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Re: Viagra & MSA

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Trudi:

You may want to talk to the Urologist about Viagra and other things that can be used. My Husband tried Viagra but it didn't really work that well for him, also he had alot of down time after ( I know Bill I opened the door on that one :o) ..). He also tried something called Muse with it you use a ring. That worked so-so. The last thing that the Urologist gave him to try was a Penial Injection. This seem to work better for him then the other's for awhile. It really doesn't hurt them because it's given into the side where there is no feeling. The doctor will show you how to do it. There will come a day that nothing helps and you need to be open minded and talk about that also. There maybe other things out that may help, but these were the things that Fred tried and I know something about.

Take Care

Vera

***********************

From: Pam Bower <pbower@a...>

Date: Tue Feb 26, 2002 8:26 am

Subject: Re: Viagra & MSA

Hi Trudi,

The below research article discusses the results of a

study done in the UK on viagra in men with MSA and

Parkinsons. Viagra did help but you need to be very

cautious with it's use because it can lower blood

pressure. Keep this in mind and make sure to discuss

it with the doctor and make them aware of this study.

Take care,

Pam

--- Trudi Croker <Trudi.Croker@C...>

wrote:

> Dear Pam or anyone who may be able to help...

>

> I would like to know if you have any information on

> impotency with MSDA? Is

> there any medication? Would taking Viagra have an

> adverse affect?

>

> Many thanks

>

> Trudi

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Trudi:

You may want to talk to the Urologist about Viagra and other things that can be used. My Husband tried Viagra but it didn't really work that well for him, also he had alot of down time after ( I know Bill I opened the door on that one :o) ..). He also tried something called Muse with it you use a ring. That worked so-so. The last thing that the Urologist gave him to try was a Penial Injection. This seem to work better for him then the other's for awhile. It really doesn't hurt them because it's given into the side where there is no feeling. The doctor will show you how to do it. There will come a day that nothing helps and you need to be open minded and talk about that also. There maybe other things out that may help, but these were the things that Fred tried and I know something about.

Take Care

Vera

***********************

From: Pam Bower <pbower@a...>

Date: Tue Feb 26, 2002 8:26 am

Subject: Re: Viagra & MSA

Hi Trudi,

The below research article discusses the results of a

study done in the UK on viagra in men with MSA and

Parkinsons. Viagra did help but you need to be very

cautious with it's use because it can lower blood

pressure. Keep this in mind and make sure to discuss

it with the doctor and make them aware of this study.

Take care,

Pam

--- Trudi Croker <Trudi.Croker@C...>

wrote:

> Dear Pam or anyone who may be able to help...

>

> I would like to know if you have any information on

> impotency with MSDA? Is

> there any medication? Would taking Viagra have an

> adverse affect?

>

> Many thanks

>

> Trudi

Link to comment
Share on other sites

Hi Trudi,

The below research article discusses the results of a

study done in the UK on viagra in men with MSA and

Parkinsons. Viagra did help but you need to be very

cautious with it's use because it can lower blood

pressure. Keep this in mind and make sure to discuss

it with the doctor and make them aware of this study.

Take care,

Pam

--- Trudi Croker Trudi.Croker@...>

wrote:

> Dear Pam or anyone who may be able to help...

>

> I would like to know if you have any information on

> impotency with MSDA? Is

> there any medication? Would taking Viagra have an

> adverse affect?

>

> Many thanks

>

> Trudi

J Neurol Neurosurg Psychiatry 2001 Sep;71(3):371-4

Treatment of erectile dysfunction with sildenafil

citrate (Viagra) in parkinsonism due to Parkinson's

disease or multiple system atrophy with observations

on orthostatic hypotension.

Hussain IF, Brady CM, Swinn MJ, Mathias CJ, Fowler CJ.

Uro-Neurology, National Hospital for Neurology and

Neurosurgery, Queen Square, London WC1N 3BG, UK.

OBJECTIVES: To assess the efficacy and safety of

sildenafil citrate (Viagra) in men with erectile

dysfunction and parkinsonism due either to Parkinson's

disease or multiple system atrophy.

METHODS: Twenty four patients with erectile disease

were recruited, 12 with Parkinson's disease and 12

with multiple system atrophy, into a randomised,

double blind, placebo controlled, crossover study of

sildenafil citrate. The starting dose was 50 mg active

or placebo medication with the opportunity for dose

adjustment depending on efficacy and tolerability.

The international index of erectile function

questionnaire (IIEF) was used to assess treatment

efficacy and a quality of life questionnaire to assess

the effect of treatment on sex life and whole life.

Criteria for entry included a definite neurological

diagnosis and a standing systolic blood pressure of

90-180 mm Hg and diastolic blood pressure of 50-110 mm

Hg, on treatment if necessary. Blood pressure was

taken at randomisation (visit 2) and crossover (visit

5) lying, sitting, and standing, before and 1 hour

after taking the study medication in hospital.

RESULTS: Sidenafil citrate was efficacious in men with

parkinsonism with a significant improvement, as

demonstrated in questionnaire responses, in ability to

achieve and maintain an erection and improvement in

quality of sex life. In Parkinson's disease there was

minimal change in blood pressure between active and

placebo medication. In multiple system atrophy, six

patients were studied before recruitment was stopped

because three men showed a severe drop in blood

pressure 1 hour after taking the active medication.

Two

were already known to have orthostatic hypotension and

were receiving treatment with ephedrine and midodrine

but the third had asymptomatic hypotension.

However, the blood pressures in all three had been

within the inclusion criterion for the study protocol.

Despite a significant postural fall in blood

pressure after sildenafil, all patients with multiple

system atrophy reported a good erectile response and

were reluctant to discontinue the medication.

CONCLUSIONS: Sidenafil citrate (50 mg) is efficacious

in the treatment of erectile dysfunction in

parkinsonism due to Parkinson's disease or multiple

system atrophy; however, it may unmask or exacerbate

hypotension in multiple system atrophy. As Parkinson's

disease may be diagnostically difficult to distinguish

from multiple system atrophy, especially in the early

stages, we recommend measurement of lying and standing

blood pressure before prescribing sildenafil to men

with parkinsonism. Furthermore, such patients should

be made aware of seeking medical advice if they

develop symptoms on treatment suggestive of

orthostatic hypotension.

Publication Types:

Clinical Trial

Randomized Controlled Trial

PMID: 11511713 [PubMed - indexed for MEDLINE]

>

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