Guest guest Posted March 12, 2000 Report Share Posted March 12, 2000 Steph, Have you heard something about anti-IgE being used for food allergies in any other clinical trials? The reason why I ask is that at last year's FAN conference, Dr. Wood from s Hopkins explained all about Genentech's anti-IgE product but the clinical trials are currently on allergic rhinitis and allergic asthma only. He said that once the trials are completed, that the approval would be for these two conditions but that in the future, its applicability to food allergies is strong possibility since it shuts off all IgE response. Thanks for any info. I figure that the latest details will be presented at next Saturday's FAN conference in Crystal City. Lynda Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 12, 2000 Report Share Posted March 12, 2000 Lynda, As Kenny posted, one of the current trials is pinpointing peanut allergy. S. [eosinophilic gastroenteritis] re: Anti-IgE Steph, Have you heard something about anti-IgE being used for food allergies in any other clinical trials? The reason why I ask is that at last year's FAN conference, Dr. Wood from s Hopkins explained all about Genentech's anti-IgE product but the clinical trials are currently on allergic rhinitis and allergic asthma only. He said that once the trials are completed, that the approval would be for these two conditions but that in the future, its applicability to food allergies is strong possibility since it shuts off all IgE response. Thanks for any info. I figure that the latest details will be presented at next Saturday's FAN conference in Crystal City. Lynda Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 12, 2000 Report Share Posted March 12, 2000 I missed Kenny's post, but there are two anti-IgE studies going on. I think I have my facts straight. One is with Genentech, it is called rhuMAb-E25, and this is in Phase III clinical trials. You can find out the status of this by going to www.genentech.com and clicking on the icon for "product pipeline". The Genentech one is focused on allergic rhinitis and allergic asthma by shutting off *all* of the IgE mechanism in the body. The clinical trials for this one is being done at National Jewish. The Tanox one, Hu-901anti-IgE monoclonal antibody , found at www.tanox.com, which Dr. Sampson is involved withis anti-IgE is allergen specific for peanuts. In other words, he spent several years isolating the actual peanut protein that causes the IgE mediated allergic response, and then has been working at least for the last couple of years on designing an anti-IgE therapy specific to that particular protein. This is is Phase I/II clinical trials, according to information on the Tanox website. The way the Tanox anti-IgE will work for other foods is that the actual protein causing the allergic reaction will have to be isolated for each food. The impression I got at the last FAN conference was that the Genentech "one size fits all" type of Anti-IgE therapy holds greater promise for being available quicker to help food allergies other than peanuts. But, once Dr. Sampson's anti-IgE is perfected, the research on finding ones for other foods will go quicker than the intial one for peanuts. I have not been following all of the list discussion on this topic but thought I would offer what I know in case it is helpful. If anyone has any current updates about either of them, I would be most interested to know. Lynda (Matt, age 10, milk, soy, apples, coconut, yellow dye, erythromycin, demerol. Oak, ragweed, dustmites, cats. Anaphylactic reactions to milk and ragweed. Asthma, reflux. Thal fundoplication for reflux, repair of congenital diaphragmatic hernia) Quote Link to comment Share on other sites More sharing options...
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