RE: Similar Disorders to MSA --> CBGD, PSP & LBD

[Guest guest]

There are 4 disorders that are very similar to each other. We've had people

who thought they had MSA but autopsy revealed one of the other three. Some

cases of CBGD and PSP can't even be distinguished from each other with

autopsy... so there is a really blurred line between those two disorders.

MSA and LBD are most similar to each other clinically and both have the

protein " alpha-synuclein " involved in neurodegeneration. CBGD and PSP both

have the protein " tau " involved in neurodegeneration.

Multiple System Atrophy (MSA) --> alpha-synuclein protein disorder

http://www.emedicine.com/NEURO/topic671.htm

Lewy Body Dementia (LBD) --> alpha-synuclein protein disorder

http://www.emedicine.com/NEURO/topic91.htm

Corticobasal Ganglionic Degeneration (CBGD)--> tau protein disorder

http://www.emedicine.com/NEURO/topic77.htm

Progressive Supranuclear Palsy (PSP)--> tau protein disorder

http://www.ninds.nih.gov/health_and_medical/disorders/psp.htm

There is a research center at the University of Pennsylvania which is

studying all of these disorders. See: http://www.uphs.upenn.edu/cndr/ This

center will be involved in the MSA Research Study led by Dr. Cliff Shults.

Drs. Viginia Lee and Trojanowski (husband and wife team) are the main

researchers at this center.

Regards,

Pam

Re: - Belinda

Jerrie,

I am not sure. Maybe Pam can answer this question for you. I do not

have OH. I have high blood pressure instead of low blood pressure. I

think and I am not sure but I think it affects the brain more also. I

will try to figure it out for you but one of my lense just fell out

of my glasses and I have a hard time reading without them.

God bless,

Belinda

> Belinda: What is the differrence between CBDG & MSA? My husband

was dx

> with MSA, so I curious. Thanks. Regards,

jerrie

[Guest guest]

Hi Pam,

Thanks for that answer, that explains why my neuro

said I have either MSA, CBGD, OR PSP. The only one he

did not included was LBD. And who knows, that could

change with time as well. He thing is none are

curable so lets treat the best we can. Belinda said

she does not have the low bp, but has high bp. HeHe,

I have both. Depending of various factors that I have

not yet to figure out my bp lying and standing can be

very high, but does still drop alot when I go from

lying to standing. Right now I am on the low side

everyday. Saw dr today and her nurse said she gives

up figuring out whether I am " normal " for me or not.

It changes everytime I go in. The dr herself has set

what she considers acceptable limits to her and if I

fall in that range she is happy and today she was on

the verge of unhappy. I do not know which disorder I

have and there fore would not even know which if any

study I would qualify for, but some day I would like

to be in a study.

thanks

wanda

--- Pam Bower pbower@...> wrote:

> There are 4 disorders that are very similar to each

> other. We've had people

> who thought they had MSA but autopsy revealed one of

> the other three. Some

> cases of CBGD and PSP can't even be distinguished

> from each other with

> autopsy... so there is a really blurred line between

> those two disorders.

> MSA and LBD are most similar to each other

> clinically and both have the

> protein " alpha-synuclein " involved in

> neurodegeneration. CBGD and PSP both

> have the protein " tau " involved in

> neurodegeneration.

>

> Multiple System Atrophy (MSA) --> alpha-synuclein

> protein disorder

> http://www.emedicine.com/NEURO/topic671.htm

>

> Lewy Body Dementia (LBD) --> alpha-synuclein protein

> disorder

> http://www.emedicine.com/NEURO/topic91.htm

>

>

> Corticobasal Ganglionic Degeneration (CBGD)--> tau

> protein disorder

> http://www.emedicine.com/NEURO/topic77.htm

>

> Progressive Supranuclear Palsy (PSP)--> tau protein

> disorder

>

http://www.ninds.nih.gov/health_and_medical/disorders/psp.htm

>

>

> There is a research center at the University of

> Pennsylvania which is

> studying all of these disorders. See:

> http://www.uphs.upenn.edu/cndr/ This

> center will be involved in the MSA Research Study

> led by Dr. Cliff Shults.

> Drs. Viginia Lee and Trojanowski (husband and

> wife team) are the main

> researchers at this center.

>

> Regards,

> Pam

>

> Re: - Belinda

>

>

> Jerrie,

> I am not sure. Maybe Pam can answer this question

> for you. I do not

> have OH. I have high blood pressure instead of low

> blood pressure. I

> think and I am not sure but I think it affects the

> brain more also. I

> will try to figure it out for you but one of my

> lense just fell out

> of my glasses and I have a hard time reading without

> them.

> God bless,

> Belinda

>

>

>

> > Belinda: What is the differrence between CBDG &

> MSA? My husband

> was dx

> > with MSA, so I curious. Thanks.

> Regards,

> jerrie

>

>

>

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