Guest guest Posted March 11, 2005 Report Share Posted March 11, 2005 MSL is Multiple Symmetrical Lipomatosis, characterized by very large unencapsulated lipomas usually located on the back of the head and neck, shoulders, and upper back, usually in older males. It's very very rare (about 200 medically-known cases worldwide). Seems to either cause or be caused by lipid storage dysfunction (broken fatty acid metabolism). About half are known to be inherited, the other half probably spontaneous (long-term chemical exposure, including chronic alcoholism). Frequently but not always associated with mitochondrial mutation (about 15% have MERRF if I remember right). Many systemic neurological symptoms including typical mito stuff: extreme exercise intolerance, peripheral neuropathy, etc., due to (a) high triglycerides in blood, ( muscle inefficiency, © mass effect of the lipomas, and/or (d) downstream long-term results of any/all of these. Steve D. > Date: Thu, 10 Mar 2005 07:24:09 EST > From: MitomomX3@... > Subject: Re: Re: Cytochrome P450 deficiency in mitochondrial disease? > > steve, > what is MSL? > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 12, 2005 Report Share Posted March 12, 2005 Steve, thank you for the info, I have heard several people on the list mention lipomas. But never heard MSL. Have you also been tested for fatty acid defects then or MERRF? Quote Link to comment Share on other sites More sharing options...
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