Re: FWD: Can't Keep Pounds Off? Hormone Is Clue (WebMD)

[Guest guest]

Yay! More, more -- Thanks for researching this.

Not that any of us could do anything about it right now if you uncoversome

miraculously

important clue . . . .but good results and good news could be heartening and

could offer

real hope. On the other hand, I also think you're not off track when you note

that there

are those waiting in the wings and hoping to sell leptin pills or shots and make

a, (if you'll

pardon the bad pun) killing!

--Annie

-- In South-Beach-Diet-Getting-It-Right , " Noctaire "

wrote:

>

> > I sure hope they're onto something here and that the results

> > are valid. It would be a very promising discovery that

> > could lead to some potential breakthroughs in obesity

> > treatments, one would think.

> > Though, I still think we all need to learn to eat properly,

> > regardless.

>

> Reading more about leptin suggests to me that it isn't as clear as this

> article suggests. Researchers have been looking at leptin and obesity for

> some time. What they've found is that there are increased amounts of leptin

> in those with increased amounts of adipose tissue (fat) and, conversely,

> there is less in those with less fat. There are clearly correlations

> between leptin levels and obesity but I wouldn't go out and buy leptin pills

> just yet (which is where I think this study is leading). Simply modifying

> leptin levels in the body isn't quite the answer.

>

> A 1998 study states, " THE HORMONE LEPTIN is thought to control satiety and

> adiposity by acting as a feedback signal between the adipocytes and the

> hypothalamus " . There's some discussion of " leptin resistance " . If we have

> leptin resistance, much like insulin resistance, then injections of leptin

> would help overcome that resistance. I would think that kind of treatment

> could also have the undesirable effect of creating/increasing resistance

> over time though.

>

> Maybe I'm overanalyzing this a bit, but I'm finding it fascinating what

> these researchers have observed.

>

> I'll be reading up on it some more this weekend.

>

>

>

[Guest guest]

Thanks for the research!

I'm involved in five other things at the moment, but it looks pretty good....

though I'm

always skeptical if a website bills itself as " top tier. " That sounds hokey to

me. So, I hope

i'm wrong.

I'll look at this more later.

Thanks.

>

> > Fascinating and potential so useful!

> > I see this reads like a press release, though.

>

> It's a review of a study in the Journal of

> Clinical Investigation, so it's sort of a press

> release.

>

> > What do you know about the Journal of Clinical

> > Investigation?

>

> I can tell you it is a real medical journal,

> published since 1924. On the journal's website

> it says " The JCI is a top-tier journal publishing

> biologically significant findings with clinical

> relevance " . This journal has had several

> articles on leptin - my search of the archives

> came up with 251 hits.

>

> http://www.jci.org/

>

> > And the WebMD site?

>

> Started by Dr. Koop, if I remember correctly; the

> former Surgeon General of the United States. One

> of the better and more reliable sources of

> medical info for the layperson.

>

> > Also, I wonder who the researcher are who did

> the study.

>

> Here's a link to the abstract for the actual

> study:

>

> http://www.jci.org/cgi/content/abstract/115/12/3579?

maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=leptin&searchid=113413289

3205_1306&stored_search=&FIRSTINDEX=0&journalcode=jci

>

> It shows that Dr. Rosenbaum, the lead

> investigator, is faculty at Columbia University

> College of Physicians and Surgeons in New York.

> You could try googling him and see if there is an

> on-line CV, or even looking at CU's website -

> they probably have a blurb about him.

>

> CindyB.

>

[Guest guest]

Hmmmnnn. Well . . . . I'm sure there are many who are waiting to see what

unfolds with

this!

> > >

> > > > Fascinating and potential so useful!

> > > > I see this reads like a press release,

> > though.

> > >

> > > It's a review of a study in the Journal of

> > > Clinical Investigation, so it's sort of a

> > press

> > > release.

> > >

> > > > What do you know about the Journal of

> > Clinical

> > > > Investigation?

> > >

> > > I can tell you it is a real medical journal,

> > > published since 1924. On the journal's

> > website

> > > it says " The JCI is a top-tier journal

> > publishing

> > > biologically significant findings with

> > clinical

> > > relevance " . This journal has had several

> > > articles on leptin - my search of the

> > archives

> > > came up with 251 hits.

> > >

> > > http://www.jci.org/

> > >

> > > > And the WebMD site?

> > >

> > > Started by Dr. Koop, if I remember correctly;

> > the

> > > former Surgeon General of the United States.

> > One

> > > of the better and more reliable sources of

> > > medical info for the layperson.

> > >

> > > > Also, I wonder who the researcher are who

> > did

> > > the study.

> > >

> > > Here's a link to the abstract for the actual

> > > study:

> > >

> > >

> >

> http://www.jci.org/cgi/content/abstract/115/12/3579?

> >

>

maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=leptin&searchid=113413289

> >

> 3205_1306&stored_search=&FIRSTINDEX=0&journalcode=jci

> > >

> > > It shows that Dr. Rosenbaum, the lead

> > > investigator, is faculty at Columbia

> > University

> > > College of Physicians and Surgeons in New

> > York.

> > > You could try googling him and see if there

> > is an

> > > on-line CV, or even looking at CU's website -

> > > they probably have a blurb about him.

> > >

> > > CindyB.

> > >

> >

> >

> >

> >

> >

>