Does DMSA Cross Brain Barrier?

[Guest guest]

Ok, I know from the book that DMSA does not cross the blood brain

barrier. But I have enough doubt that I wanted to open up a friendly

discussion on the topic.

Andy says DMSA does not cross the barrier because the human barrier

is not as permeable as rats. DMSA does cross the barrier in rats. It

is assumed that since human barriers are not as permeable that DMSA

will not cross in humans. But I'm wondering, is anyone aware of hard

scientific evidence that DMSA does not cross the blood brain

barrier? For example, has an autopsy ever been done on someone who

was taking DMSA to see if it was in the brain?

I remember reading that mercury can disrupt, damage, or somehow

alter the brain barrier. Might it be possible that DMSA will not

normally cross the brain barrier, but that it could in someone who

is mercury damaged? Just food for thought.

I can only say that when I take DMSA it definitely feels like it

gets in the brain. I have no doubt about it, except that my favorite

author says it doesn't.

Depending on the website or source, there are claims DMSA does cross

the barrier and also claims that it doesn't. But the hard evidence

indicating why they believe what they do is missing. I haven't seen

convincing undisputable science either way. Does anyone know of any?

[Guest guest]

Here are a couple messages that talk about how and why ALA can cross the BBB,

not that I really understand this chemistry stuff, so maybe someone else can

make something of it. Andy says all lipophilic and amphiphilic things can cross

the BBB. So if I got this right, ALA can cross the blood brain barrier because

it is oily or fat soluble? And I believe DMSA and DMPS are only water soluble?

And that's why they don't get into cells and cross the BBB, and can only chelate

extracellular spaces? Do I have that right? Someone correct me if I'm

wrong!--------Jackie

http://health.groups.yahoo.com/group/Autism-Mercury/message/154053

http://health.groups.yahoo.com/group/Autism-Mercury/message/154018

In frequent-dose-chelation wrote:

Andy has said DMSA does not cross the blood brain barrier to a

clinically significant extent, which is different from saying

that not a single molecule of DMSA makes it across.

Go read the section on DMSA on Moria's website - more in A-M

archives, too. I didn't look very hard, but here are a couple:

http://health.groups.yahoo.com/group/Autism-Mercury/message/84471

http://health.groups.yahoo.com/group/Autism-Mercury/message/111049

--

>

> Ok, I know from the book that DMSA does not cross the blood brain

> barrier. But I have enough doubt that I wanted to open up a friendly

> discussion on the topic.

>

> Andy says DMSA does not cross the barrier because the human barrier

> is not as permeable as rats. DMSA does cross the barrier in rats. It

> is assumed that since human barriers are not as permeable that DMSA

> will not cross in humans. But I'm wondering, is anyone aware of hard

> scientific evidence that DMSA does not cross the blood brain

> barrier? For example, has an autopsy ever been done on someone who

> was taking DMSA to see if it was in the brain?

>

> I remember reading that mercury can disrupt, damage, or somehow

> alter the brain barrier. Might it be possible that DMSA will not

> normally cross the brain barrier, but that it could in someone who

> is mercury damaged? Just food for thought.

>

> I can only say that when I take DMSA it definitely feels like it

> gets in the brain. I have no doubt about it, except that my favorite

> author says it doesn't.

>

> Depending on the website or source, there are claims DMSA does cross

> the barrier and also claims that it doesn't. But the hard evidence

> indicating why they believe what they do is missing. I haven't seen

> convincing undisputable science either way. Does anyone know of any?

>

[Guest guest]

Here are a couple messages that talk about how and why ALA can cross the BBB,

not that I really understand this chemistry stuff, so maybe someone else can

make something of it. Andy says all lipophilic and amphiphilic things can cross

the BBB. So if I got this right, ALA can cross the blood brain barrier because

it is oily or fat soluble? And I believe DMSA and DMPS are only water soluble?

And that's why they don't get into cells and cross the BBB, and can only chelate

extracellular spaces? Do I have that right? Someone correct me if I'm

wrong!--------Jackie

http://health.groups.yahoo.com/group/Autism-Mercury/message/154053

http://health.groups.yahoo.com/group/Autism-Mercury/message/154018

In frequent-dose-chelation wrote:

Andy has said DMSA does not cross the blood brain barrier to a

clinically significant extent, which is different from saying

that not a single molecule of DMSA makes it across.

Go read the section on DMSA on Moria's website - more in A-M

archives, too. I didn't look very hard, but here are a couple:

http://health.groups.yahoo.com/group/Autism-Mercury/message/84471

http://health.groups.yahoo.com/group/Autism-Mercury/message/111049

--

>

> Ok, I know from the book that DMSA does not cross the blood brain

> barrier. But I have enough doubt that I wanted to open up a friendly

> discussion on the topic.

>

> Andy says DMSA does not cross the barrier because the human barrier

> is not as permeable as rats. DMSA does cross the barrier in rats. It

> is assumed that since human barriers are not as permeable that DMSA

> will not cross in humans. But I'm wondering, is anyone aware of hard

> scientific evidence that DMSA does not cross the blood brain

> barrier? For example, has an autopsy ever been done on someone who

> was taking DMSA to see if it was in the brain?

>

> I remember reading that mercury can disrupt, damage, or somehow

> alter the brain barrier. Might it be possible that DMSA will not

> normally cross the brain barrier, but that it could in someone who

> is mercury damaged? Just food for thought.

>

> I can only say that when I take DMSA it definitely feels like it

> gets in the brain. I have no doubt about it, except that my favorite

> author says it doesn't.

>

> Depending on the website or source, there are claims DMSA does cross

> the barrier and also claims that it doesn't. But the hard evidence

> indicating why they believe what they do is missing. I haven't seen

> convincing undisputable science either way. Does anyone know of any?

>

[Guest guest]

Recently I edited wikipedia articles on DMSA, DMPS and ALA giving

references in peer-reviewed journals stating that DMSA and DMPS don't

chelate mercury from the brain but that ALA does cross the BBB.

You can check the articles and the corresponding references at

http://en.wikipedia.org/wiki/Dimercaptosuccinic_acid

http://en.wikipedia.org/wiki/2%2C3-Dimercapto-1-propanesulfonic_acid

http://en.wikipedia.org/wiki/Lipoic_acid

Best regards,

>

> Ok, I know from the book that DMSA does not cross the blood brain

> barrier. But I have enough doubt that I wanted to open up a friendly

> discussion on the topic.

>

> Andy says DMSA does not cross the barrier because the human barrier

> is not as permeable as rats. DMSA does cross the barrier in rats. It

> is assumed that since human barriers are not as permeable that DMSA

> will not cross in humans. But I'm wondering, is anyone aware of hard

> scientific evidence that DMSA does not cross the blood brain

> barrier? For example, has an autopsy ever been done on someone who

> was taking DMSA to see if it was in the brain?

>

> I remember reading that mercury can disrupt, damage, or somehow

> alter the brain barrier. Might it be possible that DMSA will not

> normally cross the brain barrier, but that it could in someone who

> is mercury damaged? Just food for thought.

>

> I can only say that when I take DMSA it definitely feels like it

> gets in the brain. I have no doubt about it, except that my favorite

> author says it doesn't.

>

> Depending on the website or source, there are claims DMSA does cross

> the barrier and also claims that it doesn't. But the hard evidence

> indicating why they believe what they do is missing. I haven't seen

> convincing undisputable science either way. Does anyone know of any?

>

[Guest guest]

Interesting question. I hope Andy will weigh in here. I know that he has

looked at all kinds of obscure foreign-language studies on which he bases

many of his opinions. I'm told he has paid out of his own pocket to

translate many such studies, particularly Russian-language studies with

information not otherwise available. I wonder if these have been published

anywhere. If not, it would be great if Andy would compile all of these in

one place - a separate volume or his website perhaps - so we could all have

access to the original information.

However, I think it is overly simplistic and probably untrue to assume that

neurological symptoms are necessarily caused by mercury in the brain. We

know that autistic kids have very compromised guts, and their neurological

symptoms improve immensely when things are done to heal their guts. So it

is quite possible that brain fog, blurry vision and many other seemingly

neurological symptoms could improve when mercury is removed from the gut,

thyroid, adrenals, liver, kidneys, etc.

Dean

Re: Does DMSA Cross Brain Barrier?

Hi J,

I haven't seen any indisputable scientific evidence that says DMSA does or

does not cross the blood brain barrier. All I can say is that based on my

personal experience, doing five rounds of DMSA has diminished my brain fog

significantly and eradicated my blurry vision. I am doing colonics and far

infared saunas though, too, so I can't say it was the DMSA alone.

~ Carlin

stringworship jlafolle@...> wrote:

Ok, I know from the book that DMSA does not cross the blood brain

barrier. But I have enough doubt that I wanted to open up a friendly

discussion on the topic.

Andy says DMSA does not cross the barrier because the human barrier

is not as permeable as rats. DMSA does cross the barrier in rats. It

is assumed that since human barriers are not as permeable that DMSA

will not cross in humans. But I'm wondering, is anyone aware of hard

scientific evidence that DMSA does not cross the blood brain

barrier? For example, has an autopsy ever been done on someone who

was taking DMSA to see if it was in the brain?

I remember reading that mercury can disrupt, damage, or somehow

alter the brain barrier. Might it be possible that DMSA will not

normally cross the brain barrier, but that it could in someone who

is mercury damaged? Just food for thought.

I can only say that when I take DMSA it definitely feels like it

gets in the brain. I have no doubt about it, except that my favorite

author says it doesn't.

Depending on the website or source, there are claims DMSA does cross

the barrier and also claims that it doesn't. But the hard evidence

indicating why they believe what they do is missing. I haven't seen

convincing undisputable science either way. Does anyone know of any?

---------------------------------

Never miss a thing. Make Yahoo your homepage.

[Guest guest]

All I can add to this is that some of the brain is not protected by the

blood-brain barrier, particularly the hypothalmus which needs to be

exposed to the state of the body in order to regulate things.

I also have the experience that DMSA affects my brain. I can't explain

it, exactly, but it seems to. I also know that the claims that it does

are based on the rat study, so are invalid. How Andy came to the

conclusion that it doesn't, I don't know.

Dave.

Posted by: " stringworship " jlafolle@...

jlafolle@...?Subject=%20Re%3ADoes%20DMSA%20Cross%20Brain%20Barr\

ier%3F>

stringworship http://profiles.yahoo.com/stringworship>

Fri Mar 7, 2008 3:52 pm (PST)

Ok, I know from the book that DMSA does not cross the blood brain

barrier. But I have enough doubt that I wanted to open up a friendly

discussion on the topic.

Andy says DMSA does not cross the barrier because the human barrier

is not as permeable as rats. DMSA does cross the barrier in rats. It

is assumed that since human barriers are not as permeable that DMSA

will not cross in humans. But I'm wondering, is anyone aware of hard

scientific evidence that DMSA does not cross the blood brain

barrier? For example, has an autopsy ever been done on someone who

was taking DMSA to see if it was in the brain?

I remember reading that mercury can disrupt, damage, or somehow

alter the brain barrier. Might it be possible that DMSA will not

normally cross the brain barrier, but that it could in someone who

is mercury damaged? Just food for thought.

I can only say that when I take DMSA it definitely feels like it

gets in the brain. I have no doubt about it, except that my favorite

author says it doesn't.

Depending on the website or source, there are claims DMSA does cross

the barrier and also claims that it doesn't. But the hard evidence

indicating why they believe what they do is missing. I haven't seen

convincing undisputable science either way. Does anyone know of any?

[Guest guest]

All I can add to this is that some of the brain is not protected by the

blood-brain barrier, particularly the hypothalmus which needs to be

exposed to the state of the body in order to regulate things.

I also have the experience that DMSA affects my brain. I can't explain

it, exactly, but it seems to. I also know that the claims that it does

are based on the rat study, so are invalid. How Andy came to the

conclusion that it doesn't, I don't know.

Dave.

Posted by: " stringworship " jlafolle@...

jlafolle@...?Subject=%20Re%3ADoes%20DMSA%20Cross%20Brain%20Barr\

ier%3F>

stringworship http://profiles.yahoo.com/stringworship>

Fri Mar 7, 2008 3:52 pm (PST)

Ok, I know from the book that DMSA does not cross the blood brain

barrier. But I have enough doubt that I wanted to open up a friendly

discussion on the topic.

Andy says DMSA does not cross the barrier because the human barrier

is not as permeable as rats. DMSA does cross the barrier in rats. It

is assumed that since human barriers are not as permeable that DMSA

will not cross in humans. But I'm wondering, is anyone aware of hard

scientific evidence that DMSA does not cross the blood brain

barrier? For example, has an autopsy ever been done on someone who

was taking DMSA to see if it was in the brain?

I remember reading that mercury can disrupt, damage, or somehow

alter the brain barrier. Might it be possible that DMSA will not

normally cross the brain barrier, but that it could in someone who

is mercury damaged? Just food for thought.

I can only say that when I take DMSA it definitely feels like it

gets in the brain. I have no doubt about it, except that my favorite

author says it doesn't.

Depending on the website or source, there are claims DMSA does cross

the barrier and also claims that it doesn't. But the hard evidence

indicating why they believe what they do is missing. I haven't seen

convincing undisputable science either way. Does anyone know of any?

[Guest guest]

All I can add to this is that some of the brain is not protected by the

blood-brain barrier, particularly the hypothalmus which needs to be

exposed to the state of the body in order to regulate things.

I also have the experience that DMSA affects my brain. I can't explain

it, exactly, but it seems to. I also know that the claims that it does

are based on the rat study, so are invalid. How Andy came to the

conclusion that it doesn't, I don't know.

Dave.

Posted by: " stringworship " jlafolle@...

jlafolle@...?Subject=%20Re%3ADoes%20DMSA%20Cross%20Brain%20Barr\

ier%3F>

stringworship http://profiles.yahoo.com/stringworship>

Fri Mar 7, 2008 3:52 pm (PST)

Ok, I know from the book that DMSA does not cross the blood brain

barrier. But I have enough doubt that I wanted to open up a friendly

discussion on the topic.

Andy says DMSA does not cross the barrier because the human barrier

is not as permeable as rats. DMSA does cross the barrier in rats. It

is assumed that since human barriers are not as permeable that DMSA

will not cross in humans. But I'm wondering, is anyone aware of hard

scientific evidence that DMSA does not cross the blood brain

barrier? For example, has an autopsy ever been done on someone who

was taking DMSA to see if it was in the brain?

I remember reading that mercury can disrupt, damage, or somehow

alter the brain barrier. Might it be possible that DMSA will not

normally cross the brain barrier, but that it could in someone who

is mercury damaged? Just food for thought.

I can only say that when I take DMSA it definitely feels like it

gets in the brain. I have no doubt about it, except that my favorite

author says it doesn't.

Depending on the website or source, there are claims DMSA does cross

the barrier and also claims that it doesn't. But the hard evidence

indicating why they believe what they do is missing. I haven't seen

convincing undisputable science either way. Does anyone know of any?