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Ban on British Spleens

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Headline: BSE FEARS LEAD TO BAN ON BRITISH SPLEENS

Wire Service: PA (PA News)

Date: Mon, Nov 30, 1998

Copyright 1998 PA News. Copying, storing, redistribution, retransmission,

publication, transfer or commerical exploitation of this information is

expressly forbidden.

By von Radowitz, Medical Correspondent, PA News

Concern over the possibility that BSE-contaminated beef might infect the

spleen today led to a ban on using organs from British patients for a

diagnostic test.

Spleen tissue is used to test for a rare inflammatory disease,

sarcoidosis. Specially prepared spleen tissue from someone with the disease

is injected under the skin of the recipient patient to see if it produces a

reaction.

From now on, the Kveim Skin Test will have to rely on spleens taken from

donors from countries other than the UK that have a low BSE risk.

Announcing the move today, Health Secretary Dobson stressed it was

a purely precautionary measure.

He pointed out that the Kveim Skin Test was very rarely used. In the

past 12 years only two spleens had been used in the production of the test

tissue, called Kveim Skin Test Antigen (KSTA), in Britain.

Both donors were still alive and had no signs of neurological illness.

The spleen, a plum-coloured organ lying behind the stomach, produces

white blood cells and acts as an emergency reservoir of red blood cells.

Experts believe organs such as the spleen and lymph nodes may carry new

variant CJD -- the human version of BSE -- as well as the brain and spinal

cord.

The Government was advised to take action over the possible risk from

spleen tissue by the Spongiform Encephalopathy Advisory Committee, which

helps shape policy on BSE and CJD.

Mr Dobson said: " The Government has said it will take whatever steps

advised are necessary to protect the public from the risk of exposure to

nvCJD. Although there is no evidence of transmission via the Kveim Skin

Test it is right that we should act immediately on the advice of our

experts. "

Sarcoidosis, which most often appears in the lungs or lymph nodes, can

easily escape diagnosis or be mistaken for several other illnesses.

The Kveim Skin Test is one method used to diagnose sarcoidosis in a

minority of cases where it is considered clinically appropriate.

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