Fw: POST:Old report: Multiple myelom & replies and Implants in the news....MGUS

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Lea

Sent: Friday, September 05, 2008 9:32 AM

Subject: Fw: POST:Old report: Multiple myelom & replies and Implants in the news....

Sent: Monday, January 12, 2004 7:41 AM

Subject: POST:Old report: Multiple myelom & replies and Implants in the news....

This is an old report (1994) and I am not sure but I think a Dr. from FDA was doing a study on Multiple myeloma and silicone women.Kathy NyeRecord: 1Silicone gel stimulates tumors in mice. By: Marino, G. . Science News ,7/23/94, Vol. 146 Issue 4, p54, 1/2p ; ( AN 9407287524 ) Section SCIENCE NEWS of the week SILICONE GEL STIMULATES TUMORS IN MICE Silicone gel breast implants -- widely available until the Food and DrugAdministration issued a marketing moratorium on them 2 years ago --spark passionate rhetoric. Those who review them as dangerous fault FDAfor not requiring rigorous testing earlier, while those who regard theimplants as relatively safe chide the naysayers. The FDA issued its moratorium on the use of the implants after reportslinked them to connective-tissue and autoimmune diseases. But earlierthis year, a study completed at the Mayo Clinic found little evidence tosupport that link (SN: 6/18/94, p. 389). Now, a new study says the same silicone gel used in implants causes arare cancer in genetically susceptible strains of mice. The findings,reported in the July 20 JOURNAL OF THE NATIONAL CANCER INSTITUTE,confirm that silicon gel-injected into the abdomen of certain mice willproduce plasmacytomas, or tumors caused by the proliferation of plasmacells in bone and connective tissue. "Based on the amount of data we now have, extrapolating from the mousemodel to the human model is titillating but dangerous," says studycoauthor Potter of the National Cancer Institute in Bethesda,Md. In humans, Potter says, plasma cell cancer appears infrequently. Themost common manifestation of a human plasma cell proliferation ismonoclonal gammopathy of undetermined significance (MGUS), whichproduces benign tumors. Potter calls MGUS "an immunological wart"because it isn't usually dangerous; however, MGUs can develop intomultiple myeloma, which is. Multiple myeloma -- cancer of bone and marrow plasma cells -- accountsfor 1 percent of all human cancers. It rarely spreads from bone to otherparts of the body and is found most commonly in people between ages 50and 60. In mice, however, plasma cell cancer remains in the peritoneal cavity.This distinction makes the authors wary about drawing hasty conclusions."The tumors in the two species have many similar properties," saysPotter, "but they have many dissimilar properties as well. The mouse isnot a true model . . . of multiple myeloma, although there are manyinteresting similarities between the two." Pearson, program director of the National Women's Health Networkin Washington, D.C., says the study "seems reasonably balanced" but addsthat "sometimes rats and mice aren't accurate predictors. But itcertainly isn't something we should ignore." Says Sydney E. Salmon of the University of Arizona College of Medicinein Tucson, "finding a few cases doesn't mean there's a casualrelationship. About 1.3 million women have received breast implants, andthe incidence of myeloma is in the range of 3 per 100,000 per year. Youcan then calculate that over a period of 3 to 4 years, 170 women whohave silicone breast implants will develop myeloma" unrelated to theimplants. Even so, in an accompanying editorial, Salmon and A. of theMayo Clinic in Rochester, Minn., call on women who have receivedsilicone implants and have been diagnosed with MGUS, multiple myeloma,or other monoclonal gammopathies to report their diagnosis to the FDA.If warranted, a proper epidemiological study should be conducted, Salmonsays. "I have no doubt some cases will be identified -- if nothing else,just on chance alone." ~~~~~~~~By G. Marino Copyright of Science News is the property of Science News and itscontent may not be copied or emailed to multiple sites or posted to alistserv without the copyright holder's express written permission.However, users may print, download, or email articles for individualuse. Source: Science News, 7/23/94, Vol. 146 Issue 4, p54, 1pItem: 9407287524===========================================================Subj: Re: What else will they come to a conclusion on? Date: 1/11/2004 10:29:39 PM Eastern Standard Time From: Dowlied @aol.comWell if you ask me, if it hadn't been for the implants, none of us would have been on any psychiatric or anxiety drugs, and in fact all that I have talked too were never on any of these types of drugs or showed signs and syptoms of any problems until the D word came along and the good docs that think all women need on some kind of "nerve medication" because she is a woman and you know how they like to think that we are all stupid and don't know our bodies anyway, and if god forbid that we disagree with any man muchless a doctor we are all crazy anyway!Sorry, just got a headache tonite, but thats just me being overly hypochondriatic (don't know if thats a word or not, lol).===========================================================I find humor in both of these, I would laugh, but it hurts too much.Kathy NyeBREAST Implants: Continue to Be CautiousNewsweekBy H. Shmerling, MD. Dec. 8 issue - For a while this fall, it lookedas if silicone breast implants were poised to make a comeback. ...<http://msnbc.msn.com/id/3606199/>NEW Organic Breast Implants Being RecalledThe Spoof (News Satire), UKTittyCorp, a manufacturer of the now outlawed silicon breast implants,has been ordered to recall their latest organic based breast implants,called ...<http://www.thespoof.com/news/spoof.cfm?headline=s5i1665>