Re: pycnogenol raises glutathione

November 8, 2009

Thanks Merson,

Great article on the value of this supplement to raise glutathione, which is

something we all could probably use. I had no idea, though I used pycnogenol

when I first got sick. I haven't used it in many years. Are you using it?

This stuff can get expensive, can't it. An average sized person would need to

take about 60 mg a day for at least a month. Iherb has some decent prices on the

NOW brand.

Thanks again...good reminder of a helpful supplement!

Patty

>

> 1mg/kg/day of pycnogenol normalized glutathione after 1 month.

>

> Redox Rep. 2006;11(4):163-72.

>

> The effect of polyphenolic extract from pine bark, Pycnogenol on the level of

glutathione in children suffering from attention deficit hyperactivity disorder

(ADHD).

> Dvoráková M, Sivonová M, Trebatická J, Skodácek I, Waczuliková I, Muchová J,

Duracková Z.

>

> Department of Medical Chemistry, Biochemistry and Clinical Biochemistry,

Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.

>

> Attention deficit hyperactivity disorder (ADHD) belongs to the

neurodevelopmental disorders characterized by impulsivity, distractibility and

hyperactivity. In the pathogenesis of ADHD genetic and non-genetic factors play

an important role. It is assumed that one of non-genetic factors should be

oxidative stress. Pycnogenol, an extract from the pine bark, consists of

bioflavonoids, catechins, procyanidins and phenolic acids. Pycnogenol acts as

powerful antioxidant, chelating agent; it stimulates the activities of some

enzymes, like SOD, eNOS, and exhibits other biological activities. AIM: The aim

of this randomized, double-blind, placebo-controlled trial was to investigate

the influence of administered Pycnogenol or placebo on the level of reduced

(GSH) and oxidized (GSSG) glutathione in children suffering from ADHD and on

total antioxidant status (TAS). This is the first investigation of the redox

glutathione state in relation to ADHD. RESULTS: One month of Pycnogenol

administration (1 mg/kg body weight/day) caused a significant decrease in GSSG

and a highly significant increase in GSH levels as well as improvement of

GSH/GSSG ratio in comparison to a group of patients taking a placebo. TAS in

children with ADHD was decreased in comparison with reference values. Pycnogenol

administration normalizes TAS of ADHD children.

>

November 8, 2009

It can get very expensieve. Mine was $30Cdn for a 50 day supply. I constantly

struggle iwth what to buy/what to take as Idon't want to overdo it either.

I have SIBO and sulfury things like ALA and NAC bother me so this pycnogoenol is

something I could try.

I haven't yet - I just received it.

> >

> > 1mg/kg/day of pycnogenol normalized glutathione after 1 month.

> >

> > Redox Rep. 2006;11(4):163-72.

> >

> > The effect of polyphenolic extract from pine bark, Pycnogenol on the level

of glutathione in children suffering from attention deficit hyperactivity

disorder (ADHD).

> > Dvoráková M, Sivonová M, Trebatická J, Skodácek I, Waczuliková I, Muchová J,

Duracková Z.

> >

> > Department of Medical Chemistry, Biochemistry and Clinical Biochemistry,

Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.

> >

> > Attention deficit hyperactivity disorder (ADHD) belongs to the