Guest guest Posted March 9, 2000 Report Share Posted March 9, 2000 Hi Jim, Amitriptyline is a 'neuro-transmitter' affecting the serotonin levels in the brain. Anytime 'neuro-transmitter' medications are used, the 'natural' chemicals in the brain are changed. This takes some time. While I DID notice a remarkable difference after only 4 days, the real difference was 6 months later. Amitriptyline is slower to work/and build up to. And that " drugged " feeling mornings went away about 7-10 days after I started taking it. First I started with 50 mg, then up to 75, then to 100, and back down, 75, 50, then 25 mg was a good maintenance dose. Gretchen Quote Link to comment Share on other sites More sharing options...
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