Re: what dose if replacing DMSA with DMPS?

[Guest guest]

>

> You personal observations coincide similarly with my previous post of

> approximate DMSA and DMPS absorption rates (20% and 50%). In your

> example, your body would be receiving about 30mgs per day of DMSA and

> 37.5 mgs of DMPS, roughly.

>

> Obviously there is a lot of individual variation in the way the body

> tolerates the different drugs and the fact that they have different

> half-lives, etc.

>

I checked to see if I could find sources for absorption rates of DMSA

and DMPS.

Oral absorption of DMSA was reported to be 20-22 % in: Aposhian HV,

Maiorino RM, Dart RC, DF. Urinary excretion of

meso-2,3-dimercaptosuccinic acid in human subjects. Clin Pharmacol

Ther. 1989 May;45(5):520-6

Oral absorption of DMPS was about reported to be about 39 % in:

Hurlbut KM, Maiorino RM, Mayersohn M, Dart RC, Bruce DC, Aposhian HV

Determination and metabolism of dithiol chelating agents. XVI:

Pharmacokinetics of 2,3-dimercapto-1-propanesulfonate after

intravenous administration to human volunteers. J Pharmacol Exp Ther.

1994 Feb;268(2):662-8.

I was surprised, I thought more of each was absorbed orally, but I was

wrong.

J