Guest guest Posted June 9, 2002 Report Share Posted June 9, 2002 I would second Tony's request especially from the standpoint of affects on the functions controlled by the autonomic system. Message: 12 Date: Sun, 09 Jun 2002 13:55:32 -0000 Subject: Opiates and MSA Hey, All- Does anyone know of any studies relating to long-term use of synthetic opiate painkillers and symptoms of MSA? Tony in Boston Sennewald Charlottesville, Virginia Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 10, 2002 Report Share Posted June 10, 2002 Pam, Thank you so much for the information on this. Wow! Thanks!! Jean (Phx) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 10, 2002 Report Share Posted June 10, 2002 Pam, Thank you so much for the information on this. Wow! Thanks!! Jean (Phx) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 10, 2002 Report Share Posted June 10, 2002 Pam, Thank you so much for the information on this. Wow! Thanks!! Jean (Phx) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 10, 2002 Report Share Posted June 10, 2002 Yes I've heard of a derivative of a synthetic opiate causing Parkinson symptoms and destroying dopamine cells... please read on. Hugs, Pam -------- http://www.nyu.edu/classes/azmitia/lectures/lecture08/ CAUSE OF P.D. Although we have uncovered many of the brain mechanisms involved in PD, the actual cause of this disease is unknown. One theory holds that free radicals may cause cell death.(explain free radicals and anti-oxidants) Other theories hold that specific neuro-toxins can cause dopamine neurons to die. Certain pesticides and other environmental toxins present in our food supply have been proposed as potential toxins. This theory is based on observations of a toxin called MPTP. Spouses of PD patients are at higher risk of developing PD. Hinting at a possible shared exposure to a toxin. Genetics may also play a role however only a small percentage of PD cases can be traced to hereditary factors. The MPTP Story: Taken from The Case of the Frozen Addicts by Langston and Palfreman. 1976 a chemistry student named Barry Kidston, living in land was using a home laboratory to synthesize various drugs for his own recreational use. He had become interested in synthesizing a chemical called MPPP (an analog of Demerol, a potent opiate similar to heroine). For several months, Barry synthesized MPPP and injected it intravenously without incident. But on one occasion he was in a hurry and took some shortcuts in the chemical procedure. When he injected he compound it produced a powerful burning sensation. Within 3 days he was exhibiting such severe bradykinesia that he was unable to speak or move. He was hospitalized and initially diagnosed as a catatonic schizophrenic and put on neuroleptics(which worsened his condition WHY?). Eventually a neurologist diagnosed Parkinson's diease and prescribed L-Dopa and Kidston's symptoms started improving. The National Institute of Mental Health was notified of this rare case and sent a team to Kidston's home. Fortunately a small amount of the toxic drug he had synthesized was still clinging to his glassware. When the compound was analyzed it was found to contain trace amounts of MPTP, an unanticipated by product due to the chemical shortcuts Kidston had used. A chemist tested MPPP and MPTP on rats. The rats exhibited parkinson like symptoms but their symptoms only lasted a few hours. (As it turns out, rats were the wrong choice to test on because they are now known to show resistance to MPTP's neurotoxic action. A few years later, in 1982, 6 people in California suddenly manifested severe parkinsonian like symptoms. Doctors were baffled because these people were too young and their symptoms emerged too rapidly to be indicative of typical Parkinson's disease. It was then determined that all of these patients were heroin users who had tried a new batch of drug a few days before. This batch had also been sythesized by an amateur chemist who had intended to synthesize MPPP. These patients also responded well to L Dopa. Eventually Burns, Kopin were able to induce parkinson's symptoms in rhesus monkeys after administration of MPTP. When they examined their brains they found extreme loss of dopamine cell bodies in the SN. MPTP when administered crosses the Blood Brain Barrier and is converted by MAO-B into MPP+ which is taken up into dopamine cells by the Dopamine transporter and then causes cell death. MPTP lead scientists to a greater understanding of the DA system as well as develop theories of how parkinson's might be partially caused or accelerated by specific toxins. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 10, 2002 Report Share Posted June 10, 2002 Yes I've heard of a derivative of a synthetic opiate causing Parkinson symptoms and destroying dopamine cells... please read on. Hugs, Pam -------- http://www.nyu.edu/classes/azmitia/lectures/lecture08/ CAUSE OF P.D. Although we have uncovered many of the brain mechanisms involved in PD, the actual cause of this disease is unknown. One theory holds that free radicals may cause cell death.(explain free radicals and anti-oxidants) Other theories hold that specific neuro-toxins can cause dopamine neurons to die. Certain pesticides and other environmental toxins present in our food supply have been proposed as potential toxins. This theory is based on observations of a toxin called MPTP. Spouses of PD patients are at higher risk of developing PD. Hinting at a possible shared exposure to a toxin. Genetics may also play a role however only a small percentage of PD cases can be traced to hereditary factors. The MPTP Story: Taken from The Case of the Frozen Addicts by Langston and Palfreman. 1976 a chemistry student named Barry Kidston, living in land was using a home laboratory to synthesize various drugs for his own recreational use. He had become interested in synthesizing a chemical called MPPP (an analog of Demerol, a potent opiate similar to heroine). For several months, Barry synthesized MPPP and injected it intravenously without incident. But on one occasion he was in a hurry and took some shortcuts in the chemical procedure. When he injected he compound it produced a powerful burning sensation. Within 3 days he was exhibiting such severe bradykinesia that he was unable to speak or move. He was hospitalized and initially diagnosed as a catatonic schizophrenic and put on neuroleptics(which worsened his condition WHY?). Eventually a neurologist diagnosed Parkinson's diease and prescribed L-Dopa and Kidston's symptoms started improving. The National Institute of Mental Health was notified of this rare case and sent a team to Kidston's home. Fortunately a small amount of the toxic drug he had synthesized was still clinging to his glassware. When the compound was analyzed it was found to contain trace amounts of MPTP, an unanticipated by product due to the chemical shortcuts Kidston had used. A chemist tested MPPP and MPTP on rats. The rats exhibited parkinson like symptoms but their symptoms only lasted a few hours. (As it turns out, rats were the wrong choice to test on because they are now known to show resistance to MPTP's neurotoxic action. A few years later, in 1982, 6 people in California suddenly manifested severe parkinsonian like symptoms. Doctors were baffled because these people were too young and their symptoms emerged too rapidly to be indicative of typical Parkinson's disease. It was then determined that all of these patients were heroin users who had tried a new batch of drug a few days before. This batch had also been sythesized by an amateur chemist who had intended to synthesize MPPP. These patients also responded well to L Dopa. Eventually Burns, Kopin were able to induce parkinson's symptoms in rhesus monkeys after administration of MPTP. When they examined their brains they found extreme loss of dopamine cell bodies in the SN. MPTP when administered crosses the Blood Brain Barrier and is converted by MAO-B into MPP+ which is taken up into dopamine cells by the Dopamine transporter and then causes cell death. MPTP lead scientists to a greater understanding of the DA system as well as develop theories of how parkinson's might be partially caused or accelerated by specific toxins. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 10, 2002 Report Share Posted June 10, 2002 Yes I've heard of a derivative of a synthetic opiate causing Parkinson symptoms and destroying dopamine cells... please read on. Hugs, Pam -------- http://www.nyu.edu/classes/azmitia/lectures/lecture08/ CAUSE OF P.D. Although we have uncovered many of the brain mechanisms involved in PD, the actual cause of this disease is unknown. One theory holds that free radicals may cause cell death.(explain free radicals and anti-oxidants) Other theories hold that specific neuro-toxins can cause dopamine neurons to die. Certain pesticides and other environmental toxins present in our food supply have been proposed as potential toxins. This theory is based on observations of a toxin called MPTP. Spouses of PD patients are at higher risk of developing PD. Hinting at a possible shared exposure to a toxin. Genetics may also play a role however only a small percentage of PD cases can be traced to hereditary factors. The MPTP Story: Taken from The Case of the Frozen Addicts by Langston and Palfreman. 1976 a chemistry student named Barry Kidston, living in land was using a home laboratory to synthesize various drugs for his own recreational use. He had become interested in synthesizing a chemical called MPPP (an analog of Demerol, a potent opiate similar to heroine). For several months, Barry synthesized MPPP and injected it intravenously without incident. But on one occasion he was in a hurry and took some shortcuts in the chemical procedure. When he injected he compound it produced a powerful burning sensation. Within 3 days he was exhibiting such severe bradykinesia that he was unable to speak or move. He was hospitalized and initially diagnosed as a catatonic schizophrenic and put on neuroleptics(which worsened his condition WHY?). Eventually a neurologist diagnosed Parkinson's diease and prescribed L-Dopa and Kidston's symptoms started improving. The National Institute of Mental Health was notified of this rare case and sent a team to Kidston's home. Fortunately a small amount of the toxic drug he had synthesized was still clinging to his glassware. When the compound was analyzed it was found to contain trace amounts of MPTP, an unanticipated by product due to the chemical shortcuts Kidston had used. A chemist tested MPPP and MPTP on rats. The rats exhibited parkinson like symptoms but their symptoms only lasted a few hours. (As it turns out, rats were the wrong choice to test on because they are now known to show resistance to MPTP's neurotoxic action. A few years later, in 1982, 6 people in California suddenly manifested severe parkinsonian like symptoms. Doctors were baffled because these people were too young and their symptoms emerged too rapidly to be indicative of typical Parkinson's disease. It was then determined that all of these patients were heroin users who had tried a new batch of drug a few days before. This batch had also been sythesized by an amateur chemist who had intended to synthesize MPPP. These patients also responded well to L Dopa. Eventually Burns, Kopin were able to induce parkinson's symptoms in rhesus monkeys after administration of MPTP. When they examined their brains they found extreme loss of dopamine cell bodies in the SN. MPTP when administered crosses the Blood Brain Barrier and is converted by MAO-B into MPP+ which is taken up into dopamine cells by the Dopamine transporter and then causes cell death. MPTP lead scientists to a greater understanding of the DA system as well as develop theories of how parkinson's might be partially caused or accelerated by specific toxins. Quote Link to comment Share on other sites More sharing options...
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