Product Desription

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DESCRIPTION

A deep brown liquid with a characteristic iodine odour and a dill flavour.

ACTIVE INGREDIENT

Povidin Sore Throat Gargle contains povidone-iodine 7.5% (equivalent

to 0.75% of available iodine) in an aqueous solution.

ACTIONS

Povidone-iodine is a loose complex of elemental iodine with a

neutral, amphipathic organic compound, polyvinylpyrrolidone, which

serves as a sustained release reservoir of iodine. The carrier

augments dispersibility and penetrance. Povidone-iodine is a topical

microbial antiseptic which essentially retains the broad-spectrum

activity of iodine, yet is virtually free from the undesirable

features associated with tincture of iodine and lugol's solution.

Iodine is bactericidal, sporicidal, fungicidal, protozoacidal,

cysticidal, and virucidal; gram-positive and gram-negative bacteria

are about equally affected.

INDICATIONS

Treatment and adjunctive therapy of viral pharyngitis.

ADVERSE EFFECTS

Local irritation and sensitivity may occur following topical

administration of povidone-iodine. In the event of swallowing a large

amount of povidone-iodine, systemic effects including metabolic

acidosis, hypernatraemis, and renal impairment may occur.

CONTRAINDICATIONS

Povidone-iodine should not be used on patients with non-toxic nodular

colloid goitre. Know hypersensitivity to povidone-iodine or any

component in the formulations.

PRECAUTIONS

In the very rare instance of local irritation or sensitivity,

discontinue use. Absorption of povidone-iodine may interfere with

tests of thyroid function. Povidin Sore Throat Gargle should not be

used over a prolonged period. If symptoms persists consult your

doctor or pharmacist.

RECOMMENDED DOSAGE

Dilute 1:20 using water (approximately 20 drops of Povidin Sore

Throat Gargie with 4 teaspoonful of water). Gargle for at least 15

seconds and repeat. Patients should gargle for at least four times a

day.

PACKING

Plastic bottles of 10ml and 1L.

REGISTRATION NO.

PBKD/91 1471X

STORAGE

Keep container well closed in a cool dry place and protect from

strong light. Keep out of the reach of children. Shelf-life : 2 years.

>Prevention of Respiratory Infections by Povidone-Iodine Gargle --

>Dermatology

>href=http://www.pulmonologylinx.com/thearts.cfm?artid=350566&specid=14http://www.pulmonologylinx.com/thearts.cfm?artid=350566&specid=14

>Conclusion: Results of this study suggest that povidone-iodine gargle is

>effective in providing a significant reduction in the incidence of acute

>exacerbations of chronic respiratory disease...

>

>

>Vol. 204, Suppl. 1, 2002 : Fourth Asian Pacific Congress on Antisepsis.

>Proceedings. Vancouver, Canada, July 18-20, 2001. Editors: H. Kobayashi,

>Tokyo; M. Ermini, Basel

>

>Oro-Buccal Antisepsis

>Prevention of Respiratory Infections by Povidone-Iodine Gargle

>Tsuyoshi Nagatake, Kamrudolin Ahmed, Kazunori Oishi

>Department of Internal Medicine, Institute of Tropical Medicine,

>Nagasaki University, Nagasaki, Japan

>Dermatology 204:S1:2002, 32-36.

>Abstract

>Bacterial attachment to host cells is the initial step in the

>pathogenesis of infection. Our studies and those of others also showed

>that there is a significant correlation between the attachment of

>bacteria to human pharyngeal epithelial cells and the occurrence of

>respiratory tract infections. We identified the receptor on human

>pharyngeal epithelial cells which mediate binding of Moraxella

>catarrhalis and Haemophilus influenzae. In an attempt to prevent

>occurrence of infections, the effects of povidone-iodine gargling on the

>incidence of respiratory infections were investigated. The subjects

>included a total of 23 adult patients, both males and females, with

>chronic respiratory diseases showing repeated infections. Patients were

>asked to gargle more than 4 times/day with povidone-iodine gargle over

>extended periods of time, i.e. from several months up to over 2 years.

>The incidence of episodes of acute exacerbation of chronic respiratory

>infections decreased significantly when compared with that before use of

>povidone-iodine gargle. Episodes of infections with Pseudomonas

>aeruginosa, Staphylococcus aureus (including MRSA) and H. influenzae

>were reduced by about 50%. Results of this study suggest that

>povidone-iodine gargle is effective in providing a significant reduction

>in the incidence of acute exacerbations of chronic respiratory disease.

>We assume that the colonized bacteria were destroyed and thus infection

>could not occur. Therefore, povidone-iodine gargle may be used in these

>patients as a preventive therapy. Further studies are needed to find out

>the mechanism of action of this drug for the prevention of respiratory

>tract infections.

Becki

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