immunopathology of siliconosis

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http://www.springerlink.com/content/8r8v7q5l5235486t/

The immunopathology of siliconosis

History, clinical presentation, and relation to silicosis and the

chemistry of silicon and silicone

Journal Immunologic Research

Publisher Humana Press Inc.

ISSN 0257-277X (Print) 1559-0755 (Online)

Issue Volume 18, Number 3 / December, 1998

DOI 10.1007/BF02788777

Pages 125-173

Subject Collection Medicine

SpringerLink Date Sunday, December 23, 2007

R. Shanklin1, 2 and L. Smalley1, 3

(1) Department of Pathology, University of Tennessee, 899 Madison Avenue M576, 38163 Memphis, TN

(2) Department of Obstetrics and Gynecology, University of Tennessee, Memphis, TN

(3) Baptist Regional Laboratories, Memphis, TN

Abstract

Recent evidence confirms the fundamental involvement of the human immune system in the reaction to implantation of silicone based medical devices.

An as yet-to-be particularized epitope of many complex substances sharing

siloxane structures is presented through the MHC-IIapparatus with development

and retention of T cell memory. This memory can be tested for in practical terms using one or more forms of silica, which links the immunohistopathology and autoimmune attributes of“silicosis†with those of “siliconosis.â€

The lesions of siliconosis are typical of those for persistent antigens and delayed, cell mediated hypersensitivity. The basic descriptive pathology of the reaction to silicone has been known since soon after introduction of silicones in medical procedures, with the exception of some details related to the more recent

discoveries on the role of cytokines in the immunopathic process. The clinical consequences of siliconosis are common and can be severe in some individuals implanted with silicone devices.

( All breast implants are silicone )

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