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Another possible " good " side effect of taking larger folic acid doses.

Folic acid supplements also appear to lower blood pressure

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12/10/2004 - Folate, the B vitamin required by women to prevent birth

defects in their babies, also appears to reduce the risk of them

developing high blood pressure, shows new research.

Young women who consumed more than 800 micrograms of folate per day

reduced their risk of developing high blood pressure by almost a third

compared to those who consumed less than 200 ug/day, said researchers at

a special conference on high blood pressure in the US.

Most of those in the highest category of folate were boosting their

intake with folic acid supplements, demonstrating the additional value

of supplementing with the vitamin.

About two thirds of strokes and half the incidence of heart disease are

attributable to raised blood pressure, according to the World Health

Organisation. Worldwide, high blood pressure is estimated to cause 7.1

million deaths, about 13 per cent of the total and about 4.4 per cent of

the total chronic disease burden.

The researchers used data from more than 95,000 women collected during

the Nurses Health Study to compare quintiles of folate intake with blood

pressure in two age groups -- women from 26-46 years old, and 43-70

years old. None of the women had a history of high blood pressure when

the study started.

The most dramatic effects were seen among the younger group, where those

with the highest intake of folate, (more than 800 ug/day, including that

from supplements), showed a 29 per cent lower risk for high blood

pressure than those in the lowest quintile (consuming less than 200

ug/day of folate).

Older women who had total folate intake of 800 ug/day had a 13 per cent

lower risk.

Folate is found in citrus fruits, tomatoes, leafy green vegetables,

kidney beans and grain products. It has been shown to reduce levels of

homocysteine, a blood component that can damage blood vessels, and it

may also help blood vessels relax, improving blood flow, said P.

Forman, lead author of the study and a research and clinical fellow at

Brigham and Women's Hospital in Boston.

The benefit of folate was independent of other factors such as exercise,

salt intake and diet, which are known to influence risk of high blood

pressure.

Researchers also looked at the independent effect of supplemental folic

acid by analyzing the subset of women with very low dietary intake of

folate. The younger women who consumed 800 ug/day or more of folate

(comprised primarily of supplemental folic acid) had a 48 per cent

reduction in hypertension risk compared to those whose folate intake was

less than 200 ug/day (and who did not take supplements).

" It is very hard to get (800 micrograms folate daily) from diet alone, "

Forman told a Reuters Health report. " Essentially all the women in the

highest category took supplements. "

In the US, wheat flour has been fortified with folic acid since 1998 but

Europe has been reluctant to follow the example, despite increasing

evidence of the benefits not only to newborns but also the heart health

of adults.

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