Re: Cytochrome P450 deficiency in mitochondrial disease?

[Guest guest]

CYP450, also known as Cytochrome P450, is of great interest to me. This

enzyme FAMILY (in humans, found mostly in liver) is responsible for the

metabolic clearing of drugs, including the last stages of certain mito

activity. It is also responsible for regulating some steroid metabolism

(including the cholesterols) AND the metabolism of fatty acids. Very

interesting to me, since I have hepatic steatosis (fatty liver) AND (for

reasons I won't get into here) I suspect that valproic acid (Depakote) that

I consumed for many years may have triggered (somehow, downstream)

spontaneous mito mutations leading to my MSL ( which includes lipid storage

dysfunction).

There is a classification of the many isoforms and families of CYP450, and

much more info, at

http://www.anaesthetist.com/physiol/basics/metabol/cyp/cyp.htm

Steve D.

Date: Tue, 08 Mar 2005 19:10:21 -0000

Subject: Cytochrome P450 deficiency in mitochondrial disease?

My primary care doctor (a mainstream, allopathic physician) suggested

I may have a mitochondrial disorder. Meanwhile, a physician of

alternative medicine suggests that a major deficiency in my liver's

cytochrome P450 enzymes (AKA the phase I detoxification system) plays

a role in my symptoms.

Is deficiency in the CYP450 system seen in mitochondrial disorder? If

so, is there any thinking as to whether one of those issues might be

responsible for the development of the other (or if they might result

from a common cause)?

Thanks.

[Guest guest]

Info on Cytochrome P450's:

http://www.anaesthetist.com/physiol/basics/metabol/cyp/cyp.htm

This is a bit technical, but I think it's of interest to many of us.

Being a scientist and not a " lay person " , I know that even though

I've had a lot of training, getting all the terminology right for

even a close field (I'm a computational biochemist, but not a " real "

biochemist) is difficult.

Take care,

RH

> CYP450, also known as Cytochrome P450, is of great interest to me.

This

> enzyme FAMILY (in humans, found mostly in liver) is responsible for

the

> metabolic clearing of drugs, including the last stages of certain

mito

> activity. It is also responsible for regulating some steroid

metabolism

> (including the cholesterols) AND the metabolism of fatty acids. Very

> interesting to me, since I have hepatic steatosis (fatty liver) AND

(for

> reasons I won't get into here) I suspect that valproic acid

(Depakote) that

> I consumed for many years may have triggered (somehow, downstream)

> spontaneous mito mutations leading to my MSL ( which includes lipid

storage

> dysfunction).

>

> There is a classification of the many isoforms and families of

CYP450, and

> much more info, at

> http://www.anaesthetist.com/physiol/basics/metabol/cyp/cyp.htm

>

> Steve D.

>

> Date: Tue, 08 Mar 2005 19:10:21 -0000

> From: " rpanton24 "

> Subject: Cytochrome P450 deficiency in mitochondrial disease?

>

>

>

> My primary care doctor (a mainstream, allopathic physician)

suggested

> I may have a mitochondrial disorder. Meanwhile, a physician of

> alternative medicine suggests that a major deficiency in my liver's

> cytochrome P450 enzymes (AKA the phase I detoxification system)

plays

> a role in my symptoms.

>

> Is deficiency in the CYP450 system seen in mitochondrial disorder?

If

> so, is there any thinking as to whether one of those issues might be

> responsible for the development of the other (or if they might

result

> from a common cause)?

>

> Thanks.

[Guest guest]

Oops, duh, I think I sent the same link. But the advice is still

there, it is very technical...

Take care,

RH

> CYP450, also known as Cytochrome P450, is of great interest to me.

This

> enzyme FAMILY (in humans, found mostly in liver) is responsible for

the

> metabolic clearing of drugs, including the last stages of certain

mito

> activity. It is also responsible for regulating some steroid

metabolism

> (including the cholesterols) AND the metabolism of fatty acids. Very

> interesting to me, since I have hepatic steatosis (fatty liver) AND

(for

> reasons I won't get into here) I suspect that valproic acid

(Depakote) that

> I consumed for many years may have triggered (somehow, downstream)

> spontaneous mito mutations leading to my MSL ( which includes lipid

storage

> dysfunction).

>

> There is a classification of the many isoforms and families of

CYP450, and

> much more info, at

> http://www.anaesthetist.com/physiol/basics/metabol/cyp/cyp.htm

>

> Steve D.

>

> Date: Tue, 08 Mar 2005 19:10:21 -0000

> From: " rpanton24 "

> Subject: Cytochrome P450 deficiency in mitochondrial disease?

>

>

>

> My primary care doctor (a mainstream, allopathic physician)

suggested

> I may have a mitochondrial disorder. Meanwhile, a physician of

> alternative medicine suggests that a major deficiency in my liver's

> cytochrome P450 enzymes (AKA the phase I detoxification system)

plays

> a role in my symptoms.

>

> Is deficiency in the CYP450 system seen in mitochondrial disorder?

If

> so, is there any thinking as to whether one of those issues might be

> responsible for the development of the other (or if they might

result

> from a common cause)?

>

> Thanks.