Guest guest Posted September 6, 2003 Report Share Posted September 6, 2003 Dear , Thanks so much-- I really appreciate it and I am sure other moms who are working in this process do too. My daughter has IgA deficiency and suspected antibody deficiency so there will be probably some of the same issues that we are dealing with. In addition, my daughter has had 3 open heart surgeries 2 bouts of endocarditis and GERD, constipation and an undiagnosed vascular condition. Since she has a mechanical aortic valve and requires blood thinning medication--something so simple as a teacher throwing a soccer ball in the classroom as a get to know you game makes her very anxious as she is aware that she needs to avoid impact to her chest as well as in general to avoid internal bleeding. The communication barriers are enormous. We haven't been able to " talk " to anyone in administration for the three days my daughter has tried to attend school. I am thinking of having my doctor write a note so that I can accompany my daughter to school for a day and sit in on her classes with her to try and facilitate communication. I was wondering if anyone had done that? --Martha Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 6, 2003 Report Share Posted September 6, 2003 In a message dated 9/6/2003 12:26:45 PM Eastern Daylight Time, Bejenski@... writes: I'm sorry to make such a long letter, but I feel like I'm about to explode! Thank you. Lynne (mom to Sis: Igg def, subclasses low, severe asthma, reflux. : severe asthma, reflux) Lynne, my heart goes out to you. What does your IEP say? If it doesn't say anything about the school providing for the rest of her teaching day it certainly should. It is the school's job to teach your child, even if they are only there a half a day. It is up to the school to provide you with whatever necessary to accomplish that, even if it means that the teacher comes to your home again. And they can't put her in a special education classroom without your consent, your knowledge, and definitely not without an IEP on file stating that! I would certainly make an appointment with the principal to sit down and go over all that is happening, list your complaints, and document them. I hear this all the time, document, document, document. I would formally ask for a new IEP to be made, and make sure that every single thing is listed in there! I'd also request the superintendent be there at the meeting as well, and I'd consider filing a formal complaint against that teacher. A teacher with that attitude should not be teaching!!!! There are advocacy people out there that can give you excellent advice with knowledge of your particular school district, and contacting them for starting advice on how to handle this situation is a great first step. Diane, Mom to Kody, age 7, precious and precocious who has Di Syndrome, Hypogammaglobulinemia, epilepsy, asthma, chronic encopresis, and severe cognitive regression. Also Mom to Arika age 16, Kaila, age 12, and Sami age 9 (she happens to also be Dyslexic), and wife/soulmate to for 10 years. check out my website: www.geocities.com/schmidtzoo/SNAK Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 6, 2003 Report Share Posted September 6, 2003 Hi Lynn, I just read your post, that is ridiculous that you are having to go through all this.( Sis too). Do you mind my asking what state you live in? It comes to my mind there is a law? an Act? about No Child being left behind. I also believe you need an IEP( Individual Education Plan ) for Sis. We have a 504 plan for for some accommodations in the school, the IEP is the bigger gun. I just had our lawyer( my mom) rewrite her 504, she said it was too vague, it will be interesting what the school says( I don't think they can really say anything). I'm going through my conference stuff now to try and see what was said about school issues, if I find anything I'll get back to you. If you want I can ask my Mom( the lawyer, she does institutional law) if she has any suggestions. I hope things settle down for you all. MOM to Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 6, 2003 Report Share Posted September 6, 2003 Hi Martha, I have left a message with my Mom, I'll find out what I can, I'm sure she'll help, she went to the conference with us and finally now knows what we are all up against. I'll write back as soon as I hear. Mom to Re: re: Sis Hi , We are also trying to develop a 504 plan for who is now out of school because she is having allergic symptoms to something in the school at this time. Does your mom know of any resource books that we could use (or that she used) to develop a plan. All the information seems to be on IEP's and that is what I am now reading, but I know that the 504 is a civil rights law and may need to be worded differently? We have an ed consultant but she is not used to handling 504s. She has mainly dealt with IEP's --Martha Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 6, 2003 Report Share Posted September 6, 2003 from Dale, Mom to Katy, CVID, age 19 Sorry, I've never dealt with this because we homeschooled. So, all I can offer is my heartfelt sympathy to all of you struggling with this. Lynne, I'm so sorry. Schools shouldn't be this way -- but many are. I've listed some " Help " sites that may help, I don't know. National Information Center for Handicapped Children and Youth (www.nichcy.org) Telephone (800)695-0285 This organization is a national information and referral cneter that provides information on disabilities and disability-related issues for family, educators, and other professionals. Specific information on early intervention programs, special education, individualized education programs, education rights and transition to adult life can be found through this organization. Family Voices: www.familyvoices.org Telephone: 505-867-2368 A national organization that provides information and education concerning the health care of children with special health needs. Patient Advocate Foundation: www.patientadvocate.org Telephone: 800-532-5274 A national non-profit organization that serves as an active liaison between the patient and their insurer, employer, and/or creditors to resolve insurance, job discrimination and/or debt crisis matters relative to their diagnosis through case managers, doctors and attorneys. slaw: www.wrightslaw.com This web site is dedicated to helping individuals advocate for children with disabilities with regard to the education system and legal issues. Hope that helps, In His service, Dale Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 6, 2003 Report Share Posted September 6, 2003 Martha, I just received the 504 from my Mom, if anyone is interested I can type it in so they can see it. I don't mind. has Selective IgA deficiency so it may be different than what some of you may need but you can get some ideas, any specific questions just ask and I'll pass it on to Mom. Just let me know, I'll be on ans off today, we are actually home for a change. Original Message ----- From: K979@... Sent: Saturday, September 06, 2003 4:06 PM Subject: Re: re: Sis Dear , Thanks so much. I was even wondering if a bunch of us should collaborate and try to write a sample PID 504 plan for the PID website once we are done. I noticed that the diabetes organization have a sample 504 plan that can be tailored to an individual's needs which they have posted on their website. --Martha Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 6, 2003 Report Share Posted September 6, 2003 : I'd love to see your 504 plan. I'm already nervous about this aspect of school and doesn't start K until NEXT fall!!! Thanks -- (mom to Kate, born 9/19/02, dairy intolerant; and , age 4-1/2, GERD, dairy intolerant -- currently has polysaccharide antibody def, previously had transient IgG, IgA, t-cell & other defs) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 6, 2003 Report Share Posted September 6, 2003 In a message dated 9/6/2003 3:51:58 PM Central Standard Time, SNAKpackmomma@... writes: > I > would certainly make an appointment with the principal to sit down and go > over > all that is happening, list your complaints, and document them. I hear this > all the time, document, document, document. I would formally ask for a new > IEP > to be made, and make sure that every single thing is listed in there! I'd > also > request the superintendent be there at the meeting as well, and I'd consider > filing a formal complaint against that teacher. Oh, I agree. And make sure you're very calm and rational and professional, don't let them think you're a hysterical mother. Treat it like a business meeting, don't get too emotional or they won't take you as seriously. Good luck! (mom to Kate, born 9/19/02, dairy intolerant; and , age 4-1/2, GERD, dairy intolerant -- currently has polysaccharide antibody def, previously had transient IgG, IgA, t-cell & other defs) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 6, 2003 Report Share Posted September 6, 2003 Dear Lynn, I am so sorry you have had to go thru this. What is an ARD? Are you in a private school? We just finished s 504 plan. All 6 of s teachers were present along with the school nurse and his school counselor. We had material from IDF, showed a very brief video of s treatment, and stated s issues. also has similar issues. is 13......... He needs to use the bathroom without asking...........if he waits to ask it will be to late. It states in his 504 that he can leave the classroom without question to use the bathroom. He does not need to ask. He can not drink out of water faucets. He has a bottle of water in every classroom. The nurses office also has a supply for him. There are days as you explained that is exhausted and as soon as school is out he falls asleep in the car and sleeps for the rest of the day.........Homework is excused on those days. He frequently has to lay his head down on his desk.......no problem. monitors his pain, when it gets to the point where he can not handle it he can call me.......no questions asked........he is not to wait in the nurses office to see if it gets better. If there is a major test and is struggling with fatigue .......he will try the test but may not be able to complete it or may bomb it........he can retake when feeling well. I will give the week that will need his infusion and the teachers will let me know if there is something important on that day and I will try to schedule on another day. We also have a young lady who has CF and has a bacteria that is harmful to . Thankfully they are in different grades and only share three teachers.......not at the same time. So when enters and exits those rooms he MUST wash/Purell his hands. There is a bottle of Purell in each class. He also can not use the school computers without washing his hands. because of this bacteria. They were going to give us a lap top but has one. Don't panic about this bacteria...........its only in 5 % of CF patients and only harmful if they are in the same room.............thus they will never be in the nurses office together. wants to be as normal as possible and to be honest with you most people who don't really know would have no idea!!! As for your school, as a parent with a child with medical issues you have rights. Have you ever had a meeting with the teacher and principal.sound like you are in elementary. I would have a meeting ASAP and make sure they fully understand her needs.........backed up by a doctors letter stating the need for bathroom........ It could be the teacher has no idea. If after meeting with them and no changes have been made then I would look into your rights............Im not sure how it applies to private schools. we have not needed an IEP as our school district has been wonderful meeting our request. And thus far has not abused his " privileges " Well, hopefully the teacher just doest't understand, I would push for a meeting ASAP and also considering keeping my child out until the meeting happens, thus the child will not feel the pressure of a teacher not understanding.............if you don't see a 100% change I would demand a new teacher! Also if the school knows you are not returning until the meeting They will schedule it ASAP! Be careful how you come across. You don't want to threaten at this stage of the game but you can make it clear that you are concerned about what has taken place thus far and the effect it is having on your child...Then if you are not satisfied get a patients advocate to help. Take some deep breaths and try to relax this weekend, le Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 7, 2003 Report Share Posted September 7, 2003 As an FYI, I called IDF this week because Charlie started preschool back up after his summer session, and they wanted to go over everything with his health with his new teacher, who is WONDERFUL by the way, anyway, I wanted to get some idea from IDF about what I should be telling them. The woman I spoke with at IDF said they are in the process of putting together a letter for schools! Dayna Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 7, 2003 Report Share Posted September 7, 2003 Hi Lynn, here, I just spoke with my Mom. State and Federal Law has an act, The No Child Left Behind Act. By not accommodating Sis, the teacher and the school are breaking federal law( and as it is you are not asking for much). She said do not go to the teacher but to the Principal, and request a meeting this week with Principal and the Special Ed dept. and talk over what Sis needs( hopefully as an IEP) you need to get everything in writing, if they don't make your meeting you should go to the Superintendent of Schools and Commissioner of Education for your state. She believes Sis should be taken out of this teachers class, something you can request and given to a teacher who can handle children( she said it's ridiculous that a teacher cannot handle 22 kids). If you get nowhere tell them you want an impartial hearing, have everything in writing you need, if you get just one thing on your list( be it drinking from her water bottle , going to the bathroom as needed, a copy of the lesson plans etc( and you will win) the school district has to pay all lawyer fees. She says use the legal aspect as a last resort but let them know you will go through legal channels if necessary. I have to say every time I think of what you are going through I get so mad. I hope this may help. Please let me know if there are any other questions. I am going to put 's 504 on next for those who want to read it. Mom to Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 8, 2003 Report Share Posted September 8, 2003 thank you for replying. This morning when I took Sis in, her teacher had the lesson plan with her, only half of it again. I told her I needed the stuff she does to keep Sis on task for she's not at school. She told me there is not any reason that I should have the rest of the lesson plan, since I'm not teahcing that at home. I told her I wanted her Math, Reading book sent back home with her in the pm because we still had work not finished from last week. When I picked Sis up, I checked her backpack, books not in there. I told Sis to go right back to her classroom and get her math and reading. She came running down the hall in tears and said the teacher told her " there is no reason your mom should have these books, you are not taking them " . I was standing there talking to a intern principal, I told her that is what I'm up against. Then the teacher came around the corner with the two books. She told me there was not one reason I should have those books. I told her we had unfinished work at home. She said the rest of the class was not caught up on the week;s schedule, that Sis was ahead of the class now, since we had finished part of the work. She said it confuses Sis, and makes the rest of the class upset for us to be ahead. I informed her Sis wouldn't be there tommorow also, maybe not the rest of the week if the doc wants more tests done. She rolled her eyes and huffed at me. Oh! And let me back up, this morning I told her that she has GOT to tell me if Sis can't see straight, or gets dizzy, complains of her head hurting, that since her pressure in her brain is going up again, her skull could crack. She and the secretary there both rolled their eyes and said " whatever, she looks fine to us " . So I left, barely made it to my car before I was bawling like a baby. I called my husband he couldn't understand me. I had also requested her not go outside, it was a level red today. They gave me the whatever with that too. I told my husband I should go back in there and get her, that I was terrified of them not saying anything, then her dying, because of them being petty. So, I guess I'm just going to buy a math book from the book company. And the reading also. I don't know what else to do. I'm literally pulling my hair out. Well, not pulling it out, but it's falling out all over the place. I'm completely grey. I was coloring it, but when it started falling out I quit. I finally went to a salon, they said it wasn't the coloring, it was nerves, stress. But it's coming out in handfulls. I have to clean the drain a few times when taking a shower. I'm not even 40 yet, pushing it, but not there yet. okay, she's not going ot sleep, and it's way past her bedtime. The phone just rang again with another creditor. The bills are heaping, we're late on everything. Barely making the major bills. Any advise on how to pay bills without money? Thank you to you all for listening ot me rattle. Lynne Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 9, 2003 Report Share Posted September 9, 2003 LIsa: No sleep again last night. Thank you for replying. We have the neuro appt. today, I wish I could crawl back in bed though. Thank you again for the info. Lynne Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 9, 2003 Report Share Posted September 9, 2003 LIsa: No sleep again last night. Thank you for replying. We have the neuro appt. today, I wish I could crawl back in bed though. Thank you again for the info. Lynne Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 9, 2003 Report Share Posted September 9, 2003 Hi Lynne, I just saw your post, amazing. I also read the post from Dayna. I agree. go right to the Superintendent of Schools and the School board. Don't let them get away with this. I realize how stressful this must be but they have to be stopped. They are breaking all kinds of federal laws by not accommodating Sis, as well as their ethical and moral views are screwed up. This teacher must be reprimanded. That is something else Mom had said, if the teacher continues write everything down and go complain at a school board meeting and demand to have her reprimanded.( Personally, she needs to be fired for her attitude). What kind of plan do you have through the school system? Is Texas that different from NY, we have 504 plans and IEP. Her plan should cover everything, her drinking her water as needed, bathroom privileges as needed, an extra set of books for home, full daily lesson plans to be sent home, also what the teacher and staff should look for in signs of trouble, etc. There is nothing that is over the top. The special Ed dept( the woman is a jerk) at our school told me yesterday that she has kids whose plans are 5 pages long and they have to be accommodated, the school doesn't have a choice. I have a name and number for you, Mr. Eugene Lenz, 512-463-9414, fax 512-463-9434 e-mail- glenz@... . This is your state director of Special Education for Texas. This website is for the National Association of State Directors of Special Education- nasdse.org . this site may also be helpful. I would use every gun in my arsenal at this point to stop the injustice you are receiving. Mr. Lenz is the top guy and should be able to help you. Please let me know how things go. Get Sis out of that teachers class immediately, no child should go through this, no parent either. As a side, when I went to give 's new 504 plan to the head of the Special Ed dept, I walked in the office, no secretary around, I stood there for several minutes, the door to her office was open, she heard the door open and close but wouldn't acknowledge who came in the door, so after several minutes I went to her office and politely knocked, " May I give you this update to 's 504 Plan? " she looked at me and said " What would you do if I said no, would you walk out and leave? " I just looked at her, " No, not until you take it and look it over " I said. So she did take it, and look it over and again didn't want to supply a tutor on an as needed basis for . I told her you don't have a choice this year, if she has a tough time with absences and fatigue you will help her, failing is not an option. They are now moving her meeting up to some time in September, hopefully in the next week or two, we'll see how it goes. Our prayers are with you all, if you need anything let me know. mom to IgA def, asthma, gerd. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 9, 2003 Report Share Posted September 9, 2003 Hi Lin, I think it's time for you to call a meeting with the Principal, the teacher, the school nurse and possibly the school counselor. Have your Doc's write letters to take with you. Everyone needs to be on the same page--which means what is best for Sis. You shouldn't have to go through this. Sandi--Mom to , age 10. Immune Deficiency, Tetrology of Fallot, Mitral Valve stenosis, chronic sinusitis, chronic ear infections, asthma, severe allergies, GERD, Pulmonary Valve Transplant--July 18. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 9, 2003 Report Share Posted September 9, 2003 Sandi: Thank you for replying. Today we had the appt. with the doc, he said to pull her out of school, he's going to sign a homebound form. He said with her pressure in her brain up, she doesn't need the added pressure from the school. He's ordering a MRI, with a scan of her spine also. He's going to get a second opionion from another neurologist. He was furious that the other neuro wasn't taking anything seriously. So I feel a lot better that now things are rolling. Thank you. Lynne Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 16, 2003 Report Share Posted September 16, 2003 Hi Lynne, My daughter has lots of bony growth on her knuckles in both hands. We saw a rhematologist to find out the cause and he mentioned that it may be the result of a vascular condition of some sort. So these things can be caused for a number of reasons. Probably would be a good idea to get this checked out. Martha (mom to IgA deficiency etc.) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 3, 2003 Report Share Posted October 3, 2003 In a message dated 10/2/2003 11:45:36 PM Eastern Daylight Time, Bejenski@... writes: Please pray for us to have the knowledge and wisdom we need to make the right decisions here, to do the Lord's will, not our own. Thanks for listening Lynne, I am so sorry. And definitely praying hard. It is unbelievable and unacceptable for that teacher to talk that way to you. I still say you should call the district superintendent and complain LOUDLY. I will pray that you get answers at the appointment. No answers sucks. Praying hard!!! Diane, Mom to Kody, age 7, precious and precocious who has Di Syndrome, Hypogammaglobulinemia, epilepsy, asthma, chronic encopresis, and severe cognitive regression. Also Mom to Arika age 16, Kaila, age 12, and Sami age 9 (she happens to also be Dyslexic), and wife/soulmate to for 10 years. check out my website: www.geocities.com/schmidtzoo/SNAK Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 3, 2003 Report Share Posted October 3, 2003 In a message dated 10/2/2003 11:45:36 PM Eastern Daylight Time, Bejenski@... writes: Please pray for us to have the knowledge and wisdom we need to make the right decisions here, to do the Lord's will, not our own. Thanks for listening Lynne, I am so sorry. And definitely praying hard. It is unbelievable and unacceptable for that teacher to talk that way to you. I still say you should call the district superintendent and complain LOUDLY. I will pray that you get answers at the appointment. No answers sucks. Praying hard!!! Diane, Mom to Kody, age 7, precious and precocious who has Di Syndrome, Hypogammaglobulinemia, epilepsy, asthma, chronic encopresis, and severe cognitive regression. Also Mom to Arika age 16, Kaila, age 12, and Sami age 9 (she happens to also be Dyslexic), and wife/soulmate to for 10 years. check out my website: www.geocities.com/schmidtzoo/SNAK Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 3, 2003 Report Share Posted October 3, 2003 In a message dated 10/2/03 8:49:57 PM Pacific Daylight Time, Bejenski@... writes: > Please pray for us to have the knowledge and wisdom we need to make the > right decisions here, to do the Lord's will, not our own. Hi Lynne, I know I'm a broken record, but I'm going to say it anyway. Listen to your gut. It will never steer you wrong. Also, regarding the homebound teacher--the work is different when they work with a tutor. It is simply NOT the classroom, and the instruction is completely different. They work one on one almost exclusively. has a tutor three days a week, on the off days, he works on his own. Don't let them give you *rap!!!! I love having a tutor because it frees me up to be a single Mom not to mention caregiver. What can I say, I can't do it all??? Even with the tutor, I work with him on two days a week. Sandi--Mom to , age 10. Immune Deficiency, Tetrology of Fallot, Mitral Valve stenosis, chronic sinusitis, chronic ear infections, asthma, severe allergies, GERD, Pulmonary Valve Transplant--July 18. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 3, 2003 Report Share Posted October 3, 2003 Lynn, I would be happy to talk about what curricula I use and how we homeschool. If you would like to chat, please contact me directly. Pam wife to (16 years) mother to , 9, Hannah, 7, Rebekah, 4, and Leah, 2 Rebekah has CVID and maybe some other stuff Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 3, 2003 Report Share Posted October 3, 2003 Diane: Thank you for replying. This new set of docs agreed with the other. BUT they at least did some other tests, then told me this wasn't a neurology problem, that I needed to go see a orthopedic doctor, that the " bubbles " up her spine were not neuro. He had her bend over, then pushed his hand up her back, at half way up she started screaming. He said that is why they can't find what it is, that it's probably bone structure, not neuro. So off we go to another doc. Please keep sending the prayers up! Thanks, Lynne Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 3, 2003 Report Share Posted October 3, 2003 Sandi: Thank you for replying. Lynne Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 30, 2009 Report Share Posted May 30, 2009 Hello Sis ~ I am so glad you are feeling better, sorry about the tick and the meds you are having to take, but so glad you feel better ! ! Here is a couple articles I found, that may help some or stimulate more questions............ One theory on many illnesses, or symptoms of illness is an underlying infection, or mycoplasma, mycotoxin or nano-bacteria, etc.....I think that may be possible in implanted devices........no matter how steril they think their OR ( operating room ) is, maybe organisms still enter the body............. or......... perhaps it is pseudo type infection, the body " thinks " there is an infection so it acts on it.....either way, something is reacting ..... In the article below, even tho it is talking about the endometrial cells, it talks about how dox alters the production of several inflammatory-related cytokines/chemokines . Mix that with how silicone can cause silicone toxicity, chemical toxicity and biotoxicity from mold, ( some patients have all three problems ), but most patients with prolonged silicone exposure ( via leak or rupture),develop immune, endocrine, and neurological problems, and some autoimmune, (with certain HLA types.) So..........so many variables.........but here with doxy, looks like Dox altered the production of several inflammatory-related cytokines/chemokines allowing for some positive changes. Doxycycline definition - Medical and Health Information on the Common Cold and Flu on MedicineNet.com Doxycycline : Brand name: Vibramycin. A synthetic broad-spectrum antibiotic derived from tetracycline . Doxycycline is used for many different types of infections, including respiratory tract infections due to Hemophilus influenzae, Streptococcus pneumoniae, or Mycoplasma pneumoniae. It is also used for the treatment of nongonococcal urethritis (due to Ureaplasma), Rocky Mountain spotted fever, typhus, chancroid, cholera , brucellosis, syphilis, and acne . Doxycycline is also of relevance to bioterrorism since the CDC (US Centers for Disease Control & Prevention) recommends it as "the drug of choice" for anyone who may have been exposed to anthrax. Doxycycline has fewer side effects, costs less and is more available than Cipro. AND.............................................................................. Click here: Doxycycline alters the expression of inflammatory and immune-related cytokines and chemokines in human endometrial http://humrep.oxfordjournals.org/cgi/content/full/21/10/2555 I will only put part of the discussion below, but for the full article, click on the above links................ In recent years, Dox has been studied at subantimicrobial concentrations in human and animal diseases that are characterized by high levels of pro-inflammatory mediators and protease activities, the diseases including osteoarthritis, rheumatoid arthritis, adult periodontitis and pelvic inflammatory disorder . Under these conditions, Dox therapy has been shown to inhibit/reduce the local production of pro-inflammatory mediators and protease activities, resulting in an enhanced reparative process. During menstruation and in women who experience irregular uterine bleeding due to progesterone-only or progesterone-dominant contraceptives, the endometrial environment is also characterized by elevated levels of pro-inflammatory mediators and protease activity Therefore, Dox therapy may be useful for the management of irregular bleeding/spotting in women using these contraceptives. Using isolated human ESC, GEC and HES cell lines as in vitro model, we tested this hypothesis and demonstrated that Dox altered the production of several inflammatory-related cytokines/chemokines, without having a significant cytotoxicity, except at high doses. However, the effect of Dox on the production of these cytokines and chemokines varied from an inhibitory or stimulatory effect to no significant change. Additionally, Dox treatment altered the production of cytokines/chemokines in these cells co-treated with E2, MPA and E2 + MPA as well as cells treated with TNF-, representing the endometrial environment exposed to contraceptives as well as inflammatory conditions, respectively, in a cell-, steroid- and cytokine-dependent manner. How Dox regulates the expression of these and other inflammatory mediators in endometrial cells is yet to be established; considering the cell-type and cytokine-dependent action of Dox, with differential interaction with ovarian steroids and pro-inflammatory mediators, the therapeutic benefit of Dox is likely to involve a complex molecular mechanism(s). However, the results support the hypothesis that Dox, acting independent of its antimicrobial property, regulates the endometrial cytokine/chemokine production, thereby altering their autocrine/paracrine actions that lead to endometrial inflammatory response. **************We found the real ‘Hotel California’ and the ‘Seinfeld’ diner. What will you find? Explore WhereItsAt.com. (http://www.whereitsat.com/#/music/all-spots/355/47.796964/-66.374711/2/Youve-Found-Where-Its-At?ncid=emlcntnew00000007) Quote Link to comment Share on other sites More sharing options...
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