Re: How long drugs work

[Guest guest]

<< I've read a lot about Sinemet not working for more than a few months

normally

so I never bothered trying it. My question is do Permax, Mirapex, or Requip

last any longer??!! Please let me know if you've had longer term success with

any of these. >>

I used Klonopin for about 2 years.....it " worked " (in that I could go to sleep

even if my RLS was " hurting " me) but the side-effects (e.g. hangover,

depressing, irritability, etc.) were terrible.

I have taken Permax for about 1 1/2 years with great success. My RLS still

acts up here and there but not as often nor as regularly. I did experience

some mild daytime symptoms around 12:00 noon when I " rested " for lunch. I

also had some arm RLS symptoms during the day but again, not too bad and more

of a minor nuisance. I was taking 0.15mg for a long time and I would

occasionally take .20mg. About 2-3 months ago, I bumped the dose to 0.25mg

(one pill instead of the usual 3-4 pills of the 0.005mg tabs) and I have no

problems with day time nor arm symptoms now. How long will it last? Who

knows! However, I am currently " pretty satisfied " with my current dose of

Permax and my 5-10mg of Ambien at bedtime. One more thing, I learned via

trial and error that I eventually had to change my Permax dose from around 1-2

hours before bedtime (8:00pm) to more like around 4:30 - 5:30 pm with better

results. And one more freaky episode that only happened once, I had a

terrible episode of RLS around 4-5:00 in the morning. Has not happened since.

I thought that 4:00 am was one of the few times that you count on RLS to be

quiet and be good to you. Oh well!

RAINBOWPED@...

[Guest guest]

Hi Bill and Group,

Mirapex has lasted longer for me, in relieving symptoms, and without the

rebound and augmentation of Sinemet, which was really bad after about 3

months. Mirapex is not a miracle drug - a side effect is insomnia, I

still have " attacks " , and daytime is a problem if I have to sit for any

length of time. Right now I am trying some alternative meds, and Jill's

techniques. This is like a war - we need to use any and all resources

available.

ne, 59, Lawrenceville, NJ

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