Maggie - Duvoid; PEG - hydration

[Guest guest]

This was the aryticle my doctor gave me when he first decided to try me on

Duvoid (Bethanochol Chloride)

At that time I was completely unable to 'make water'. Since then not only

has the incidence of edema (in my case abdominal) and urinary retention

become rare, I have more tears (though still insufficient) and a little

more salivation (which helps when eating). I started at 20 mg 3 times a

day and am now taking 30 mg 3 x day. I am suprised it is not more widely

used. I am even more surprised that after many years of having this

problem and seeing many specialists none had ever thought to try me on it.

It is quite inexpensive and I have had no unpleasant side effects and have

now used it for six months.

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AU - Khurana RK

TI - Cholinergic dysfunction in Shy-Drager syndrome: effect of the

parasympathomimetic agent, bethanechol.

AD - Autonomic Reflex Laboratory, Union Memorial Hospital, Baltimore, MD.

AB - To determine the frequency, severity and organ distribution of

cholinergic dysfunction in the Shy-Drager syndrome, eleven

patients were prospectively studied. In addition to documenting adrenergic

insufficiency, a battery of twelve tests was employed

to assess cholinergic function. Six tests demonstrated pupillary, lacrimal,

salivary, urinary bladder, sexual and sudomotor

dysfunction in the majority of patients. Cardiac vagal function as studied

by the heart rate response to deep breathing, the

Valsalva manoeuvre, cold face test, apnoeic facial immersion and atropine

test was affected in all patients. Oesophageal motility

was abnormal in six patients. Cholinergic dysfunction in patients with the

Shy-Drager syndrome was widespread but of variable

severity and distribution. Subcutaneous administration of the

parasympathomimetic agent bethanechol demonstrated

hyperresponsiveness of lacrimal, salivary, oesophageal, bowel, bladder and

sudomotor functions. It is suggested that the

Shy-Drager syndrome is primarily a preganglionic cholinergic disorder with

transsynaptic degeneration accounting for the

development of postganglionic cholinergic as well as adrenergic dysfunction.

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Hope that helps some of you.

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Subject: post from Aletta

Hi Aletta,

Thanks for writing about your medication! We have never heard of Duvoid. Do

you know if it is different in ingredients than Detrol or Flomax? Did you

try other scripts before settling on Duvoid? We would be very interested to

hear your experience in this area. 's urologist says that the bulk of

his frequency and urgency problems are due to an enlarged prostate. The

doctor just never takes (remembers?) 's other health concerns and

prescriptions into consideration....Those that have taken an oath to do no

harm could easily " kill " patients if they (the patients) weren't able to

remember everything and advocate for their own health/survival.

takes Lopressor to stabilize his bp and he has not had OH

episodes since starting it. On Florinef and the other one (Amantadine I

think it was) he still experienced much OH, landing in the hospital 7 times

with the really bad spells. The Dr.

(Neurologist) would only let him stay on Florinef a year, because he has

heart problems too.

Maggie CP 64/53PD/51? Michigan

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A PEG tube sounds wonderful, I spend way to much of my life trying to get

things down. Before this discussion I thought a PEG meant you had to stop

eating and drinking completely, and I was afraid of how dry my mouth would

become. The dryness already causes much pain and makes it hard to talk

(when your tongue stick to your teeth). I'd like a little more detail in

how this affects mobility (if at all), and if a person can manage this when

they have no help at home. Other than a PEG, are there other ways of

helping with hydration (daily IV?) stuff like that.

aletta mes, vancouver, bc canada

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Site: http://www.aletta.0catch.com