Re: meaning of maternal inheritance

[Guest guest]

Steve

You have the mtDNA defect right. There is also a maternally inherited

form of diseases which is in the nDNA. An example would be Hemophia

and Duchane Muscular Dystrophy. It is my understanding that there are

some forms of mito that can be inherited this way.

Then there is the dominent and recessive if it is nDNA.

Adult onset mito can be inherited by means of mtDNA and nDNA.

This is from my meager knowledge of genetics.

laurie

> Dolores

>

> Just a note regarding your comment below, about great-grandaughters. I'm

> assuming you're referring to " maternal inheritance " . My understanding of the

> term is that, where it applies, it means that one can only inherit something

> from one's mother. In other words, I as a male cannot " give " it to my

> children, and furthermore my father could not have " given " it to me. But

> this term does NOT mean that only females can inherit the disease. Males can

> get it (from their mothers) but then cannot pass it on to their children.

>

> So that means that your great-grandaughters AND your great-grandsons could

> get a maternally-inherited disease " from " you. However, it also means that

> this would only be the case if those great-grandchildren are children of

> your grand-DAUGHTER, who in turn is the child of your DAUGHTER.

>

> Hope I have that right. :-) Also, perhaps I've mis-assumed, and you simply

> made that reference because you don't have any great-grandsons. In which

> case, never mind. :-) It's also true (to my understanding) that maternal

> inheritance does not apply to all mito diseases.

>

> Anyway, my blessings for the best possible health for you, your children,

> your grandchildren, and your great-grandchildren, and so on forever.

>

> Steve D.

>

> > Date: Tue, 31 May 2005 18:02:05 -0700 (PDT)

> >

> > Subject: Re: diagnosis

> >

> > [...] I just try to keep plugging away and pray that my precious

> Great-grandaughters will not have this problem handed down

> > to them. Everytime I see the four month old roll her toes under it

> scares me to death as that was one of the things I used to do for muscle

> spasms a good lot of my life until they got so bad I would jump out of bed

> screaming. I know this really isn't giving answers but I hope in some way

> it will help. Dolores

>

>

>

> Medical advice, information, opinions, data and statements contained herein

are not necessarily those of the list moderators. The author of this e mail is

entirely responsible for its content. List members are reminded of their

responsibility to evaluate the content of the postings and consult with their

physicians regarding changes in their own treatment.

>

> Personal attacks are not permitted on the list and anyone who sends one is

automatically moderated or removed depending on the severity of the attack.

>

>

[Guest guest]

not understanding genetics either my Doc just wrote down for me the

following.... ?autosommal recesssive nuclear gene I loved his

question mark first my personal translation they don't know

LOL and mine is also adult onset...

Gillian

> > Dolores

> >

> > Just a note regarding your comment below, about great-

grandaughters. I'm

> > assuming you're referring to " maternal inheritance " . My

understanding of the

> > term is that, where it applies, it means that one can only

inherit something

> > from one's mother. In other words, I as a male cannot " give " it

to my

> > children, and furthermore my father could not have " given " it to

me. But

> > this term does NOT mean that only females can inherit the

disease. Males can

> > get it (from their mothers) but then cannot pass it on to their

children.

> >

> > So that means that your great-grandaughters AND your great-

grandsons could

> > get a maternally-inherited disease " from " you. However, it also

means that

> > this would only be the case if those great-grandchildren are

children of

> > your grand-DAUGHTER, who in turn is the child of your DAUGHTER.

> >

> > Hope I have that right. :-) Also, perhaps I've mis-assumed, and

you simply

> > made that reference because you don't have any great-grandsons.

In which

> > case, never mind. :-) It's also true (to my understanding) that

maternal

> > inheritance does not apply to all mito diseases.

> >

> > Anyway, my blessings for the best possible health for you, your

children,

> > your grandchildren, and your great-grandchildren, and so on

forever.

> >

> > Steve D.

> >

> > > Date: Tue, 31 May 2005 18:02:05 -0700 (PDT)

> > > From: Dolores

> > > Subject: Re: diagnosis

> > >

> > > [...] I just try to keep plugging away and pray that my

precious

> > Great-grandaughters will not have this problem handed down

> > > to them. Everytime I see the four month old roll her toes

under it

> > scares me to death as that was one of the things I used to do

for muscle

> > spasms a good lot of my life until they got so bad I would jump

out of bed

> > screaming. I know this really isn't giving answers but I hope

in some way

> > it will help. Dolores

> >

> >

> >

> > Medical advice, information, opinions, data and statements

contained herein are not necessarily those of the list moderators.

The author of this e mail is entirely responsible for its content.

List members are reminded of their responsibility to evaluate the

content of the postings and consult with their physicians regarding

changes in their own treatment.

> >

> > Personal attacks are not permitted on the list and anyone who

sends one is automatically moderated or removed depending on the

severity of the attack.

> >

> >

[Guest guest]

not understanding genetics either my Doc just wrote down for me the

following.... ?autosommal recesssive nuclear gene I loved his

question mark first my personal translation they don't know

LOL and mine is also adult onset...

Gillian

> > Dolores

> >

> > Just a note regarding your comment below, about great-

grandaughters. I'm

> > assuming you're referring to " maternal inheritance " . My

understanding of the

> > term is that, where it applies, it means that one can only

inherit something

> > from one's mother. In other words, I as a male cannot " give " it

to my

> > children, and furthermore my father could not have " given " it to

me. But

> > this term does NOT mean that only females can inherit the

disease. Males can

> > get it (from their mothers) but then cannot pass it on to their

children.

> >

> > So that means that your great-grandaughters AND your great-

grandsons could

> > get a maternally-inherited disease " from " you. However, it also

means that

> > this would only be the case if those great-grandchildren are

children of

> > your grand-DAUGHTER, who in turn is the child of your DAUGHTER.

> >

> > Hope I have that right. :-) Also, perhaps I've mis-assumed, and

you simply

> > made that reference because you don't have any great-grandsons.

In which

> > case, never mind. :-) It's also true (to my understanding) that

maternal

> > inheritance does not apply to all mito diseases.

> >

> > Anyway, my blessings for the best possible health for you, your

children,

> > your grandchildren, and your great-grandchildren, and so on

forever.

> >

> > Steve D.

> >

> > > Date: Tue, 31 May 2005 18:02:05 -0700 (PDT)

> > > From: Dolores

> > > Subject: Re: diagnosis

> > >

> > > [...] I just try to keep plugging away and pray that my

precious

> > Great-grandaughters will not have this problem handed down

> > > to them. Everytime I see the four month old roll her toes

under it

> > scares me to death as that was one of the things I used to do

for muscle

> > spasms a good lot of my life until they got so bad I would jump

out of bed

> > screaming. I know this really isn't giving answers but I hope

in some way

> > it will help. Dolores

> >

> >

> >

> > Medical advice, information, opinions, data and statements

contained herein are not necessarily those of the list moderators.

The author of this e mail is entirely responsible for its content.

List members are reminded of their responsibility to evaluate the

content of the postings and consult with their physicians regarding

changes in their own treatment.

> >

> > Personal attacks are not permitted on the list and anyone who

sends one is automatically moderated or removed depending on the

severity of the attack.

> >

> >

[Guest guest]

Gillian

I have to agree with you on that one.

laurie

> not understanding genetics either my Doc just wrote down for me the

> following.... ?autosommal recesssive nuclear gene I loved his

> question mark first my personal translation they don't know

> LOL and mine is also adult onset...

>

> Gillian

>

>

>

>

>

> > > Dolores

> > >

> > > Just a note regarding your comment below, about great-

> grandaughters. I'm

> > > assuming you're referring to " maternal inheritance " . My

> understanding of the

> > > term is that, where it applies, it means that one can only

> inherit something

> > > from one's mother. In other words, I as a male cannot " give " it

> to my

> > > children, and furthermore my father could not have " given " it to

> me. But

> > > this term does NOT mean that only females can inherit the

> disease. Males can

> > > get it (from their mothers) but then cannot pass it on to their

> children.

> > >

> > > So that means that your great-grandaughters AND your great-

> grandsons could

> > > get a maternally-inherited disease " from " you. However, it also

> means that

> > > this would only be the case if those great-grandchildren are

> children of

> > > your grand-DAUGHTER, who in turn is the child of your DAUGHTER.

> > >

> > > Hope I have that right. :-) Also, perhaps I've mis-assumed, and

> you simply

> > > made that reference because you don't have any great-grandsons.

> In which

> > > case, never mind. :-) It's also true (to my understanding) that

> maternal

> > > inheritance does not apply to all mito diseases.

> > >

> > > Anyway, my blessings for the best possible health for you, your

> children,

> > > your grandchildren, and your great-grandchildren, and so on

> forever.

> > >

> > > Steve D.

> > >

> > > > Date: Tue, 31 May 2005 18:02:05 -0700 (PDT)

> > > > From: Dolores

> > > > Subject: Re: diagnosis

> > > >

> > > > [...] I just try to keep plugging away and pray that my

> precious

> > > Great-grandaughters will not have this problem handed down

> > > > to them. Everytime I see the four month old roll her toes

> under it

> > > scares me to death as that was one of the things I used to do

> for muscle

> > > spasms a good lot of my life until they got so bad I would jump

> out of bed

> > > screaming. I know this really isn't giving answers but I hope

> in some way

> > > it will help. Dolores

> > >

> > >

> > >

> > > Medical advice, information, opinions, data and statements

> contained herein are not necessarily those of the list moderators.

> The author of this e mail is entirely responsible for its content.

> List members are reminded of their responsibility to evaluate the

> content of the postings and consult with their physicians regarding

> changes in their own treatment.

> > >

> > > Personal attacks are not permitted on the list and anyone who

> sends one is automatically moderated or removed depending on the

> severity of the attack.

> > >

> > >

[Guest guest]

Thanks Steve, fortunately I only had two living children out of seven

pregnancies and both were sons Bill who is still living and who I lost

very suddenly August 25, 2004 at age 48. His doctors were baffled as to what to

put on the death certificate and they finally went with Kidney Failure, the same

as what happened to my Dad. I have always wondered if there was a chance that

could have had a form of Mito as I had never heard the word until

December, 2004 and then things went forward very rapidly as my orthopaedic

doctor had 32 years of records, tests, illnesses and then he never did accept

the parkinsons diagnosis and ran a wide variety of tests on his own since 2001

and he consulted various times with my neurosurgeon who ran more tests and as

soon as he felt he had all the answers to the puzzle had been gone several

months and I was on my way to Washington State to my cousins for the holidays so

made arrangements for me to see doctors at Seattle and Spokane,

then he fired my neurologist, consulted with my current neurologist about my

case and it has been confusing since December. Is it possible for mutations to

come from both parents, as that is what my cousin and I both thought the doctor

at Spokane told us? If so then could others in my Dad's family be prone to

Mito? I have three grandsons, one of the grandsons and two great-grandsons

belong to my deceased son as well as one grandaughter and one

great-grandaughter are also s. My son Bill is the father of two of my

grandsons and my great-grandaughters belong to his youngest son Jeff. Bill is

52 and is a strong and healthy railroad worker. He drives back and forth from

Topeka to Kansas City everyday to maintain his job working on the tracks for

Burlington Northern-Santa Fe. was like me always had something wrong with

him that no one could quite figure out what it was. My doctors feel that I

likely have had a form of Mito since I was a child as I was never able

to participate in gym for one reason or the other, nothing anyone could really

ever pin down. I pulled some info from

http//www.ncbi.nlm.nih.gov/enterz/query.fcgi? It's from the National Library of

Medicine and I have been trying to sort some of this out but I'm still in a fog.

It's raining in Kansas so I guess it's OK to be in a fog, especially when you

are 69. Thanks, Dolores

gillianstumps gill@...> wrote:not understanding genetics either

my Doc just wrote down for me the

following.... ?autosommal recesssive nuclear gene I loved his

question mark first my personal translation they don't know

LOL and mine is also adult onset...

Gillian

> > Dolores

> >

> > Just a note regarding your comment below, about great-

grandaughters. I'm

> > assuming you're referring to " maternal inheritance " . My

understanding of the

> > term is that, where it applies, it means that one can only

inherit something

> > from one's mother. In other words, I as a male cannot " give " it

to my

> > children, and furthermore my father could not have " given " it to

me. But

> > this term does NOT mean that only females can inherit the

disease. Males can

> > get it (from their mothers) but then cannot pass it on to their

children.

> >

> > So that means that your great-grandaughters AND your great-

grandsons could

> > get a maternally-inherited disease " from " you. However, it also

means that

> > this would only be the case if those great-grandchildren are

children of

> > your grand-DAUGHTER, who in turn is the child of your DAUGHTER.

> >

> > Hope I have that right. :-) Also, perhaps I've mis-assumed, and

you simply

> > made that reference because you don't have any great-grandsons.

In which

> > case, never mind. :-) It's also true (to my understanding) that

maternal

> > inheritance does not apply to all mito diseases.

> >

> > Anyway, my blessings for the best possible health for you, your

children,

> > your grandchildren, and your great-grandchildren, and so on

forever.

> >

> > Steve D.

> >

> > > Date: Tue, 31 May 2005 18:02:05 -0700 (PDT)

> > > From: Dolores

> > > Subject: Re: diagnosis

> > >

> > > [...] I just try to keep plugging away and pray that my

precious

> > Great-grandaughters will not have this problem handed down

> > > to them. Everytime I see the four month old roll her toes

under it

> > scares me to death as that was one of the things I used to do

for muscle

> > spasms a good lot of my life until they got so bad I would jump

out of bed

> > screaming. I know this really isn't giving answers but I hope

in some way

> > it will help. Dolores

> >

> >

> >

> > Medical advice, information, opinions, data and statements

contained herein are not necessarily those of the list moderators.

The author of this e mail is entirely responsible for its content.

List members are reminded of their responsibility to evaluate the

content of the postings and consult with their physicians regarding

changes in their own treatment.

> >

> > Personal attacks are not permitted on the list and anyone who

sends one is automatically moderated or removed depending on the

severity of the attack.

> >

> >

[Guest guest]

Similar to you, I have/had symptomatic but undiagnosed relatives on

both sides of the family, although that fact makes me think my mito

disorder may not be primary. My most symptomatic relative, very

similar to my case, stroke-like episodes and neuropathy among other

things, was my paternal uncle. But my mom also had visual

disturbances and weakness, and we have autotimmune disease on both

sides of the family as well.

Take care,

RH

> > > Dolores

> > >

> > > Just a note regarding your comment below, about great-

> grandaughters. I'm

> > > assuming you're referring to " maternal inheritance " . My

> understanding of the

> > > term is that, where it applies, it means that one can only

> inherit something

> > > from one's mother. In other words, I as a male cannot " give " it

> to my

> > > children, and furthermore my father could not have " given " it

to

> me. But

> > > this term does NOT mean that only females can inherit the

> disease. Males can

> > > get it (from their mothers) but then cannot pass it on to their

> children.

> > >

> > > So that means that your great-grandaughters AND your great-

> grandsons could

> > > get a maternally-inherited disease " from " you. However, it also

> means that

> > > this would only be the case if those great-grandchildren are

> children of

> > > your grand-DAUGHTER, who in turn is the child of your DAUGHTER.

> > >

> > > Hope I have that right. :-) Also, perhaps I've mis-assumed, and

> you simply

> > > made that reference because you don't have any great-grandsons.

> In which

> > > case, never mind. :-) It's also true (to my understanding) that

> maternal

> > > inheritance does not apply to all mito diseases.

> > >

> > > Anyway, my blessings for the best possible health for you, your

> children,

> > > your grandchildren, and your great-grandchildren, and so on

> forever.

> > >

> > > Steve D.

> > >

> > > > Date: Tue, 31 May 2005 18:02:05 -0700 (PDT)

> > > > From: Dolores

> > > > Subject: Re: diagnosis

> > > >

> > > > [...] I just try to keep plugging away and pray that my

> precious

> > > Great-grandaughters will not have this problem handed down

> > > > to them. Everytime I see the four month old roll her toes

> under it

> > > scares me to death as that was one of the things I used to do

> for muscle

> > > spasms a good lot of my life until they got so bad I would jump

> out of bed

> > > screaming. I know this really isn't giving answers but I hope

> in some way

> > > it will help. Dolores

> > >

> > >

> > >

> > > Medical advice, information, opinions, data and statements

> contained herein are not necessarily those of the list moderators.

> The author of this e mail is entirely responsible for its content.

> List members are reminded of their responsibility to evaluate the

> content of the postings and consult with their physicians regarding

> changes in their own treatment.

> > >

> > > Personal attacks are not permitted on the list and anyone who

> sends one is automatically moderated or removed depending on the

> severity of the attack.

> > >

> > >