SCD reduces risk factors for cardiovascular disease and maybe colon cancer

[Guest guest]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra\

ct&list_uids=11288049&query_hl=14

1: Metabolism. 2001 Apr;50(4):494-503.

Related Articles, Links

Effect of a very-high-fiber vegetable, fruit, and nut diet on serum

lipids and colonic function.

DJ, Kendall CW, Popovich DG, Vidgen E, Mehling CC, Vuksan V,

Ransom TP, Rao AV, Rosenberg-Zand R, Tariq N, Corey P, PJ,

Raeini M, Story JA, Furumoto EJ, Illingworth DR, Pappu AS, Connelly

PW.

Clinical Nutrition and Risk Factor Modification Center, Department

of Medicine, Division of Endocrinology and Metabolism, St. 's

Hospital, Toronto, Quebec, Canada.

We tested the effects of feeding a diet very high in fiber from

fruit and vegetables. The levels fed were those, which had

originally inspired the dietary fiber hypothesis related to colon

cancer and heart disease prevention and also may have been eaten

early in human evolution. Ten healthy volunteers each took 3

metabolic diets of 2 weeks duration. The diets were: high-vegetable,

fruit, and nut (very-high-fiber, 55 g/1,000 kcal); starch-based

containing cereals and legumes (early agricultural diet); or low-fat

(contemporary therapeutic diet). All diets were intended to be

weight-maintaining (mean intake, 2,577 kcal/d). Compared with the

starch-based and low-fat diets, the high-fiber vegetable diet

resulted in the largest reduction in low-density lipoprotein (LDL)

cholesterol (33% +/- 4%, P <.001) and the greatest fecal bile acid

output (1.13 +/- 0.30 g/d, P =.002), fecal bulk (906 +/- 130 g/d, P

<.001), and fecal short-chain fatty acid outputs (78 +/- 13 mmol/d,

P <.001). Nevertheless, due to the increase in fecal bulk, the

actual concentrations of fecal bile acids were lowest on the

vegetable diet (1.2 mg/g wet weight, P =.002). Maximum lipid

reductions occurred within 1 week. Urinary mevalonic acid excretion

increased (P =.036) on the high-vegetable diet reflecting large

fecal steroid losses. We conclude that very high-vegetable fiber

intakes reduce risk factors for cardiovascular disease and possibly

colon cancer. Vegetable and fruit fibers therefore warrant further

detailed investigation. Copyright 2001 by W.B. Saunders Company

Publication Types:

Clinical Trial

Randomized Controlled Trial

PMID: 11288049 [PubMed - indexed for MEDLINE]