Guest guest Posted January 27, 1999 Report Share Posted January 27, 1999 Hi gang, Many of you asked to be kept posted regarding the research study at Emory. Well, here's an update: I can't get through to a real person!! I have left numerous voice mails but haven't been called back. So I'm a tad bit frustrated right now. Regarding Klonopin and memory loss, thanks for all the suggestions on how to possibly deal with this situation. I need to compile a list and evaluate the whole thing, if I can remember to do it! Just kidding - I'm not that bad, at least on good days. Several of you suggested I stop taking the Klonopin, but I feel very torn about that idea. I can either keep on the med and at least sleep 5 hours or so, thus keeping my back from acting up. Or I can quit Klonopin, hopefully have better memory function, yet take the chance of having my muscle spasms start back (happens whenever I don't adequately rest my back). I just don't know. Anyway, thanks for all the response I've gotten and I will continue to keep you posted if anything develops with this study. Meanwhile, try to have sweet dreams! , Atlanta, 34 the city that has everyone doing the " dirty bird " GO FALCONS Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 14, 2009 Report Share Posted March 14, 2009 Desr ; I am curious if Drs. Bowlus and Gershwin will be looking at the balance between Th17 and Treg cells in this study? There is growing evidence that this (im)balance is important in IBD and PBC; see for example: __________________________________ Clinical & Experimental Immunology Published Online: 4 Feb 2009 Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: the serum cytokine profile and peripheral cell population. G. Rong,* § Y. Zhou,* § Y. Xiong,* L. Zhou,* H. Geng,* T. Jiang,* Y. Zhu,* H. Lu,* S. Zhang,* P. Wang, † B. Zhang ‡ and R. Zhong* *Department of Laboratory Medicine, Changzheng Hospital, and Departments of † Gastroenterology, and ‡ General Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China Correspondence to R. Zhong, Department of Laboratory Medicine, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China. E-mail: rqzhong@... § Guanghua Rong and Yunheng Zhou contributed equally to this work. KEYWORDS autoimmunity • PBC • Th17 cells • Treg cells ABSTRACT Primary biliary cirrhosis (PBC) is an organ-specific autoimmune liver disease characterized by progressive loss of intrahepatic small bile ducts. Cellular immune mechanisms involving T cell reaction are thought to be involved significantly in the pathogenesis of PBC. Recent studies have independently revealed enhanced T helper type 17 (Th17) response and weakened T regulatory cell (Treg) response in some autoimmune diseases, indicating a role of Th17/Treg imbalance in the pathogenesis of autoimmunity. This prompted us to investigate whether the Th17/Treg balance was broken in the peripheral blood of patients with PBC and, if it was, what cytokine circumstances might contribute to this imbalance. The expression of 11 Th17/Treg differentiation-related genes and serum concentrations of the corresponding cytokines in 36 patients with PBC, 28 patients with chronic hepatitis B and 28 healthy controls were measured by real-time quantitative-polymerase chain reaction and enzyme-linked immunosorbent assay respectively. Peripheral Th17 and Treg cells were analysed by flow cytometry. Th17-related cytokines were increased significantly in patients with PBC. Consistent with the cytokine profile, the Th17 cell population and retinoid-related orphan receptor gammat expression were increased markedly. In contrast, the Treg cell population and forkhead box P3 expression were decreased dramatically in the peripheral blood of patients with PBC. Our study revealed that the Th17/Treg imbalance, both cytokine profile and cell numbers, exists in patients with PBC, suggesting its potential role in the breakdown of immune self-tolerance in PBC. Interleukin-23, which characterized the imbalanced cytokine profile, may play an essential role in Th17-related human autoimmunity. __________________________________ So it would seem reasonble to look to see if this balance is also disturbed in PSC. I couldn't tell from your post what receptor they are looking for, and in which type of T cell. Best regards, Dave (father of (23); PSC 07/03; UC 08/03) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 14, 2009 Report Share Posted March 14, 2009 Desr ; I am curious if Drs. Bowlus and Gershwin will be looking at the balance between Th17 and Treg cells in this study? There is growing evidence that this (im)balance is important in IBD and PBC; see for example: __________________________________ Clinical & Experimental Immunology Published Online: 4 Feb 2009 Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: the serum cytokine profile and peripheral cell population. G. Rong,* § Y. Zhou,* § Y. Xiong,* L. Zhou,* H. Geng,* T. Jiang,* Y. Zhu,* H. Lu,* S. Zhang,* P. Wang, † B. Zhang ‡ and R. Zhong* *Department of Laboratory Medicine, Changzheng Hospital, and Departments of † Gastroenterology, and ‡ General Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China Correspondence to R. Zhong, Department of Laboratory Medicine, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China. E-mail: rqzhong@... § Guanghua Rong and Yunheng Zhou contributed equally to this work. KEYWORDS autoimmunity • PBC • Th17 cells • Treg cells ABSTRACT Primary biliary cirrhosis (PBC) is an organ-specific autoimmune liver disease characterized by progressive loss of intrahepatic small bile ducts. Cellular immune mechanisms involving T cell reaction are thought to be involved significantly in the pathogenesis of PBC. Recent studies have independently revealed enhanced T helper type 17 (Th17) response and weakened T regulatory cell (Treg) response in some autoimmune diseases, indicating a role of Th17/Treg imbalance in the pathogenesis of autoimmunity. This prompted us to investigate whether the Th17/Treg balance was broken in the peripheral blood of patients with PBC and, if it was, what cytokine circumstances might contribute to this imbalance. The expression of 11 Th17/Treg differentiation-related genes and serum concentrations of the corresponding cytokines in 36 patients with PBC, 28 patients with chronic hepatitis B and 28 healthy controls were measured by real-time quantitative-polymerase chain reaction and enzyme-linked immunosorbent assay respectively. Peripheral Th17 and Treg cells were analysed by flow cytometry. Th17-related cytokines were increased significantly in patients with PBC. Consistent with the cytokine profile, the Th17 cell population and retinoid-related orphan receptor gammat expression were increased markedly. In contrast, the Treg cell population and forkhead box P3 expression were decreased dramatically in the peripheral blood of patients with PBC. Our study revealed that the Th17/Treg imbalance, both cytokine profile and cell numbers, exists in patients with PBC, suggesting its potential role in the breakdown of immune self-tolerance in PBC. Interleukin-23, which characterized the imbalanced cytokine profile, may play an essential role in Th17-related human autoimmunity. __________________________________ So it would seem reasonble to look to see if this balance is also disturbed in PSC. I couldn't tell from your post what receptor they are looking for, and in which type of T cell. Best regards, Dave (father of (23); PSC 07/03; UC 08/03) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 14, 2009 Report Share Posted March 14, 2009 Desr ; I am curious if Drs. Bowlus and Gershwin will be looking at the balance between Th17 and Treg cells in this study? There is growing evidence that this (im)balance is important in IBD and PBC; see for example: __________________________________ Clinical & Experimental Immunology Published Online: 4 Feb 2009 Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: the serum cytokine profile and peripheral cell population. G. Rong,* § Y. Zhou,* § Y. Xiong,* L. Zhou,* H. Geng,* T. Jiang,* Y. Zhu,* H. Lu,* S. Zhang,* P. Wang, † B. Zhang ‡ and R. Zhong* *Department of Laboratory Medicine, Changzheng Hospital, and Departments of † Gastroenterology, and ‡ General Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China Correspondence to R. Zhong, Department of Laboratory Medicine, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China. E-mail: rqzhong@... § Guanghua Rong and Yunheng Zhou contributed equally to this work. KEYWORDS autoimmunity • PBC • Th17 cells • Treg cells ABSTRACT Primary biliary cirrhosis (PBC) is an organ-specific autoimmune liver disease characterized by progressive loss of intrahepatic small bile ducts. Cellular immune mechanisms involving T cell reaction are thought to be involved significantly in the pathogenesis of PBC. Recent studies have independently revealed enhanced T helper type 17 (Th17) response and weakened T regulatory cell (Treg) response in some autoimmune diseases, indicating a role of Th17/Treg imbalance in the pathogenesis of autoimmunity. This prompted us to investigate whether the Th17/Treg balance was broken in the peripheral blood of patients with PBC and, if it was, what cytokine circumstances might contribute to this imbalance. The expression of 11 Th17/Treg differentiation-related genes and serum concentrations of the corresponding cytokines in 36 patients with PBC, 28 patients with chronic hepatitis B and 28 healthy controls were measured by real-time quantitative-polymerase chain reaction and enzyme-linked immunosorbent assay respectively. Peripheral Th17 and Treg cells were analysed by flow cytometry. Th17-related cytokines were increased significantly in patients with PBC. Consistent with the cytokine profile, the Th17 cell population and retinoid-related orphan receptor gammat expression were increased markedly. In contrast, the Treg cell population and forkhead box P3 expression were decreased dramatically in the peripheral blood of patients with PBC. Our study revealed that the Th17/Treg imbalance, both cytokine profile and cell numbers, exists in patients with PBC, suggesting its potential role in the breakdown of immune self-tolerance in PBC. Interleukin-23, which characterized the imbalanced cytokine profile, may play an essential role in Th17-related human autoimmunity. __________________________________ So it would seem reasonble to look to see if this balance is also disturbed in PSC. I couldn't tell from your post what receptor they are looking for, and in which type of T cell. Best regards, Dave (father of (23); PSC 07/03; UC 08/03) Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.