Research: Role of gut microbiota in Crohn’s disease

[Guest guest]

Crohn’s disease (CD), a form of inflammatory bowel disease (IBD), provides a

complex model of host†" microbe interactions underpinning disease pathogenesis.

Although there is not widespread agreement on the etiology of CD, there is

evidence that microorganisms lead to the often severe inflammatory response

characteristic of the disease. Despite several microbial candidates, no specific

microbe has been considered pathogenic. Instead, the concept of the

‘pathogenic community’ has emerged from the evidence, whereby the stability

of the microbial ecosystem of the healthy human gut is disrupted in response to

host genetics and destabilized immunity, perhaps through changing public health

practices leading to altered microbial exposures over time. We discuss the

complex microbial ecosystem of the mammalian gut, the underlying genetic factors

that predispose to CD, and how these gene variants may alter host†" microbe

interactions and propagate inflammation. Over the next 5 years, the increased

understanding of genes involved in CD and the way in which individuals with

variants of these genes respond differently to nutrients and drugs will enable

the rational development of personalized therapies, using pharmacogenomic and

nutrigenomic approaches.

http://www.expert-reviews.com/doi/abs/10.1586/egh.09.47

[Guest guest]

Thank you for posting this. The more research looks into intestinal flora-

hopefully the more support SCD will gain:)

PJ

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> Crohn’s disease (CD), a form of inflammatory bowel disease (IBD), provides a

complex model of host†" microbe interactions underpinning disease pathogenesis.

Although there is not widespread agreement on the etiology of CD, there is

evidence that microorganisms lead to the often severe inflammatory response

characteristic of the disease. Despite several microbial candidates, no specific

microbe has been considered pathogenic. Instead, the concept of the

‘pathogenic community’ has emerged from the evidence, whereby the stability

of the microbial ecosystem of the healthy human gut is disrupted in response to

host genetics and destabilized immunity, perhaps through changing public health

practices leading to altered microbial exposures over time. We discuss the

complex microbial ecosystem of the mammalian gut, the underlying genetic factors

that predispose to CD, and how these gene variants may alter host†" microbe

interactions and propagate inflammation. Over the next 5 years, the increased

understanding of genes involved in CD and the way in which individuals with

variants of these genes respond differently to nutrients and drugs will enable

the rational development of personalized therapies, using pharmacogenomic and

nutrigenomic approaches.

> http://www.expert-reviews.com/doi/abs/10.1586/egh.09.47

>