Guest guest Posted January 13, 1999 Report Share Posted January 13, 1999 To all: All of you who are taking Neurontin (gabapentin) can rest assured, regardless of what you have read on this net, that there is no danger of liver or kidney damage due to taking this drug. An extensive search of the literature reveals no cases of liver or kidney damage. In fact, several papers point to Neurontin as one of the safer drugs being used as an anticonvulsant. The reason for its safety is that Neurontin is not metabolized by the body. It is excreted in the urine as the intact drug. Mention is made that people with PRE-EXISTING kidney disease should adjust the dose of Neurontin because it can build up if not excreted in the urine at the expected rate. The same is true of Mirapex and many other drugs. The damage referred to is not done by the Neurontin, it was there before you started taking it. It is well recognized that Neurontin will increase the effect of any central nervous system depressant. It does this in epileptics (the FDA indication for Neurontin) as well as in people with RLS or anybody else. All of the benzodiazepines are CNS depressants as is alcohol and sleeping pills of any type. The way to handle this is to reduce the usual dose of benzodiazepine or other CNS depressant if you find that the effect is too strong because of the combined effect with Neurontin. The product information in the PDR (which is the approved FDA wording) states that routine lab studies are not needed when taking Neurontin. If someone has information that contradicts the above, I would appreciate the education. If not, I think that in fairness to the people taking Neurontin that this misinformation stop. Express your opinion all you want, but don't label it as fact. If the shoe fits..... Dr. Levin Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 13, 1999 Report Share Posted January 13, 1999 Thank you Dr. Levin for all of your wonderful information about treatments. I welcome the learning experience. I hope everyone is well. Deborah Quote Link to comment Share on other sites More sharing options...
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