Guest guest Posted March 1, 2005 Report Share Posted March 1, 2005 Dawn, As I understand it, in some cases progression can change the results of a biopsy. For example, ragged red fibers may not show up until later in the disease process. Atrophy or other signs of a myopathic process may also increase with time. However, the percentage of enzyme deficiency or the mutations in the DNA causing the deficiencies do not alter with progression. And those are the two primary ways of arriving at a specific diagnosis. I do think it's true that the more clinical signs a doctor sees, the more likely he/she will order aggressive testing. The same would be true for a muscle biopsy. The more abnormal signs seen in the initial tissue sample, the more likely they will order the specialized testing needed to diagnose mitochondrial disease. This is just my take based on experience with doctors and researchers. B _____ From: dawnanich Sent: Tuesday, March 01, 2005 9:00 AM To: Subject: Re: newbie * --- I was wondering if progression of the disease makes a difference in the biopsy results? Dawn A Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 1, 2005 Report Share Posted March 1, 2005 --- Thanks Barbara!! In , " Barbara Seaman " wrote: > Dawn, > > > > As I understand it, in some cases progression can change the results of a > biopsy. For example, ragged red fibers may not show up until later in the > disease process. Atrophy or other signs of a myopathic process may also > increase with time. However, the percentage of enzyme deficiency or the > mutations in the DNA causing the deficiencies do not alter with progression. > And those are the two primary ways of arriving at a specific diagnosis. I do > think it's true that the more clinical signs a doctor sees, the more likely > he/she will order aggressive testing. The same would be true for a muscle > biopsy. The more abnormal signs seen in the initial tissue sample, the more > likely they will order the specialized testing needed to diagnose > mitochondrial disease. This is just my take based on experience with > doctors and researchers. > > > > B > > > > _____ > > From: dawnanich [mailto:Danich1@w...] > Sent: Tuesday, March 01, 2005 9:00 AM > To: > Subject: Re: newbie > > > > * > --- I was wondering if progression of the disease makes a > difference in the biopsy results? > > Dawn A > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.