Diagnostic approaches to sulfate testing

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I hope this is not too confusing to most of you, but some of you ladies will find this very interesting regarding sulfate approaches in heavy metal toxicity. Andy Cutler helps families with autistic children, who are many times heavy metal toxic from vaccinations.Re: Diagnostic approaches to sulphate testing

Q: When physicians order plasma sulfate and urinary sulfate testing for

these kids, how do they interpret the results and turn around and tell

us, the parents, what to do.

A: Well, I will give a theoretical answer since very few of them have a

clue - I have seen enough tests that are clear on this or that where

the physician made the opposite of the appropriate recommendation.

The interpretation depends on the following TWO results:

Plasma cysteine, and plasma sulfate.

The possible combinations are:

1. Cys low SO4 low

2. Cys normal SO4 low

3. Cys elevated SO4 low

4. Cys low SO4 normal

5. Cys normal SO4 normal

6. Cys elevated SO4 normal

7. Cys low SO4 elevated

8. Cys normal SO4 elevated

9. Cys elevated SO4 elevated

In cases 2, 3 and 6, there may be impaired conversion to sulfate and

molybdenum should be given.

In cases 3, 6 and 9 thiols and their precursors should be excluded

from the diet and supplements.

In cases 1, 4 and 7 thiols and their precursors should be maximized in

the diet and supplements IF and ONLY if the patient shows obvious

improvement with doing this.

In cases 1, 2 and 3 sulfate should be supplemented orally,

transdermally and by epsom salt bath.

In cases 7,8 and 9 sulfate is not being used and rigorous dietary

exclusion of things requiring sulfation is required.

In cases 1, 2 and 3 the pool of available sulfate is inadequate and

dietary restriction of things requiring sulfation may be helpful.

In case 4 it is possible (but not certain) that sulfate is not being

used well and dietary exclusion of things requiring sulfation will

help.

In cases 2, 5 and 8 it is not appropriate to try to create more

sulfate by feeding the patient precursors like cysteine, msm or whey.

Thiol intake must be moderate, neither excessive nor low. Sulfate

needs to go in as sulfate. This applies in spades to cases 3, 6 and

9.

In all cases, how the person responds to these interventions is a more

accurate guide to appropriate treatment than are numbers on a piece of

paper that comes from a laboratory.

>

> I do know its important to see whats in the urine as well as what is

in the blood to determine the whole picture.

>

> What does it tell us when our child's Plasma Sulfate levels are

High, Normal, and Low?

High = not using it. Very bad. Treatment is exclusion, not

supplementation. Supplementation is of no utility for this.

Normal may = evertyhing is fine, may = not using much AND not making

enough. In practice it means look at other things and revisit this

issue if nothing else is abnormal.

Low = sulfate depleted, it isn't there to use when needed. Do anything

and everything to increase sulfate levels. both supplementation and

dietary exclusion help here.

>

> Do high levels in the blood, and low levels in the urine mean

> kidney dysfunction?

It can mean many things, but by far the most likely is that the phase

2 sulfation reaction is slow, so that the sulfate isn't used and thus

builds up in blood. It is my impression that total sulfate, not free

sulfate, is what is measured in urine, so the urine sulfate level is

an indication of what amount of sulfated metabolite has been excreted

rather than an indication of the amount of free sulfate available in

the blood.

It is extremely difficult to imagine a kidney problem that would lead

to this without having other more dramatic signs on standard lab

tests.

> Do low levels in both blood and urine just mean that they need to

add more sulphury foods to the diet?

No, this is never appropriate under any circumstances. This is not

the way to increase sulfate. When you want more sulfate, give more

sulfate. Decide what to do with thiols depending on cysteine level.

>

> Has anyone tried glucosamine sulfate for low blood level of sulfate?

I vaguely recall some discussion of this. This does make a reasonable

amount of sense.

> I know that epsom salts baths are good for this as well.

>

> What can be done for children whose blood levels come back high?

> Is it a concern?

It is a major concern. Ignore sulfate itself (it is OK if that is

high), pay attention to the fact that they can't excrete things that

require sulfation and need some Feingold diet like intevention, as

well as the fact that they may not be able to make sulfated

biomolecules such as are needed for proper mucus membrane, cartilage,

etc. function.

> How do the results of the plasma cysteine test play into

> all of this.

In cases where cysteine is low and sulfate is low, or cysteine is high

and sulfate is high, there is some ambiguity as to what is going on.

In cases where cysteine is much higher than sulfate, there is an

apparent failure of the molybdenum enzyme sulfite oxidase to function

and this may be improved with molybdenum supplementation. Molybdenum

is also useful for other enzymes so this is a marker as well as a

direct indication.