Fw: [BreastImplantSurvivorNetwork] Antimicrobial coating agents: can biofilm formation on a breast implant be preve

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This is from our Sweet Dede....love to all....Lea

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 This comes from our Dede, who has done so much research...love you Dede...Lea

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Sent: Thursday, June 04, 2009 10:22 AM

Subject: [breastImplantSurvivorNetwork] Antimicrobial coating agents: can biofilm formation on a breast implant be preve

My Question is : Why are so many implants contaminated with STAPH ? ? We had a couple gals with low grade staph infectionin their breasts for years and years and upon explantationthey exploded into a huge problem......SummaryBackgroundNumerous clinical studies have shown that biofilm formation by Staphylococcus epidermidis on the outer surface of a silicone breast implant is strongly associated with capsular contracture formation. Traditional administration of systemic antibiotics and antiseptic washing are not necessarily the most effective methods for the prevention of initial biofilm formation on implants in the clinical scenario. In this study an alternative or supplement was sought for preventing or delaying bacterial colonisation and adherence to the outer surface of a breast implant, by establishing an in vitro model for investigating this complex problem. The in vitro antimicrobial activity of several antimicrobial agents was investigated for inhibitory effects on biofilm formation by S. epidermidis.MethodsThe study consisted of two experiments. The first experiment consisted of two groups (A and of seven discs each whilst the second experiment was divided into three groups (C, D and E) of 14 discs each. Each group of 14 consisted of seven smooth and seven textured discs. Discs (biopsies) of each implant were individually coated with one of six different antimicrobial agents. Controls that received no agent were included in the various experimental groups. In the first experiment disc diffusion sensitivity testing was performed and inhibition zone sizes were measured. In the second experiment the discs were cultured in broth. The degree of biofilm formation was evaluated by scanning electron microscopy (SEM).ResultsIn the first in vitro experiment, all six agents showed a measurable antimicrobial effect against the biofilm-forming strain of S. epidermidis when compared to the effect against the American Type Culture Collection strain. In the second in vitro experiment, discs coated with Chloramex®, Fucidin® and Terramycin® did not allow biofilm formation to take place for at least 7 days.ConclusionsStaphylococcus epidermidis biofilm formation on the outer surface of a silicone breast implant was prevented in vitro for at least 7 days by coating with an appropriate antimicrobial agent. Further evaluation of the interaction between antimicrobial coating agents and S. epidermidis biofilm formation needs to be made before conclusions regarding the clinical scenario can be drawn.ScienceDirect - Articles Related Platinum in silicone breast implants Antimicrobial coating agents: can biofilm formation on a breast implant be prevented?Journal of Plastic, Reconstructive & Aesthetic Surgery, Volume 62, Issue 5, May 2009, Pages 610-617Johan van Heerden, , Danie Hoffmann, Johan Moolman Preview Purchase PDF (719 K) | Related Articles**************We found the real ‘Hotel California’ and the ‘Seinfeld’ diner. What will you find? Explore WhereItsAt.com. (http://www.whereitsat.com/#/music/all-spots/355/47.796964/-66.374711/2/Youve-Found-Where-Its-At?ncid=emlcntnew00000007)