GFCF,SCD and dairy/ the latest scientific research

November 10, 2005

The latest scientific research reveals that both both SCD and GFCF

are right about their position regarding dairy. I will try to

explain this contradiction. There is no contradiction, it is the

bacteria in the GI system that are causing the milk intolearnce.

When we remove the bacteria with SCD,the milk intolerance might

disappears.

A very important research paper about autism and diet was written by

Jyonouchi and was published by Neuropsychobiology.

The Jyonouchi research article says that :

" Children with autism spectrum disorder (ASD) frequently reveal

various gastrointestinal (GI) symptoms that may resolve with an

elimination diet along with apparent improvement of some of the

behavioral symptoms "

The eliminated foods were: " gliadin, cow's milk protein

(CMP),soy... "

So it is obvious that Jyonouchi says that the GFCF diet is right

about its ban on cow dairy.

However, the Jyonouchi article also vindicates SCD. It says that

this intolerance to cow dairy is caused by endotoxin, a product of

the gut bacteria.

Our list recommends that ASD children wait for some time before

starting GOAT yogurt.This gives them time to get rid of the

endotoxin.

(A big percentage of our children cannot tolerate cow yogurt. We

even need to have a starter made with goat milk for our goat

yogurt.)

More information about this research article is under my post. If

anyone asks,I will post more research articles that show that food

intolerances disappear after the bacteria in the GI system are

eliminated

Mimi

Jyonouchi's Paper

Neuropsychobiology. 2002;46(2):76-84.

Elaine Gottschall's Comments on Jyonouchi's Paper

The abstract of Jyonouchi's paper says Children with autism

spectrum disorder (ASD) frequently reveal various gastrointestinal

(GI) symptoms that may resolve with an elimination diet along with

apparent improvement of some of the behavorial symptoms. Evidence

suggests that ASD may be accompanied by aberrant (inflammatory)

innate immune responses. THIS MAY PREDISPOSE ASD CHILDREN TO

SENSITIVIES TO COMMON DIETARY PROTEINS LEADING TO GI INFLAMMATION

AND AGGRAVATION OF SOME BEHAVIORAL SYMPTOMS.

The authors demonstrate conclusively that there is an abnormal

immune response to cow's milk protein and wheat protein (gliadin)

and soy in ASD. What is interesting is that the diet model is NOT

THE SAME AS THE OPIOID MODEL BUT IS BASED ON A VARIABLE IMMUNE

RESPONSE IN WHICH NOT EVERY CHILD WILL SHOW SENSITIVITY TO EVERY

FOOD.

But the punch line is: The authors suggest that the root cause of

the food protein sensitivity may be an underlying sensitivity to

endotoxin or lipopolysaccharides (LPS) which comes from the surfaces

of gram negative bacteria in the gut.

This summarized means that this response to the bacterial endotoxin

(LPS) PREDISPOSE THESE CHILDREN TO SENSITIZATION TO DIETARY

PROTEINS. This is consistent with a model of abnormal gut flora

development that promotes immune response to gut bacteria. This

means that ASD kids may develop a kind of autoimmunie response to

their own gut flora.

Neuropsychobiology. 2002;46(2):76-84

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1\

2378124&dopt=Abstract

Innate immunity associated with inflammatory responses and cytokine

production against common dietary proteins in patients with autism

spectrum disorder.

Jyonouchi H, Sun S, Itokazu N.

Department of Pediatrics, University of Minnesota, Minneapolis,

Minn, USA.

OBJECTIVES: Children with autism spectrum disorder (ASD) frequently

reveal various gastrointestinal (GI) symptoms that may resolve with

an elimination diet along with apparent improvement of some of the

behavioral symptoms. Evidence suggests that ASD may be accompanied

by aberrant (inflammatory) innate immune responses. This may

predispose ASD children to sensitization to common dietary proteins

(DP), leading to GI inflammation and aggravation of some behavioral

symptoms. METHODS: We measured IFN-gamma, IL-5, and TNF-alpha

production against representative DPs [gliadin, cow's milk protein

(CMP), and soy] by peripheral blood mononuclear cells (PBMCs) from

ASD and control children [those with DP intolerance (DPI), ASD

siblings, and healthy unrelated children]. We evaluated the results

in association with proinflammatory and counter-regulatory cytokine

production with endotoxin (LPS), a microbial product of intestinal

flora and a surrogate stimulant for innate immune responses.

RESULTS: ASD PBMCs produced elevated IFN-gamma and TNF-alpha, but

not IL-5 with common DPs at high frequency as observed in DPI PBMCs.

ASD PBMCs revealed increased proinflammatory cytokine responses

with LPS at high frequency with positive correlation between

proinflammatory cytokine production with LPS and IFN-gamma and

TNF-alpha production against DPs. Such correlation was less evident

in DPI PBMCs. CONCLUSION: Immune reactivity to DPs may be associated

with apparent DPI and GI inflammation in ASD children that may be

partly associated with aberrant innate immune response against

AG, Basel

PMID: 12378124 [PubMed - indexed for MEDLINE]