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Attached is some studies I found interesting and thought you may be interested in reading them also.

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Judy & Jim Stark

Don't see the condition you are looking for below? Click here to see a complete list of alternate names.Condition List:

Acne ADHD ADHD (Pediatric) Allergic Rhinitis Allergies Allergies - Pediatric Alopecia Alzheimer's Disease Amyloidosis Amyotrophic Lateral Sclerosis (ALS) Anemia Aneurysm Angina Ankylosing Spondylitis Anxiety Disorders Arrhythmias Arthritis Asthma Asthma - Pediatric Atherosclerosis Back Pain Benign Prostatic Hyperplasia (BPH) Bipolar Disorders Bladder Cancer Bleeding Disorders Blood Disorders Blood Disorders - Other Bone Marrow Disorders Brain Tumors Breast Cancer Bronchitis Burns Bursitis/Tendonitis Cancer - Bone & Soft Tissue Cancer - Brain & Nervous System Cancer - Digestive/GI Cancer - Endocrine Cancer - Eye Cancer - Kidney/Urology Cancer - Nose & Throat Cancer - Other Cancer - Pediatric Cancer - Uterus/Endometrium Cancer Related Disorders Cardiovascular Disease Cataracts Cervical Cancer Chemical Dependency/Substance Abuse Chlamydia Chronic Fatigue Syndrome Circulation Disorders Coagulation Disorders Colon Cancer Common Cold Conjunctivitis Connective Tissue Diseases COPD Coronary Artery Disease Crohn's Disease Cystic Fibrosis Cystitis Dementia Dental Disorders Depression Dermatitis Diabetes Diabetes - Complications Diabetic Foot Ulcers Diabetic Neuropathy Dystonia/Dykinesias Ear Disorders Ear Infections Eating Disorders Eczema Emphysema Endocrine Disorders - Other Endometriosis Epilepsy Epilepsy - Pediatric Erectile Dysfunction Eye Disorders - Other Eye Infections Female Reproductive Disorders Fibrocystic Breast Disease Fibromyalgia Gall Bladder Disorders Gastroesophageal Reflux Disease (GERD) Gastrointestinal Disorders - Other Genetic Disorders Gestational Diabetes Glaucoma Gonorrhea Gout Gynecological Disorders - Other Headaches Hearing Disorders Heart Attack/Myocardial Infarction Heart Failure Hemochromatosis Hepatitis A Hepatitis B Hepatitis C Hepatitis-Other Herpes High Cholesterol HIV/AIDS Hodgkin's Disease Hormonal Disorders - Other Hypercalcemia Hypertension Hypoglycemia Immune Disorders - Other Impetigo Incontinence Infections - Pediatric Infectious Disease - Other Inflammatory Disorders - Other Influenza/Flu Irritable Bowel Syndrome (IBS) Irritable Bowel Syndrome (IBS) - Pediatric Kidney Disorders Kidney Disorders - Pediatric Leukemia Leukopenia Liver Cancer Liver Disorders Lung Cancers Lung Disorders Lupus (SLE) Lyme Disease Lymphatic Disorders Lymphomas Macular Degeneration Male Reproductive Disorders Menopause/HRT Menstrual Disorders Metabolic Disorders Migraine - Pediatric Migraines Miscellaneous Conditions Multiple Sclerosis Musculoskeletal Disorders - Other Myeloma Nasal Disorders Nausea And Vomiting Neurological Disorders - Other Obesity Obsessive Compulsive Disorder Osteoarthritis Osteoporosis Otolargynology Disorders - Other Ovarian Cancer Ovarian Cysts/Polycystic Ovaries Pain Pancreatic Cancer Pancreatic Disorders Panic Disorder Parathyroid Disorders Parkinson's Disease Pediatric Disorders - Other Pediatric-HIV Pelvic Inflammatory Disease Peripheral Vascular Disease Pituitary Disorders Pneumonia Post-Traumatic Stress Disorder (PTSD) Pregnancy Complications Prostate Cancer Prostatitis Psoriasis Psychiatric Disorders - Other Psychiatric Disorders - Pediatric Radiology Recurrent Urinary Tract Infections Renal Dialysis Renal Failure Respiratory Disorders - Other Rheumatoid Arthritis Rheumatoid Arthritis - Pediatric Sarcomas Schizophrenia Scleroderma Seizure Disorders Sepsis Sexual Dysfunction Sexually Transmitted Diseases - Other Sickle Cell Sinus Infections Sinusitis Skin Cancers - Melanoma Skin Cancers - Other Skin Disorders - Other Sleep Disorders Smoking Cessation Spinal Cord Disorders Stroke Syphilis Testicular Cancers Thalessemia Thrombosis Thyroid Cancer Thyroid Disorders Trauma Tumors - Pediatric Ulcerative Colitis Ulcers Urology/Nephrology Disorders - Other Uterine Fibroids Vaginitis Valvular Disease Vascular Disease Venous Ulcers Yeast Infections

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Somnocheck for Obstructive Sleep Apnea

Source: HopkinsHealthby: HopkinsHealth10/17/2001

Loud snoring by one member of a couple is frequently the butt of jokes and skits, often centered around how the nonsnorer attempts to cope. But snoring is no laughing matter, largely because it is often a symptom of obstructive sleep apnea. Someone who has obstructive sleep apnea actually ceases to breathe for short periods during sleep. Breathing cessation causes the brain to rouse the person from sleeping in order to restart breathing. Many repetitions of this process result in little sleep at night and daytime sleepiness for the person with sleep apnea. More recent research also suggests a link between obstructive sleep apnea and high blood pressure, with other links starting to emerge. Now a new device that can be used at home has been developed to help assess whether someone has obstructive sleep apnea, but Neubauer, M.D., assistant professor of psychiatry and associated director of the Sleep Disorders Center at s Hopkins, tells HopkinsHealth that more testing is needed before the device's utility is proven.

How is this new device used?

Dr. Neubauer: The device is called Somnocheck, and it basically records two possible parameters that may be indicative of sleep apnea: how much oxygen is in someone's blood and the amount of air that flows through their airway. Somnocheck requires the user to wire themselves up to the device before they go to bed. While they are sleeping, data is gathered. In many ways this is not very different from how a formal sleep study is done because such a study also requires being hooked up to recording devices via wires. The Somnocheck does not record brain wave activity, so it doesn't directly evaluate sleep.

What are the disadvantages of a formal sleep study?

Dr. Neubauer: Most people cite expense and inconvenience as the primary disadvantages, and some people who work in the field of sleep assessment argue that sleep studies done in laboratories don't provide an accurate picture of how people sleep at home. For all of these reasons devices such as Somnocheck seem attractive, but I would like to see studies performed in the home setting, since this is where the screening usually would take place.

Since symptoms of sleep apnea are so well defined, is a sleep study really necessary?

Dr. Neubauer: Yes, it is. We really can't back into a diagnosis of sleep apnea based on symptoms or the presence of risk factors, such as being male or overweight. In order for us to take the next step into management or treatment, we must be sure of the diagnosis.

Do you see an eventual place for devices such as Somnocheck in evaluating sleep apnea?

Dr. Neubauer: I think such devices will likely have a place in screening, but until they get a good deal more sophisticated they won't replace formal sleep studies done in a laboratory. Questions they are unable to answer include how much a reduction in breathing affects sleep, that is, how often does someone wake up as a result? Subtler disruptions in breathing and sleep cannot be evaluated either. Sleep apnea runs a continuum, with different people experiencing a unique set of symptoms. This device and others like it are too crude at this point to be useful for evaluating less obvious disruptions.

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Don't see the condition you are looking for below? Click here to see a complete list of alternate names.Condition List:

Acne ADHD ADHD (Pediatric) Allergic Rhinitis Allergies Allergies - Pediatric Alopecia Alzheimer's Disease Amyloidosis Amyotrophic Lateral Sclerosis (ALS) Anemia Aneurysm Angina Ankylosing Spondylitis Anxiety Disorders Arrhythmias Arthritis Asthma Asthma - Pediatric Atherosclerosis Back Pain Benign Prostatic Hyperplasia (BPH) Bipolar Disorders Bladder Cancer Bleeding Disorders Blood Disorders Blood Disorders - Other Bone Marrow Disorders Brain Tumors Breast Cancer Bronchitis Burns Bursitis/Tendonitis Cancer - Bone & Soft Tissue Cancer - Brain & Nervous System Cancer - Digestive/GI Cancer - Endocrine Cancer - Eye Cancer - Kidney/Urology Cancer - Nose & Throat Cancer - Other Cancer - Pediatric Cancer - Uterus/Endometrium Cancer Related Disorders Cardiovascular Disease Cataracts Cervical Cancer Chemical Dependency/Substance Abuse Chlamydia Chronic Fatigue Syndrome Circulation Disorders Coagulation Disorders Colon Cancer Common Cold Conjunctivitis Connective Tissue Diseases COPD Coronary Artery Disease Crohn's Disease Cystic Fibrosis Cystitis Dementia Dental Disorders Depression Dermatitis Diabetes Diabetes - Complications Diabetic Foot Ulcers Diabetic Neuropathy Dystonia/Dykinesias Ear Disorders Ear Infections Eating Disorders Eczema Emphysema Endocrine Disorders - Other Endometriosis Epilepsy Epilepsy - Pediatric Erectile Dysfunction Eye Disorders - Other Eye Infections Female Reproductive Disorders Fibrocystic Breast Disease Fibromyalgia Gall Bladder Disorders Gastroesophageal Reflux Disease (GERD) Gastrointestinal Disorders - Other Genetic Disorders Gestational Diabetes Glaucoma Gonorrhea Gout Gynecological Disorders - Other Headaches Hearing Disorders Heart Attack/Myocardial Infarction Heart Failure Hemochromatosis Hepatitis A Hepatitis B Hepatitis C Hepatitis-Other Herpes High Cholesterol HIV/AIDS Hodgkin's Disease Hormonal Disorders - Other Hypercalcemia Hypertension Hypoglycemia Immune Disorders - Other Impetigo Incontinence Infections - Pediatric Infectious Disease - Other Inflammatory Disorders - Other Influenza/Flu Irritable Bowel Syndrome (IBS) Irritable Bowel Syndrome (IBS) - Pediatric Kidney Disorders Kidney Disorders - Pediatric Leukemia Leukopenia Liver Cancer Liver Disorders Lung Cancers Lung Disorders Lupus (SLE) Lyme Disease Lymphatic Disorders Lymphomas Macular Degeneration Male Reproductive Disorders Menopause/HRT Menstrual Disorders Metabolic Disorders Migraine - Pediatric Migraines Miscellaneous Conditions Multiple Sclerosis Musculoskeletal Disorders - Other Myeloma Nasal Disorders Nausea And Vomiting Neurological Disorders - Other Obesity Obsessive Compulsive Disorder Osteoarthritis Osteoporosis Otolargynology Disorders - Other Ovarian Cancer Ovarian Cysts/Polycystic Ovaries Pain Pancreatic Cancer Pancreatic Disorders Panic Disorder Parathyroid Disorders Parkinson's Disease Pediatric Disorders - Other Pediatric-HIV Pelvic Inflammatory Disease Peripheral Vascular Disease Pituitary Disorders Pneumonia Post-Traumatic Stress Disorder (PTSD) Pregnancy Complications Prostate Cancer Prostatitis Psoriasis Psychiatric Disorders - Other Psychiatric Disorders - Pediatric Radiology Recurrent Urinary Tract Infections Renal Dialysis Renal Failure Respiratory Disorders - Other Rheumatoid Arthritis Rheumatoid Arthritis - Pediatric Sarcomas Schizophrenia Scleroderma Seizure Disorders Sepsis Sexual Dysfunction Sexually Transmitted Diseases - Other Sickle Cell Sinus Infections Sinusitis Skin Cancers - Melanoma Skin Cancers - Other Skin Disorders - Other Sleep Disorders Smoking Cessation Spinal Cord Disorders Stroke Syphilis Testicular Cancers Thalessemia Thrombosis Thyroid Cancer Thyroid Disorders Trauma Tumors - Pediatric Ulcerative Colitis Ulcers Urology/Nephrology Disorders - Other Uterine Fibroids Vaginitis Valvular Disease Vascular Disease Venous Ulcers Yeast Infections

Find your condition in the left column. Next to it, in parentheses, is the Acurian condition that will contain the information for your selected condition. Just click on the term and we'll automatically bring you to the appropriate Acurian condition page.Click on the first letter of the term you are looking for.A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z --------------------------------------------------------------------------------------------------------------------------------------

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Heart Drugs Might Help Treat Apnea

Source: Associated Pressby: Jeff Donn, Associated Press Writer02/06/2002

BOSTON (AP) - A cardiologist became curious why heart patients who had been given pacemakers were suddenly snoring less. What he found out could transform doctors' understanding of apnea and point the way to drug treatments for the sometimes dangerous sleep disorder.Apnea sufferers stop breathing for 10 seconds to a minute or more, a condition that can rouse them hundreds of times a night. Apnea sufferers tend to snore loudly.The condition can leave people exhausted by day and in danger of dozing off while driving. Scientists also believe apnea contributes to high blood pressure and heart disease.But a team of French doctors, led by cardiologist Stephane Garrigue, found in a study that faster heart rates caused by pacemakers can relieve apnea.That stands on end the prevailing theory that apnea acts on the heart. It means the heart can also act on apnea."In patients with normal heart rhythm, maybe it's the occasion to develop some drugs to increase the heart rate," Garrigue said.The findings, reported in Thursday's New England Journal of Medicine, have intrigued doctors."If you had asked me about this, I would have said it was a long shot," said Dr. Drazen, a respiratory specialist and editor in chief of the journal.Garrigue's medical team at the University of Bordeaux studied 15 heart patients who showed symptoms of sleep apnea.Pacemakers kick in when the heart slips below a certain number of beats per minute. For the study, the researchers increased that number by 15 beats per minute. In this overdrive setting, the patients' hearts would turn on the pacemakers when the rate dropped to around 70 beats a minute.On the overdrive setting, the average hourly number of nighttime breathing lapses dropped 61 percent, from 28 to 11."We were very surprised to have this kind of effect," Garrigue said.Garrigue and other doctors suggested that the faster heart rates may be stimulating various nerves, which then prompt the brain to normalize breathing.Up to 18 million Americans suffer from apnea, according to the National Institutes of Health. The condition is found disproportionately in obese men over 40.Mild cases can often be treated with dieting and sleeping on the stomach or side. Other patients may wear air-pumping masks at night or even undergo surgery to remove a blockage in their airways.Dr. Gottlieb, a respiratory and sleep specialist at Boston University School of Medicine, said the findings suggest apnea might be treatable with drugs, perhaps by quickening the heart or activating the respiratory control center of the brain.However, Dr. Waldhorn, medical director of the Sleep Disorder Center at town University Hospital in Washington, cautioned that the pacemaker overdrive may relieve apnea mainly in patients with heart problems, too.

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Copyright © 2000-2002 Acurian Inc. All Rights Reserved. Acurian, Inc./Acurian, Ltd. Acurian.com is for educational purposes only and should not be used as a substitute for a consultation or visit with your family physician or other healthcare provider. Please read this important legal information. All Rights Reserved.

Don't see the condition you are looking for below? Click here to see a complete list of alternate names.Condition List:

Acne ADHD ADHD (Pediatric) Allergic Rhinitis Allergies Allergies - Pediatric Alopecia Alzheimer's Disease Amyloidosis Amyotrophic Lateral Sclerosis (ALS) Anemia Aneurysm Angina Ankylosing Spondylitis Anxiety Disorders Arrhythmias Arthritis Asthma Asthma - Pediatric Atherosclerosis Back Pain Benign Prostatic Hyperplasia (BPH) Bipolar Disorders Bladder Cancer Bleeding Disorders Blood Disorders Blood Disorders - Other Bone Marrow Disorders Brain Tumors Breast Cancer Bronchitis Burns Bursitis/Tendonitis Cancer - Bone & Soft Tissue Cancer - Brain & Nervous System Cancer - Digestive/GI Cancer - Endocrine Cancer - Eye Cancer - Kidney/Urology Cancer - Nose & Throat Cancer - Other Cancer - Pediatric Cancer - Uterus/Endometrium Cancer Related Disorders Cardiovascular Disease Cataracts Cervical Cancer Chemical Dependency/Substance Abuse Chlamydia Chronic Fatigue Syndrome Circulation Disorders Coagulation Disorders Colon Cancer Common Cold Conjunctivitis Connective Tissue Diseases COPD Coronary Artery Disease Crohn's Disease Cystic Fibrosis Cystitis Dementia Dental Disorders Depression Dermatitis Diabetes Diabetes - Complications Diabetic Foot Ulcers Diabetic Neuropathy Dystonia/Dykinesias Ear Disorders Ear Infections Eating Disorders Eczema Emphysema Endocrine Disorders - Other Endometriosis Epilepsy Epilepsy - Pediatric Erectile Dysfunction Eye Disorders - Other Eye Infections Female Reproductive Disorders Fibrocystic Breast Disease Fibromyalgia Gall Bladder Disorders Gastroesophageal Reflux Disease (GERD) Gastrointestinal Disorders - Other Genetic Disorders Gestational Diabetes Glaucoma Gonorrhea Gout Gynecological Disorders - Other Headaches Hearing Disorders Heart Attack/Myocardial Infarction Heart Failure Hemochromatosis Hepatitis A Hepatitis B Hepatitis C Hepatitis-Other Herpes High Cholesterol HIV/AIDS Hodgkin's Disease Hormonal Disorders - Other Hypercalcemia Hypertension Hypoglycemia Immune Disorders - Other Impetigo Incontinence Infections - Pediatric Infectious Disease - Other Inflammatory Disorders - Other Influenza/Flu Irritable Bowel Syndrome (IBS) Irritable Bowel Syndrome (IBS) - Pediatric Kidney Disorders Kidney Disorders - Pediatric Leukemia Leukopenia Liver Cancer Liver Disorders Lung Cancers Lung Disorders Lupus (SLE) Lyme Disease Lymphatic Disorders Lymphomas Macular Degeneration Male Reproductive Disorders Menopause/HRT Menstrual Disorders Metabolic Disorders Migraine - Pediatric Migraines Miscellaneous Conditions Multiple Sclerosis Musculoskeletal Disorders - Other Myeloma Nasal Disorders Nausea And Vomiting Neurological Disorders - Other Obesity Obsessive Compulsive Disorder Osteoarthritis Osteoporosis Otolargynology Disorders - Other Ovarian Cancer Ovarian Cysts/Polycystic Ovaries Pain Pancreatic Cancer Pancreatic Disorders Panic Disorder Parathyroid Disorders Parkinson's Disease Pediatric Disorders - Other Pediatric-HIV Pelvic Inflammatory Disease Peripheral Vascular Disease Pituitary Disorders Pneumonia Post-Traumatic Stress Disorder (PTSD) Pregnancy Complications Prostate Cancer Prostatitis Psoriasis Psychiatric Disorders - Other Psychiatric Disorders - Pediatric Radiology Recurrent Urinary Tract Infections Renal Dialysis Renal Failure Respiratory Disorders - Other Rheumatoid Arthritis Rheumatoid Arthritis - Pediatric Sarcomas Schizophrenia Scleroderma Seizure Disorders Sepsis Sexual Dysfunction Sexually Transmitted Diseases - Other Sickle Cell Sinus Infections Sinusitis Skin Cancers - Melanoma Skin Cancers - Other Skin Disorders - Other Sleep Disorders Smoking Cessation Spinal Cord Disorders Stroke Syphilis Testicular Cancers Thalessemia Thrombosis Thyroid Cancer Thyroid Disorders Trauma Tumors - Pediatric Ulcerative Colitis Ulcers Urology/Nephrology Disorders - Other Uterine Fibroids Vaginitis Valvular Disease Vascular Disease Venous Ulcers Yeast Infections

Find your condition in the left column. Next to it, in parentheses, is the Acurian condition that will contain the information for your selected condition. Just click on the term and we'll automatically bring you to the appropriate Acurian condition page.Click on the first letter of the term you are looking for.A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z --------------------------------------------------------------------------------------------------------------------------------------

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Complications in Postoperative Patients with Sleep Apnea

Source: Mayo Clinic09/12/2001

ROCHESTER, MINN. -- Patients with obstructive sleep apnea syndrome experienced a greater number of serious medical complications following elective knee or hip replacement surgery than patients without the syndrome, Mayo Clinic researchers report.Adverse postoperative outcomes occurred in 24 percent of the patients with obstructive sleep apnea syndrome compared with nine percent of the patients in the study's control group who did not have the syndrome. The study matched 101 patients with obstructive sleep apnea syndrome with 101 patients without it.The study is published in the September issue of Mayo Clinic Proceedings. Authors of the study are: Rakesh M. Gupta, M.D., now of the Sleep Disorders Center, Medical Center, Providence, R.I.; Javad Parvizi, M.D.; Arlen D. Hanssen, M.D.; and C. Gay, M.D. Drs. Parvizi, Hanssen and Gay are all with Mayo Clinic."Although we intuitively had concerns that obstructive sleep apnea patients undergoing surgery were at increased risk of complications, there is very little information about this," says Dr. Gay, the senior investigator in the study. "We are particularly anxious to bring these findings to the attention of both physicians and patients alike as the possibility of increased risk from sleep apnea during elective surgery is not often aggressively pursued. The next study we wish to pursue is to show that the evaluation and treatment of these patients beforehand, can actually help reduce the increased post-operative risks."The prevalence of obstructive sleep apnea syndrome is estimated at five to nine percent and most often affects obese, middle-aged men. More than half of all cases of sleep apnea are diagnosed in people 40 years of age or older. The condition also is more common in men than women.Obstructive sleep apnea occurs when the muscles in the back of the throat relax. These muscles support the soft palate, uvula, tonsils and tongue. When the muscles relax, the airway is narrowed or closed and breathing is momentarily cut off. This lowers the level of oxygen in the blood. The brain senses this decrease and briefly rouses the person from sleep so that the airways reopen. This awakening is usually so brief that a person doesn't remember it. Breathing resumes, possibly with a snort. This pattern can repeat itself 10 times or more each hour, all night. A person is less able to reach the deep, restful phases of sleep and often feels sleepy during waking hours.In general, only weight loss greater than 10 percent of body weight is thought to have any impact on symptoms caused by sleep apnea, the authors report from a previous study.The authors also reported that the length of hospital stay was significantly longer for patients with sleep apnea (almost seven days) versus patients in the control group (five days).Researchers say the frequency and severity of upper airway obstructions in patients with obstructive sleep apnea syndrome undergoing joint replacement are likely to be high for several reasons. First, because of the nature of the operation, these patients are expected to remain on their back after the operation. Second, uniform use of moderate amounts of intravenous narcotics after the operation is likely to precipitate or aggravate the respiratory complications in patients with obstructive sleep apnea syndrome.The study also found that most complications occur in the first 24 hours. The authors suggest this may be due to the combined effect of the anesthetic agents, sedatives and narcotics, which tend to relax upper airway dilator muscles and increase upper airway resistance, thus aggravating obstructive sleep apnea syndrome.Mayo Clinic Proceedings is a peer-reviewed and indexed general internal medicine journal, published for 75 years by Mayo Foundation, with a circulation of 130,000 nationally and internationally.

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Copyright © 2000-2002 Acurian Inc. All Rights Reserved. Acurian, Inc./Acurian, Ltd. Acurian.com is for educational purposes only and should not be used as a substitute for a consultation or visit with your family physician or other healthcare provider. Please read this important legal information. All Rights Reserved.

Don't see the condition you are looking for below? Click here to see a complete list of alternate names.Condition List:

Acne ADHD ADHD (Pediatric) Allergic Rhinitis Allergies Allergies - Pediatric Alopecia Alzheimer's Disease Amyloidosis Amyotrophic Lateral Sclerosis (ALS) Anemia Aneurysm Angina Ankylosing Spondylitis Anxiety Disorders Arrhythmias Arthritis Asthma Asthma - Pediatric Atherosclerosis Back Pain Benign Prostatic Hyperplasia (BPH) Bipolar Disorders Bladder Cancer Bleeding Disorders Blood Disorders Blood Disorders - Other Bone Marrow Disorders Brain Tumors Breast Cancer Bronchitis Burns Bursitis/Tendonitis Cancer - Bone & Soft Tissue Cancer - Brain & Nervous System Cancer - Digestive/GI Cancer - Endocrine Cancer - Eye Cancer - Kidney/Urology Cancer - Nose & Throat Cancer - Other Cancer - Pediatric Cancer - Uterus/Endometrium Cancer Related Disorders Cardiovascular Disease Cataracts Cervical Cancer Chemical Dependency/Substance Abuse Chlamydia Chronic Fatigue Syndrome Circulation Disorders Coagulation Disorders Colon Cancer Common Cold Conjunctivitis Connective Tissue Diseases COPD Coronary Artery Disease Crohn's Disease Cystic Fibrosis Cystitis Dementia Dental Disorders Depression Dermatitis Diabetes Diabetes - Complications Diabetic Foot Ulcers Diabetic Neuropathy Dystonia/Dykinesias Ear Disorders Ear Infections Eating Disorders Eczema Emphysema Endocrine Disorders - Other Endometriosis Epilepsy Epilepsy - Pediatric Erectile Dysfunction Eye Disorders - Other Eye Infections Female Reproductive Disorders Fibrocystic Breast Disease Fibromyalgia Gall Bladder Disorders Gastroesophageal Reflux Disease (GERD) Gastrointestinal Disorders - Other Genetic Disorders Gestational Diabetes Glaucoma Gonorrhea Gout Gynecological Disorders - Other Headaches Hearing Disorders Heart Attack/Myocardial Infarction Heart Failure Hemochromatosis Hepatitis A Hepatitis B Hepatitis C Hepatitis-Other Herpes High Cholesterol HIV/AIDS Hodgkin's Disease Hormonal Disorders - Other Hypercalcemia Hypertension Hypoglycemia Immune Disorders - Other Impetigo Incontinence Infections - Pediatric Infectious Disease - Other Inflammatory Disorders - Other Influenza/Flu Irritable Bowel Syndrome (IBS) Irritable Bowel Syndrome (IBS) - Pediatric Kidney Disorders Kidney Disorders - Pediatric Leukemia Leukopenia Liver Cancer Liver Disorders Lung Cancers Lung Disorders Lupus (SLE) Lyme Disease Lymphatic Disorders Lymphomas Macular Degeneration Male Reproductive Disorders Menopause/HRT Menstrual Disorders Metabolic Disorders Migraine - Pediatric Migraines Miscellaneous Conditions Multiple Sclerosis Musculoskeletal Disorders - Other Myeloma Nasal Disorders Nausea And Vomiting Neurological Disorders - Other Obesity Obsessive Compulsive Disorder Osteoarthritis Osteoporosis Otolargynology Disorders - Other Ovarian Cancer Ovarian Cysts/Polycystic Ovaries Pain Pancreatic Cancer Pancreatic Disorders Panic Disorder Parathyroid Disorders Parkinson's Disease Pediatric Disorders - Other Pediatric-HIV Pelvic Inflammatory Disease Peripheral Vascular Disease Pituitary Disorders Pneumonia Post-Traumatic Stress Disorder (PTSD) Pregnancy Complications Prostate Cancer Prostatitis Psoriasis Psychiatric Disorders - Other Psychiatric Disorders - Pediatric Radiology Recurrent Urinary Tract Infections Renal Dialysis Renal Failure Respiratory Disorders - Other Rheumatoid Arthritis Rheumatoid Arthritis - Pediatric Sarcomas Schizophrenia Scleroderma Seizure Disorders Sepsis Sexual Dysfunction Sexually Transmitted Diseases - Other Sickle Cell Sinus Infections Sinusitis Skin Cancers - Melanoma Skin Cancers - Other Skin Disorders - Other Sleep Disorders Smoking Cessation Spinal Cord Disorders Stroke Syphilis Testicular Cancers Thalessemia Thrombosis Thyroid Cancer Thyroid Disorders Trauma Tumors - Pediatric Ulcerative Colitis Ulcers Urology/Nephrology Disorders - Other Uterine Fibroids Vaginitis Valvular Disease Vascular Disease Venous Ulcers Yeast Infections

Find your condition in the left column. Next to it, in parentheses, is the Acurian condition that will contain the information for your selected condition. Just click on the term and we'll automatically bring you to the appropriate Acurian condition page.Click on the first letter of the term you are looking for.A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z --------------------------------------------------------------------------------------------------------------------------------------

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MEDICAL NEWS

Caspase Inhibitors Shown to Inhibit Neuronal Cell Death By Darrin KiesslingIdun Pharmaceuticals, Inc., La Jolla, Calif., recently reported results from animal studies designed to evaluate the effectiveness of a new approach to preventing the death of nerve cells in central nervous system (CNS) diseases and brain injuries. Tomaselli, Ph.D., Idun Pharmaceuticals, presented the study results at the 39th Annual Meeting of the American College of Neuropsychopharmacology in San , Puerto Rico, in December 2000. The results demonstrated the ability of the company's proprietary caspase inhibitors to decrease death of neurons - nerve cells -- by a process know as apoptosis.A large proportion of the neuron death observed in CNS diseases and brain injuries is caused by a process known as apoptosis. Apoptosis is genetically controlled "cell suicide" brought about by the action of specific genetic material within cells. When activated by a protein called Apaf-1, a family of cysteine proteases known as caspases is able to open the "gate" controlling apoptosis, and neuron death quickly ensues. Small molecule inhibitors of caspases represent a new approach to inhibiting this process in the context of CNS injuries and diseases."Cell death in the brain is mediated by multiple caspases, which is an important mechanism in the neurodegenerative disease process," said Tomaselli. "Idun's caspase inhibitors have the potential to reduce the brain damage that occurs as a result of injury, as in stroke or trauma, or disease, including Alzheimer's disease."Copyright © 2001 Acurian Inc. All Rights Reserved.This article is a summation of material that is no longer accessible on the Acurian site. All facts, details and references remain consistent with the original material.

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Copyright © 2000-2002 Acurian Inc. All Rights Reserved. Acurian, Inc./Acurian, Ltd. Acurian.com is for educational purposes only and should not be used as a substitute for a consultation or visit with your family physician or other healthcare provider. Please read this important legal information. All Rights Reserved.