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-Lyme and Spect abstracts:

Result 1.

Unique Identifier 9225802

Status MEDLINE

Authors Sumiya H. Kobayashi K. Mizukoshi C. Aoki T. Koshino Y. Taki J. Tonami N.

Authors Full Name Sumiya, H. Kobayashi, K. Mizukoshi, C. Aoki, T. Koshino, Y.

Taki, J.

Tonami, N.

Institution Department of Nuclear Medicine, Kanazawa University School of

Medicine,

Japan.

Title Brain perfusion SPECT in Lyme neuroborreliosis.

Source Journal of Nuclear Medicine. 38(7):1120-2, 1997 Jul.

Abstract SPECT imaging brain perfusion using 99mTc-HMPAO was performed on a

38-yr-

old women with Lyme neuroborreliosis confirmed by autopsy. The patient had been

suspected of spinocerebellar degeneration. Cerebral blood flow was diffusely

decreased

throughout cerebral cortices but cerebellar blood flow was not impaired, which

indicated

that the diagnosis was unlikely spinocerebellar degeneration. These findings

suggested

that brain perfusion SPECT provides useful information in diagnosing the

patients with

Lyme neuroborreliosis, especially when spinocerebellar degeneration is included

in the

differential diagnosis.

Publication Type Case Reports. Journal Article.

Result 2.

Unique Identifier 9082597

Status MEDLINE

Authors Logigian EL.

Authors Full Name Logigian, E L.

Title [Chronic neuroborreliosis in Lyme disease]. [Russian]

Source Terapevticheskii Arkhiv. 68(5):41-4, 1996.

Abstract Acute and chronic syndromes of Lyme neuroborreliosis are recognized.

Acute

syndromes are clinically pronounced and comprise meningitis, neuritis of the

cranial

nerve, radiculoneuritis. Chronic syndromes are less evident. These are moderate

encephalopathy and radiculoneuropathy. The diagnosis of the chronic syndrome is

based

on the presence of early classic signs of BL. CSF must be tested for routine

procedure and

in pair with serum in the test for selective accumulation of antibodies to Bb in

the CSF.

Neurophysiological studies help detect memory defects. Electrophysiological

tests verify

radiculoneuropathy. NMR investigation of the brain and SPECT-scanning may

demonstrate

damage to the white brain matter. We have much experience with i.v.

administration of

ceftriaxone (2 g/day for 4 weeks) which relieved neurological syndromes several

months

later.

Publication Type Case Reports. English Abstract. Journal Article.

Result 3.

Unique Identifier 7610672

Status MEDLINE

Authors Zifko U. Schmidt B. Grisold W. Stanek G.

Authors Full Name Zifko, U. Schmidt, B. Grisold, W. Stanek, G.

Institution Neurologischen Abteilung, Kaiser-Franz-f-Spitals, Wien.

Title [Neurosyphilis. A case report and review of the literature on differential

neuroborreliosis diagnosis]. [Review] [27 refs] [German]

Source Wiener Medizinische Wochenschrift. 145(7-8):191-4, 1995.

Abstract A 35-year old man was presented with organic psychosyndrome. Anamnestic

reports informed about changes in his behaviour like loss of interest, reduced

concentration and short-term-memory loss within the last 2 years. The practicing

psychiatrist diagnosed a depressive syndrome in conjunction with a borderline

syndrome

and administered antidepressive and neuroleptic therapy. Specific serologic

tests were not

done. Neurologically, there was a picture of influent and slurred speech, and

ataxic gait.

Muscle tonus was normal, muscle reflexes were of the same diminished intensity

on both

sides. The psychic status revealed a person mostly oriented in time, location

and situation

but with severe disorders of recognition, concentration, and memory. Laboratory

diagnosis proved the suspected diagnosis of neurosyphilis. Additionally, there

were

antibodies to Borrelia burgdorferi (Bb) in serum and CSF and a positive

CSF/serum index of

9.0 (threshold: 1.9). The neuroradiologic examination (CCT, NMR, SPECT) showed

an

intense, diffuse, frontotemporal atrophy of the cortex. By NMR, massive gliosis

was found

in both hippocampi. Angiographically, an aneurysma (1 cm in diameter) of the

medial

cerebral artery was demonstrated. Specific treatment was performed with Na

penicillin (5

Mio. i.v./4 h over 21 days). No remission could be achieved. [References: 27]

Publication Type Case Reports. English Abstract. Journal Article. Review.

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