confused about liver metabolism sulfation methylation section p. 110-111

[Guest guest]

On page 100, the paragraph that begins, " Phase 2 metabolism has many

parallel paths, " is particularly difficult for me to understand.

I'm assuming that, since he's talking about parallel paths, these

paths share similar " cures " . (?)

Here's the sentence (pathway) I have the biggest question about:

" Sulfation will show up most notably if the patient does well on the

Feingold diet, or if she responds poorly to DHEA supplementation. "

Could you also interpret the Feingold sentence this way:

" Liver Phase II enzyme reactions will be in evidence if the patient

improves by eliminating Salicylates, etc. "

I just have absolutely no idea what " show up " means in his sentence..

Or, er, I just plain don't get that whole sentence.

What I simply want to know is this: if I have poor sulfation (and

tons of chemical sensitivites as a result) do I want to eliminate

salicylate containing food or not?

Ok. Then the next sentence down the same paragraph says, " Impaired

methylation leads to slow clearance of epinephrine, norepinephrine

and dopamin, which would exacerbate agitation, anxiety

and " psychotic " symptoms. "

Since the topic was again brought up mid-paragraph, is Andy saying

that sulfation is in the same ballpark as methylation? I assume so..

So, overall here, it sounds like he's saying all these liver pathways

can be improved if the patient avoids salicylates, choline,

trimethylglycine, folic acid and vitamin B-12. Right?

Although I'm sure I have problems with slow phase II metabolism, I

just really hope I don't have to follow the Feingold diet and avoid

all those foods. I do great with sulphur foods if that helps?

And, btw, is choline the same as phoshatidyl choline, or close

enough? I get injections.

I've studied a lot of the book but need to get a bead on where I sit

with treatment. I'm almost psychotic reading pages 110 and 111 as

that piece seems core to my problems...

ANY help appreciated with that whole section on liver, sulfate,

suphur and sulfite metabolism..

Danke.

~robin

[Guest guest]

>

> On page 100, the paragraph that begins, " Phase 2 metabolism has many

> parallel paths, " is particularly difficult for me to understand.

>

> I'm assuming that, since he's talking about parallel paths, these

> paths share similar " cures " . (?)

Read also p. 40-43. This may help with understanding the liver

pathways.

> Here's the sentence (pathway) I have the biggest question about:

>

> " Sulfation will show up most notably if the patient does well on the

> Feingold diet, or if she responds poorly to DHEA supplementation. "

>

> Could you also interpret the Feingold sentence this way:

>

> " Liver Phase II enzyme reactions will be in evidence if the patient

> improves by eliminating Salicylates, etc. "

>

> I just have absolutely no idea what " show up " means in his sentence..

> Or, er, I just plain don't get that whole sentence.

I think it just means doing well on Feingold and responding poorly

to DHEA are indicators of sulfation problems.

> What I simply want to know is this: if I have poor sulfation (and

> tons of chemical sensitivites as a result) do I want to eliminate

> salicylate containing food or not?

Yes. Your sulfation pathway has to work to detoxify salicylates.

If you reduce your intake, you will reduce the burden on your body.

> Ok. Then the next sentence down the same paragraph says, " Impaired

> methylation leads to slow clearance of epinephrine, norepinephrine

> and dopamin, which would exacerbate agitation, anxiety

> and " psychotic " symptoms. "

>

> Since the topic was again brought up mid-paragraph, is Andy saying

> that sulfation is in the same ballpark as methylation? I assume so..

They are both phase 2 pathways, but you do different things to

support them.

> So, overall here, it sounds like he's saying all these liver pathways

> can be improved if the patient avoids salicylates, choline,

> trimethylglycine, folic acid and vitamin B-12. Right?

Avoiding salicylates reduces the burden on the sulfation pathway.

Taking molybdenum and sulfate may help your sulfation work better.

Taking choline, TMG, folic, and b12 helps the methylation pathway.

> Although I'm sure I have problems with slow phase II metabolism, I

> just really hope I don't have to follow the Feingold diet and avoid

> all those foods. I do great with sulphur foods if that helps?

You can do great with sulfur foods and still need Feingold diet.

> And, btw, is choline the same as phoshatidyl choline, or close

> enough? I get injections.

There are different forms. When Andy specifies phosphatidylcholine,

I would use that. I think for methylation, any choline might be okay,

but check the book.

> I've studied a lot of the book but need to get a bead on where I sit

> with treatment. I'm almost psychotic reading pages 110 and 111 as

> that piece seems core to my problems...

>

> ANY help appreciated with that whole section on liver, sulfate,

> suphur and sulfite metabolism..

There is recent discussion in archives about some of this. That

along with the p. 40-43 section might help.

--

> Danke.

>

> ~robin

>