mitoldies: biopsy question RC complexes

[Guest guest]

Hello..back with more questions..

I was wondering what it means if the resp chain complexes on the biopsy are

high...my daughter has 60% of complex II but I is slightly elevated ( 107% )

but 4 is 170% and II/III is 150% and 7 ( NADH cytochrome ) is 160%. complex

III and V arent tested on frozen..

I read somewhere that high complexes mean the mitochondria arent functioning

well...not sure if this is true...or is it that there is a blockage?

thanks

[Guest guest]

In some articles, one theory for elevated enzyme activity has been a

compensatory mechanism---the body's attempt to make up for other

deficiencies---but this was in relation to other metabolic cycles, not

mitochondrial respiratory chain enzymes. I have no idea if that would apply

here. In my case, the activity of non-mito enzymes tested has been above

normal whereas mito enzymes are deficient. One possible interpretation is

compensation.

B

_____

From: MitomomX3@...

Sent: Wednesday, February 23, 2005 8:40 AM

To:

Subject: : biopsy question RC complexes

Hello..back with more questions..

I was wondering what it means if the resp chain complexes on the biopsy are

high...my daughter has 60% of complex II but I is slightly elevated ( 107%

)

but 4 is 170% and II/III is 150% and 7 ( NADH cytochrome ) is 160%. complex

III and V arent tested on frozen..

I read somewhere that high complexes mean the mitochondria arent

functioning

well...not sure if this is true...or is it that there is a blockage?

thanks

[Guest guest]

In some articles, one theory for elevated enzyme activity has been a

compensatory mechanism---the body's attempt to make up for other

deficiencies---but this was in relation to other metabolic cycles, not

mitochondrial respiratory chain enzymes. I have no idea if that would apply

here. In my case, the activity of non-mito enzymes tested has been above

normal whereas mito enzymes are deficient. One possible interpretation is

compensation.

B

_____

From: MitomomX3@...

Sent: Wednesday, February 23, 2005 8:40 AM

To:

Subject: : biopsy question RC complexes

Hello..back with more questions..

I was wondering what it means if the resp chain complexes on the biopsy are

high...my daughter has 60% of complex II but I is slightly elevated ( 107%

)

but 4 is 170% and II/III is 150% and 7 ( NADH cytochrome ) is 160%. complex

III and V arent tested on frozen..

I read somewhere that high complexes mean the mitochondria arent

functioning

well...not sure if this is true...or is it that there is a blockage?

thanks

[Guest guest]

I'll have to look on my test results, I didn't think they did a count

of the number present, just the activity. Does % mean compared to a

normal amount of each complex, or does % mean % of normal activity?

For me, I recall noting that I had 0% activity for Complex I.

I agree that there could be compensation for the underacting complex,

by increase of others. But the doctor would probably give you a

better understanding of it.

Take care,

RH

> In some articles, one theory for elevated enzyme activity has been a

> compensatory mechanism---the body's attempt to make up for other

> deficiencies---but this was in relation to other metabolic cycles,

not

> mitochondrial respiratory chain enzymes. I have no idea if that

would apply

> here. In my case, the activity of non-mito enzymes tested has been

above

> normal whereas mito enzymes are deficient. One possible

interpretation is

> compensation.

>

>

>

> B

>

>

>

> _____

>

> From: MitomomX3@a... [mailto:MitomomX3@a...]

> Sent: Wednesday, February 23, 2005 8:40 AM

> To:

> Subject: : biopsy question RC complexes

>

>

>

> Hello..back with more questions..

> I was wondering what it means if the resp chain complexes on the

biopsy are

>

> high...my daughter has 60% of complex II but I is slightly

elevated ( 107%

> )

> but 4 is 170% and II/III is 150% and 7 ( NADH cytochrome ) is

160%. complex

>

> III and V arent tested on frozen..

> I read somewhere that high complexes mean the mitochondria arent

> functioning

> well...not sure if this is true...or is it that there is a

blockage?

> thanks

>

>

>

>

[Guest guest]

It would also depend on the lab and how they decide what is normal too.

ohgminion wrote:

>I'll have to look on my test results, I didn't think they did a count

>of the number present, just the activity. Does % mean compared to a

>normal amount of each complex, or does % mean % of normal activity?

>For me, I recall noting that I had 0% activity for Complex I.

>

>I agree that there could be compensation for the underacting complex,

>by increase of others. But the doctor would probably give you a

>better understanding of it.

>

>Take care,

>RH

>

>

>

>

>

>

>>In some articles, one theory for elevated enzyme activity has been a

>>compensatory mechanism---the body's attempt to make up for other

>>deficiencies---but this was in relation to other metabolic cycles,

>>

>>

>not

>

>

>>mitochondrial respiratory chain enzymes. I have no idea if that

>>

>>

>would apply

>

>

>>here. In my case, the activity of non-mito enzymes tested has been

>>

>>

>above

>

>

>>normal whereas mito enzymes are deficient. One possible

>>

>>

>interpretation is

>

>

>>compensation.

>>

>>

>>

>>B

>>

>>

>>

>> _____

>>

>>From: MitomomX3@a... [mailto:MitomomX3@a...]

>>Sent: Wednesday, February 23, 2005 8:40 AM

>>To:

>>Subject: : biopsy question RC complexes

>>

>>

>>

>>Hello..back with more questions..

>>I was wondering what it means if the resp chain complexes on the

>>

>>

>biopsy are

>

>

>>high...my daughter has 60% of complex II but I is slightly

>>

>>

>elevated ( 107%

>

>

>>)

>>but 4 is 170% and II/III is 150% and 7 ( NADH cytochrome ) is

>>

>>

>160%. complex

>

>

>>III and V arent tested on frozen..

>>I read somewhere that high complexes mean the mitochondria arent

>>functioning

>>well...not sure if this is true...or is it that there is a

>>

>>

>blockage?

>

>

>>thanks

>>

>>

>>

>>