inheritance you can have a number of combinations, depending upon whether your kind of Mito has a dominant genetic pattern or a recessive pattern. If you go to <http://umdf.org/> and then to "Information" and choose "For parents and families" you will be able to click on a page called "Genetics" .... and this page will explain it with diagrams, which I can't do on a post!!! Your question isn't weird or silly or anything negative!!!! It is the question of a concerned mom! It might be a very good idea for you to ask these questions of your Mito doc ... or ask for a referral to a geneticist. Since each Mito problem is specific to the patient .... it should be someone familiar with YOUR diagnosis who gives you the real answer! However ..... asking the question .... "Is my child's Mito caused by a problem with the Mitochondrial DNA or the Nuclear DNA?" is the place to start. Then ... if Nuclear ... ask whether the problem is "autosomal DOMINANT or RECESSIVE". Once you have those answers from the doctor .... go to the UMDF website (see above link explanation) and do some reading ... and then ask more questions if you need to! Jean mswims2007 wrote: This might seem like a weird question, but I have to ask it. If our kids have this disease and they grow up and get married and want to have children, will their children get this disease? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 9, 2004 Report Share Posted April 9, 2004 Thanks Jean, That was very helpful... As parents we have hopes and dreams for our kids and sometimes with this disease the future looks a little scary. However,I need to remind myself every day to live for the day and enjoy my boys as much as possible... Marie > > > This might seem like a weird question, but I have to ask it. If our > > kids have this disease and they grow up and get married and want to > > have children, will their children get this disease? > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 9, 2004 Report Share Posted April 9, 2004 Thanks Jean, That was very helpful... As parents we have hopes and dreams for our kids and sometimes with this disease the future looks a little scary. However,I need to remind myself every day to live for the day and enjoy my boys as much as possible... Marie > > > This might seem like a weird question, but I have to ask it. If our > > kids have this disease and they grow up and get married and want to > > have children, will their children get this disease? > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 9, 2004 Report Share Posted April 9, 2004 Thanks Jean, That was very helpful... As parents we have hopes and dreams for our kids and sometimes with this disease the future looks a little scary. However,I need to remind myself every day to live for the day and enjoy my boys as much as possible... Marie > > > This might seem like a weird question, but I have to ask it. If our > > kids have this disease and they grow up and get married and want to > > have children, will their children get this disease? > > > > Quote Link to comment Share on other sites More sharing options...
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